Topical medicines for wound healing: A systematic review of Unani literature with recent advances

Fazil, Mohammad; Nikhat, Sadia

doi:10.1016/j.jep.2020.112878

Cited by 23 publications

(10 citation statements)

References 81 publications

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“…These results are consistent with findings in Zimbabwe, where 33% of women experienced harmful adverse events due to traditional medicine use during pregnancy [24]. While some research suggests that traditional medicine can support wound healing [40], the specific herbs and traditional medicines must be studied carefully in this context before encouraging its use. We must emphasize that most of the traditional medicine use reported was in pregnancy, and therefore the full mechanism linking traditional medicine use to SSIs, the possibility of underreporting use in the postpartum period, and SSI risk must be further explored.…”

Section: Discussionsupporting

confidence: 89%

Peripartum traditional medicine use and surgical site infections: A prospective cohort of women delivering via cesarean section in rural Rwanda

Bikorimana

Oryono

Miranda

et al. 2021

Preprint

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Background Traditional medicine is commonly used in low- and middle-income countries (LMICs). Little is known about the use of traditional medicine among women undergoing cesarean section (c-section) and the association to surgical site infections (SSIs) in LMICs. In this study, we describe peripartum use of traditional medicines and the risk of SSIs among women delivering via c-section in rural Rwanda.Methods This prospective cohort study enrolled women who underwent c-section at Kirehe District Hospital in rural Rwanda between September 2019 and February 2020. We collected self-reported data regarding traditional medicine use before and during pregnancy and after discharge up to postoperative day (POD) 11. On POD 11 (+/- 3 days), the women returned to the hospital for a study follow-up visit. We used Fisher’s exact test to assess the relationship between sociodemographic characteristics and traditional medicine use, and logistic regression to determine the association between traditional medicine use and SSI development while controlling for confounders. Results Of the 841 women enrolled in this study, 45 (5.4%) reported using traditional medicine to get pregnant. Nearly 39% used traditional medicine during pregnancy; the majority (96.9%) for a pregnancy-related reason. Only four women (0.5%) reported traditional medicine use between c-section and the POD 11 study visit. Of the 775 women who responded at all time-points, 341 (44.0%) reported using traditional medicine at some point during pregnancy or c-section recovery. No demographic characteristics were significantly associated with traditional medicine use (p>0.05), except for smoking (p=0.048) and alcohol consumption (p=0.010). Both traditional medicine use during pregnancy (p=0.04, aOR=2.0, 95% CI: 1.05, 3.85) and at any time point (p=0.04, aOR=2.0, 95% CI: 1.04, 3.83) were associated with development of SSI.Conclusions Traditional medicine use among c-section patients was high in the peripartum period, particularly during pregnancy, and was significantly associated with SSI. Knowing patterns of traditional medicine use during the peripartum period can help providers collaborate with traditional healers and give appropriate, culturally-sensitive pregnancy and postoperative care and counseling to patients.

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Section: Discussionsupporting

confidence: 89%

Peripartum traditional medicine use and surgical site infections: A prospective cohort of women delivering via cesarean section in rural Rwanda

Bikorimana

Oryono

Miranda

et al. 2021

Preprint

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“…The skin has the ability to repair itself following injuries due to surgery, trauma, or burns through cutaneous wound healing processes [ 116 ]. Generally, it involves four main stages, namely coagulation, inflammation, granulation, and remodeling, finally resulting in wound closure ( Figure 4 ) [ 116 , 117 ]. However, wound areas larger than 2 cm 2 , wound duration longer that 2 months, and increased wound depth which results in tendon, ligament, or bone exposure are the three main factors which delay or stop the healing process.…”

Section: Wound Dressings In Skin Cancermentioning

confidence: 99%

Regenerative Wound Dressings for Skin Cancer

Pavel

Chircov

Rădulescu

et al. 2020

Cancers

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Skin cancer is considered the most prevalent cancer type globally, with a continuously increasing prevalence and mortality growth rate. Additionally, the high risk of recurrence makes skin cancer treatment among the most expensive of all cancers, with average costs estimated to double within 5 years. Although tumor excision is the most effective approach among the available strategies, surgical interventions could be disfiguring, requiring additional skin grafts for covering the defects. In this context, post-surgery management should involve the application of wound dressings for promoting skin regeneration and preventing tumor recurrence and microbial infections, which still represents a considerable clinical challenge. Therefore, this paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described.

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“…The regeneration process can be interfered by the health status of the patient, nutrition, age, and place of injury, hampering the natural healing process (Choudhary et al, 2020;Moeini et al, 2020). Thus, herbal products from Caatinga species, have biomolecules able to simulate several biological pathways involved in the tissue regeneration process, promoting, for example, angiogenesis and collagen production (Fazil;Nikhat, 2020;Cavalcanti et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and wound healing properties from Caatinga plant species: how they do it? – A literature review

Miranda

Fernandes

Silva

et al. 2022

RSD

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Being one of the phytogeographic domains exclusively present in Brazil, the Caatinga occupies approximately 11% of the Brazilian territory and is one of the drylands with the most diversity around the world. The Caatinga is home to a floristic variety that carries a plurality of bioactive compounds capable of reversing physiological disorders. Many bioactive products from Caatinga species have anti-inflammatory and healing potential. The present review aimed to summarize the works that explored the anti-inflammatory and healing activities of plant species present in this phytogeographic domain. The articles were selected from the databases: Elsevier, Springer links, and PubMed to build the present review. In total, 39 plant species were identified, which were studied about their biological potential with experimental assays, and we’ve discussed how its compounds are related to the anti-inflammatory and healing activities. Our results highlight that the most studied product obtained from those plant species is the plant extract, and still those studies aren’t clear about its phytochemical profile. On the other hand, the research focused on plant oils provides a better understanding of how Caatinga plant species promote anti-inflammatory and wound healing action.

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Topical medicines for wound healing: A systematic review of Unani literature with recent advances

Cited by 23 publications

References 81 publications

Peripartum traditional medicine use and surgical site infections: A prospective cohort of women delivering via cesarean section in rural Rwanda

Peripartum traditional medicine use and surgical site infections: A prospective cohort of women delivering via cesarean section in rural Rwanda

Regenerative Wound Dressings for Skin Cancer

Anti-inflammatory and wound healing properties from Caatinga plant species: how they do it? – A literature review

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