Topical Metronidazole Does Not Abate UVB-Induced Erythema

Guarrera, Marcella; Brusati, C.; Rebora, Alfredo

doi:10.1159/000051725

Cited by 8 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared to placebo, metronidazole 0.75% gel was found to have a significant effect on erythema within the second 15 days of treatment, on D. folliculorum between the forty-fifth and sixtieth days of treatment, although Guarrera et al [30]reported that topical metronidazole 1% vanishing cream did not have any effect on UVB-induced erythema. We suggest that topical metronidazole may reduce erythema severity scores in rosacea since it is also possible that UVA-mediated mechanisms may well contribute to erythema in rosacea; metronidazole has photoprotective effects, especially with regard to UVA.…”

Section: Discussionmentioning

confidence: 99%

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

et al. 2002

View full text Add to dashboard Cite

Background: Permethrin 5% cream used against human ectoparasites suggests that it may be effective in papulopustular rosacea. Methods: This study included 63 patients diagnosed as having papulopustular rosacea based on the clinical and histological findings. Patients were randomly assigned into permethrin (n = 23), metronidazole (n = 20) and placebo (n = 20) groups. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and Demodex folliculorum were determined. Twenty-three patients were given permethrin 5% cream (Zalvor 5% skin cream^®), 20 patients metronidazole 0.75% gel (Roza gel^®) and 20 patients placebo cream (Basis cream^®), in packages looking identical to those of metronidazole and permethrin creams, and were recommended to apply them to their faces twice a day. All patients were also given SPF 20 cream for protection against sunlight. Two months of treatment were planned, and the patients were invited to the clinic for fortnightly controls. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and D. folliculorum were recorded at each visit. The mean scores of erythema and the mean numbers of papules, pustules and D. folliculorum were determined at baseline and on days 15, 30, 45 and 60. Side effects were also detected. Results: The effect of permethrin 5% cream on D. folliculorum was superior to that of metronidazole 0.75% gel. The effect of permethrin 5% cream on erythema and papules was found to be more effective than placebo and as effective as metronidazole 0.75% gel. However, it had no effect on telangiectasia, rhinophyma and pustules. Conclusion: It can be concluded that the application of permethrin 5% cream twice daily for 2 months can be as effective and reliable as metronidazole in the treatment of rosacea and a greater benefit can be gained when it is combined with other systemic and/or topical treatments.

show abstract

Section: Discussionmentioning

confidence: 99%

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Repetitive UVB irradiation of hairless mice has been used previously to evaluate test compounds on skin photoageing, photodamage, inflammation and tumor development . UVB–induced erythema also has been used clinically in healthy volunteers to assess the photoprotective and anti‐inflammatory activity of potential therapeutic agents . In the latter studies, UVB doses of approximately one to two times the minimal erythema dose were used, with erythema measured by chromameter.…”

Section: Discussionmentioning

confidence: 99%

“…[21][22][23][24] UVB-induced erythema also has been used clinically in healthy volunteers to assess the photoprotective and anti-inflammatory activity of potential therapeutic agents. [25,26] In the latter studies, UVB doses of approximately one to two times the minimal erythema dose were used, with erythema measured by chromameter. In the present study, we determined experimental conditions under which brief exposure to UVB induces skin erythema without causing skin ulcerations or other obvious skin damage.…”

Section: Discussionmentioning

confidence: 99%

Reduction in ultraviolet B light–induced erythema by oxymetazoline and brimonidine is mediated by different α‐adrenoceptors

Hsia

Tian

Gil

2018

Experimental Dermatology

View full text Add to dashboard Cite

When applied topically, oxymetazoline and brimonidine reduce the persistent facial erythema of rosacea; this effect is mediated by cutaneous vasoconstriction induced by postsynaptic activation of α-adrenoceptors. We investigated the α-adrenergic pharmacology of oxymetazoline and brimonidine. Functional activity on α-adrenoceptors was evaluated in vitro in HEK293 cells stably expressing single receptor subtypes using a fluorometric imaging plate reader Ca influx assay. Oxymetazoline was an α -adrenoceptor agonist with partial α -adrenoceptor activity, whereas brimonidine was a highly selective full α -adrenoceptor agonist. In vivo pharmacology was investigated in a mouse model of ultraviolet B light (UVB)-induced skin erythema. To selectively inhibit α-adrenoceptor subtypes, mice were injected with prazosin (an α -selective antagonist) or rauwolscine (an α -selective antagonist) following UVB exposure. Oxymetazoline cream 1.0%, brimonidine gel 0.33% or vehicle control was applied topically, and erythema was measured using a chromameter. Oxymetazoline and brimonidine reduced UVB-induced erythema compared with vehicle control (P < .01). The effect of oxymetazoline was impaired in prazosin-pretreated but not rauwolscine-pretreated mice. Conversely, the effect of brimonidine was impaired in rauwolscine-pretreated but not prazosin-pretreated mice. These data suggest that while oxymetazoline and brimonidine produce cutaneous vasoconstriction, they do so through different α-adrenergic mechanisms, with oxymetazoline primarily acting via α -adrenoceptors and brimonidine acting via α -adrenoceptors.

show abstract

“…In these cases, the terminology ‘acne rosacea’ seems appropriate. As far as therapeutic treatment is concerned, the anti-inflammatory activity is not the only way through which topical agents can reduce the clinical severity of rosacea [28]; eradication of ectoparasites has been reported to be effective in PPR rosacea [29]. …”

Section: Discussionmentioning

confidence: 99%

Rosacea: A Clinicopathological Approach

et al. 2004

View full text Add to dashboard Cite

Background: There are few reports of the histological changes in rosacea, and little attempt has been made to correlate such changes with clinical findings. In the present study, we describe in detail the histopathological features of rosacea in a large number of patients and simultaneously investigate the aetiopathogenesis of the disease based on the comparative assessment of epidemiological, clinical and histological findings. Methods: The study included 73 patients with rosacea. A skin biopsy with a 4-mm punch was performed in each case. All biopsy specimens included subcutaneous tissue. In 10 randomly selected patients, facial biopsy specimens were obtained from both involved and uninvolved (non-lesional) skin. Demodex mite presence was estimated semi-quantitatively under light microscopy. Patients with self-reported gastro-intestinal symptoms were submitted to upper gastro-intestinal endoscopy, and a rapid urease test was performed. Serological antibodies, IgG and IgA, against Helicobacter pylori were also detected. Results: The patients had a broad clinical spectrum of lesions. No specific histological features associated with either erythematous-telangiectatic or papulopustular clinical forms were noticed. Histological examination showed that there is no histological pattern unique to rosacea. Three different types of granulomas were observed: small palisaded ones around altered collagen and other granulomas of elastolytic and non-specific epithelioid type, all coexisting in 5 cases. The deep dermis and subcutis were frequently involved. Comparative study in 10 rosacea patients between lesional and non-lesional skin biopsies revealed almost the same histological changes to the latter biopsies, to a lesser degree though. Conclusion: Rosacea seems to be a reaction pattern to which a variety of pathogenetic routes may lead.

show abstract

Topical Metronidazole Does Not Abate UVB-Induced Erythema

Cited by 8 publications

References 14 publications

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

Reduction in ultraviolet B light–induced erythema by oxymetazoline and brimonidine is mediated by different α‐adrenoceptors

Rosacea: A Clinicopathological Approach

Contact Info

Product

Resources

About