Topical L-Ascorbic Acid

Pinnell, Sheldon R.; Yang, Hongqui; Omar, Mostafa M.; RIVIERE, NANCY MONTEIRO; DeBuys, Holly V.; Walker, Linda C.; WANG, YAOHUI; Levine, Mark

doi:10.1097/00042728-200102000-00008

Cited by 26 publications

(16 citation statements)

References 53 publications

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“…In addition, although ATIP showed in vitro protection of lipid membranes against free radicals, no in vivo effect was observed by the application of the formulation containing ATIP. As this substance is a lipid‐soluble vitamin C derivative similar to ascorbyl palmitate (24), and consequently has a low penetration into the skin, its efficacy could reduce when used under actual conditions of use, i.e. on human skin.…”

Section: Resultsmentioning

confidence: 99%

In vitro antioxidant activity and in vivo efficacy of topical formulations containing vitamin C and its derivatives studied by non‐invasive methods

Campos

Gonçalves

Gaspar

2008

Skin Research and Technology

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AA and its derivates presented an in vitro antioxidant activity but AA had the best antioxidant effect. In in vivo efficacy studies, only the formulation containing AA caused alterations in TEWL values and the formulation containing MAP caused alterations in the viscoelastic-to-elastic ratio. This way, vitamin C derivatives did not present the same effects of AA on human skin; however, MAP showed other significant effect-improving skin hydration, which is very important for the normal cutaneous metabolism and also to prevent skin alterations and early ageing.

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Section: Resultsmentioning

confidence: 99%

In vitro antioxidant activity and in vivo efficacy of topical formulations containing vitamin C and its derivatives studied by non‐invasive methods

Campos

Gonçalves

Gaspar

2008

Skin Research and Technology

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“…The optimal concentration of ascorbic acid depends on its formulation. For a product containing ascorbic acid to have the desired effect, it must have an ascorbic acid concentration greater than eight percent [26]. Studies have shown that a concentration greater than 20 percent does not increase its activity, but may cause some irritation [26].…”

Section: Topical Formulations Of Ascorbic Acidmentioning

confidence: 99%

Ascorbic Acid in Skin Health

et al. 2019

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Ascorbic acid (vitamin C) is a water-soluble vitamin and a recognized antioxidant drug that is used topically in dermatology to treat and prevent the changes associated with photoaging, as well as for the treatment of hyperpigmentation. Ascorbic acid has neutralizing properties of free radicals, being able to interact with superoxide, hydroxyl and free oxygen ions, preventing the inflammatory processes, carcinogens, and other processes that accelerate photoaging in the skin. Current research focuses on the search for stable compounds of ascorbic acid and new alternatives for administration in the dermis. Unlike plants and most animals, humans do not have the ability to synthesize our own ascorbic acid due to the deficiency of the enzyme L-gulono-gamma-lactone oxidase, which catalyzes the passage terminal in the ascorbic acid biosynthesis. To deal with this situation, humans obtain this vitamin from the diet and/or vitamin supplements, thus preventing the development of diseases and achieving general well-being. Ascorbic acid is involved in important metabolic functions and is vital for the growth and maintenance of healthy bones, teeth, gums, ligaments, and blood vessels. Ascorbic acid is a very unstable vitamin and is easily oxidized in aqueous solutions and cosmetic formulations. Ascorbic acid is extensively used as an ingredient in anti-aging cosmetic products, as sodium ascorbate or ascorbyl palmitate. This review discusses and describes the potential roles for ascorbic acid in skin health and their clinical applications (antioxidative, photoprotective, anti-aging, and anti-pigmentary effects) of topical ascorbic acid on the skin and main mechanisms of action. Considering the instability and difficulty in administering ascorbic acid, we also discuss the importance of several factors involved in the formulation and stabilization of their topical preparations in this review.

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“…Antioxidants have been incorporated into a number of antiaging products. The antioxidants ascorbic acid and α‐tocopherol are being extensively used and have been shown to provide protection against UV 37,42–44 . Other compounds, such as the glutathione‐related group of molecules that are normally present in skin, have been shown to provide protection when applied topically 45,46 .…”

Section: Discussionmentioning

confidence: 99%

The Polyhydroxy Acid Gluconolactone Protects Against Ultraviolet Radiation in an In Vitro Model of Cutaneous Photoaging

et al. 2004

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These results demonstrate the ability of the PHA gluconolactone to protect against UV radiation-induced elastin promoter activation. In addition, in vivo studies demonstrated that gluconolactone treatment does not result in a significant increase in sunburn cells. Further investigation of this and other PHAs is necessary to identify their potential role in preventing and repairing cutaneous photodamage.

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Topical L-Ascorbic Acid

Cited by 26 publications

References 53 publications

In vitro antioxidant activity and in vivo efficacy of topical formulations containing vitamin C and its derivatives studied by non‐invasive methods

In vitro antioxidant activity and in vivo efficacy of topical formulations containing vitamin C and its derivatives studied by non‐invasive methods

Ascorbic Acid in Skin Health

The Polyhydroxy Acid Gluconolactone Protects Against Ultraviolet Radiation in an In Vitro Model of Cutaneous Photoaging

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