Topical Lidocaine-ibuprofen versus Lidocaine-prilocaine as a Local Anesthetic Agent in Reducing Central Venous Catheter Insertion Pain: A Randomized Controlled Trial

Azizkhani, Reza; Najafabadi, Omid Ghayour; Heydari, Farhad; Saber, Mina; Mousavi, Sarah

doi:10.4274/eajem.galenos.2021.25633

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…In light of that, it should be noted that the current management strategies express moderate efficacy, leading to low quality of life and high costs of care [ 14 ]. While acetaminophen, nonsteroidal anti-inflammatory drugs, and opioids have traditionally been the go-to medications for pain management, there has been an urgent need for safer and more effective alternatives mostly due to the side effects that limit their use, including the high potential of addiction and tolerance [ 15 ]. In recent years, remedies such as some derivatives of mushrooms have emerged as promising sources of analgesics.…”

Section: Introductionmentioning

confidence: 99%

Muscimol as a treatment for nerve injury-related neuropathic pain: a systematic review and meta-analysis of preclinical studies

Ramawad,

Paridari,

Jabermoradi

et al. 2023

Korean J Pain

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Background Muscimol’s quick onset and GABAergic properties make it a promising candidate for the treatment of pain. This systematic review and meta-analysis of preclinical studies aimed at summarizing the evidence regarding the efficacy of muscimol administration in the amelioration of nerve injury-related neuropathic pain. Methods Two independent researchers performed the screening process in Medline, Embase, Scopus and Web of Science extracting data were extracted into a checklist designed according to the PRISMA guideline. A standardized mean difference (SMD [95% confidence interval]) was calculated for each. To assess the heterogeneity between studies, I 2 and chi-square tests were utilized. In the case of heterogeneity, meta-regression and subgroup analyses were performed to identify the potential source. Results Twenty-two articles met the inclusion criteria. Pooled data analysis showed that the administration of muscimol during the peak effect causes a significant reduction in mechanical allodynia (SMD = 1.78 [1.45–2.11]; P < 0.0001; I 2 = 72.70%), mechanical hyperalgesia (SMD = 1.62 [1.28–1.96]; P < 0.0001; I 2 = 40.66%), and thermal hyperalgesia (SMD = 2.59 [1.79–3.39]; P < 0.0001; I 2 = 80.33%). This significant amendment of pain was observed at a declining rate from 15 minutes to at least 180 minutes post-treatment in mechanical allodynia and mechanical hyperalgesia, and up to 30 minutes in thermal hyperalgesia ( P < 0 .0001). Conclusions Muscimol is effective in the amelioration of mechanical allodynia, mechanical hyperalgesia, and thermal hyperalgesia, exerting its analgesic effects 15 minutes after administration for up to at least 3 hours.

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Section: Introductionmentioning

confidence: 99%