Topical Lactiplantibacillus plantarumLB244R® ointment alleviates skin aging: An exploratory trial

Abstract

Aging, the process of gradual decline whilst growing older, is potentially the most common all-encompassing reality, affecting everyone. One of the most visually prominent results of aging can be seen on the skin. The skin loses its firmness and elasticity, resulting in sagging, more apparent pores, and wrinkles. Additionally, the turnover number of cells in the skin decreases with the skin becoming less radiant, rougher in appearance, and drier as a result of reduced sebocyte activity, with an increasing number of pigment spots.

A proof of concept: Clinical anti‐aging efficacy and safety of Lactiplantibacillus plantarumLB244R® applied topically in a double‐blinded placebo‐controlled study

“…Skin biomechanical parameters were measured as previously, 15 using a Dual‐cutometer MPA 580® (Courage & Khazaka Electronic GmbH, Germany). Measurements were performed using a 2 mm probe, where negative pressure is created in the device (450 mBar) and after 2 s the skin is released.…”

“…Skin ultrasonography was measured as described previously. 15 Tissue density and dermis structures were assessed in the malar region, randomly assigned either left or right side, using a DermaScan C ultrasound system (Cortex technology, Denmark) with a modified 20 Mhz probe. Measurements were used to calculate the subepidermal low echogenic band (SLEB) thickness as well as skin density.…”

“…In our previous pilot study, we found that a topical ointment containing live Lactiplantibacillus plantarum LB244R® (previously identified for its inhibitory activity towards S. aureus CC-type 1 14 ) could alleviate all measured aging signs in a time span of 56 days. 15 The aim of this study was to build on our previous study and assess the anti-aging efficacy of the bacterial strain L. plantarum LB244R® for topical use as compared to its vehicle placebo, to specifically gain insight into the effect of the bacterium and use of topical LAB. This was done in a double-blinded, vehicle ointment placebo-controlled study with a total of 46 subjects enrolled.…”

Living, quiescent Lactobacillus plantarum Lp90 probiotic, delivered topically to full thickness tissues in vitro via a just‐add‐water cream delivery system, stimulates the expression of elastin protein

“…[7][8][9][10][11][12][13][14] Some companies, like Lactbio A/S, that have developed probiotic formulations using strictly anhydrous oil-based formulations. 15 These kinds of formulations are effective at maintaining the living, quiescent probiotics until they are placed onto the skin. Such formulations will feel oily and, of course, for the probiotics to become activated on the skin, they must find their way out of the oil matrix in which they are encapsulated and become activated by the limited moisture of the stratum corneum.…”

“…Some companies, like Lactbio A/S, that have developed probiotic formulations using strictly anhydrous oil‐based formulations 15 . These kinds of formulations are effective at maintaining the living, quiescent probiotics until they are placed onto the skin.…”