Topical immunotherapy in the treatment of alopecia areata: the importance of the
            maintenance phase - report of two cases

Tonso, Thaís Martins; Romanelli, Caroline; Rezende, Ana Laura Rosifini Alves; Mendes, Cínthia; Oliveira, Ana Helena Kalies

doi:10.5935/scd1984-8773.2016831722

Cited by 2 publications

(5 citation statements)

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“…It does not pose a threat to life, but it causes psychological stress and impacts on the quality of life [2]. Its treatment is determined by the patient's age and the condition's degree of involvement [1].…”

Section: Discussionmentioning

confidence: 99%

“…Alopecia Areata (AA) is a systemic, autoimmune condition characterized by loss of hair, without any association with scarring or inflammatory processes. [1]. Its course is unpredictable, and the response to treatments is extremely variable.…”

Section: Introductionmentioning

confidence: 99%

“…The worldwide prevalence of AA ranges from 0.1% to 0.2%. Its etiology remains uncertain; it is known that influenced by genetics, autoimmune and environmental factors [1].…”

Section: Introductionmentioning

confidence: 99%

“…During the trichoscopy it is possible to find black dots, yellow dots and exclamation mark hairs. In the anatomopathological examination, in the acute phase, there is lymphocytic infiltrate (CD4+ T and CD8+T) peribulbar in anagen hairs, with a "swarm of bees" aspect [1]. The treatment for AA is aimed at suppressing the activity phase.…”

Section: Introductionmentioning

confidence: 99%

“…DPCP is a topical sensitizer that causes allergic contact dermatitis by acting as a hapten. Also DPCP is believed to have a variety of immunomodulatory effects [1].…”

Section: Introductionmentioning

confidence: 99%

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A reasonable Response to Diphensiprone in Pediatric Alopecia Patient: A Case Report

Dertlioğlu¹

2021

JCCRS

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Alopecia areata (AA) is an autoimmune disorder which accounts for the most frequent cause of inflammation based hair loss among dermatological outpatient attendances. It has an unpredictable course and its etiology has not yet been fully elucidated. Many alternatives treatments are available; however, none of them have been curative or preventive so far. Its treatment must be individualized, and aims at suppressing the phase of activity of the disease. Alopecia areata (AA) persistent for a minimum of 6 months and resistant to other treatments and/or severe AA are indications to use diphencyprone (DPCP). We report a 9 year-old boy with diffuse alopecia areata, who underwent topical immunotherapy with diphencyprone. The application procedures, the results obtained and the clinical follow-up are described. Treatment alternatives should be tried, especially in the pediatric age group, due to the prominent effects of the disease on the patient’s quality of life and consequent development of psychological impairments. In this case; DPCP application is a preferable treatment option in AA in the pediatric age group because is very easy, effective and with less side effects

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The worldwide prevalence of AA ranges from 0.1% to 0.2%. Its etiology remains uncertain; it is known that influenced by genetics, autoimmune and environmental factors [1].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…DPCP is a topical sensitizer that causes allergic contact dermatitis by acting as a hapten. Also DPCP is believed to have a variety of immunomodulatory effects [1].…”

Section: Introductionmentioning

confidence: 99%

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A reasonable Response to Diphensiprone in Pediatric Alopecia Patient: A Case Report

Dertlioğlu¹

2021

JCCRS

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Evaluation and Prognostication of Trichoscopic Findings in Patients With Alopecia Areata (Aa) Before and After Application of Diphenylcyclopropenone (Dpcp).

Poluri

Ahamed²,

Thiruveedhula

et al. 2023

ijsr

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Background: Alopecia areata (AA) is a chronic inammatory disease of hair follicles, causing non-scarring alopecia. Trichoscopy is a noninvasive and inexpensive diagnostic procedure used increasingly in dermatology and hence can be used to evaluate ndings in alopecia areata. Aims And Objectives: Ÿ To evaluate the clinical and trichoscopic ndings of patients with AA. Ÿ To identify prognostic factors in diphenylcyclopropenone (DPCP) response rate. Materials And Methods: Sixteen patients with AA were included, and baseline hair loss was calculated based on the severity of alopecia tool (SALT) score. Trichoscopic ndings of AA were evaluated at baseline before DPCP and at the end of 12 th week after DPCP application. Results: Men (M: F=4.3:1) with a mean age of 33.6 years were commonly affected with a mean duration of 9.9 months in this study. Most of the patients had localized type with three patches over the scalp and a SALT subclass of S1. The mean regrowth was 82.56 %. Trichoscopic ndings like black dots, depigmented vellus hairs, broken hairs, depigmented terminal hair, and exclamation mark hairs decreased whereas pigmented vellus hairs increased after the 12th week. Insufcient sample size Black dots, depigment Limitations: Conclusion: ed vellus hairs, broken hairs, and exclamatory mark hairs are considered to be bad prognostic factors and were found to be reduced with DPCP in our study whereas the signicant increase of pigmented vellus hairs which is a good prognostic factor was noted after DPCP when compared to baseline. This study concludes that trichoscopy is an invaluable tool in diagnosing AA and assessing the treatment response to DPCP.

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Topical immunotherapy in the treatment of alopecia areata: the importance of the maintenance phase - report of two cases

Cited by 2 publications

References 0 publications

A reasonable Response to Diphensiprone in Pediatric Alopecia Patient: A Case Report

A reasonable Response to Diphensiprone in Pediatric Alopecia Patient: A Case Report

Evaluation and Prognostication of Trichoscopic Findings in Patients With Alopecia Areata (Aa) Before and After Application of Diphenylcyclopropenone (Dpcp).

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