Topical hemostasis: a valuable adjunct to control bleeding in the operating room, with a special focus on thrombin and fibrin sealants

Doria, Cataldo; Vaccino, Silvia

doi:10.1517/14712590802689258

Cited by 14 publications

(9 citation statements)

References 17 publications

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“…Fibrin hydrogels have been extensively used in tissue engineering to support cell growth, and are biocompatible and biodegradable4, 5. Fibrin‐based tissue glues are routinely used in clinical medicine to promote tissue healing following surgery and trauma15–17 and have been used successfully employed for reducing lung volume in emphysema patients18, 19. Thus, fibrin‐based systems have an established safety profile in vivo .…”

Section: Discussionmentioning

confidence: 99%

Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung

Ingenito

Şen

Tsai

et al. 2009

J Tissue Eng Regen Med

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This study summarizes the development and testing of a scaffold to promote engraftment of cells in the distal lung. A fibrinogen-fibronectin-vitronectin hydrogel (FFVH) was developed and optimized with respect to its mechanical and biological properties for this application. In vitro, FFVH scaffolds promoted attachment, histiotypic growth and expression of basement membrane proteins by primary ovine lung mesenchymal cells derived from lung biopsies. In vivo testing was then performed to assess the ability of FFVHs to promote cell engraftment in the sheep lung. Treatment with autologous cells delivered using FFVH was clinically well tolerated. Cells labelled with a fluorescent dye (PKH-26) were detected at treatment sites after 1 month. Tissue mass (assessed by CT imaging) and lung perfusion (assessed by nuclear scintigraphy) were increased at emphysema test sites. Post-treatment histology demonstrated cell proliferation and increased elastin expression without scarring or collapse. No treatment-related pathology was observed at healthy control sites. FFVH scaffolds promote cell attachment, spreading and extracellular matrix expression in vitro and apparent engraftment in vivo, with evidence of trophic effects on the surrounding tissue. Scaffolds of this type may contribute to the development of cell-based therapies for patients with end-stage pulmonary diseases.

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Section: Discussionmentioning

confidence: 99%

Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung

Ingenito

Şen

Tsai

et al. 2009

J Tissue Eng Regen Med

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“…In addition, as a gelatin matrix absorbs blood, its volume expands several fold, contributing to haemostasis via tamponade. 25,26 In the present series, decannulation was achieved in 95% (19/20) of the Surgiflo patients and in 82.8% (29/35) in the control group.…”

Section: Discussionmentioning

confidence: 45%

“…1,24 Surgiflo ® consists of Surgifoam powder that is provided in a syringe, which is mixed either with saline or with human thrombin to create an injectable foam. 25 When used alone or with thrombin, gelatin provides a meshwork where the body's endogenous platelets, fibrin and thrombin may be entrapped, facilitating rapid clot formation. In addition, as a gelatin matrix absorbs blood, its volume expands several fold, contributing to haemostasis via tamponade.…”

Section: Discussionmentioning

confidence: 99%

Surgiflo^®may have a potential impact on the healing process in cricotracheal resection anastomosis

El-Fattah

Ebada

Tawfik

2020

Clinical Otolaryngology

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“…A direct approach to reducing intraoperative blood loss can be obtained through improved tissue hemostasis within the operative fi eld. Topically applied agents such as thrombin, 2 collagen, and fi brin glues 3 have been studied. These agents, which can be applied to the tissue surface prior to closure, can be effective in reducing postoperative blood loss, minimizing pain, and reducing the risk of exposure to allogeneic blood transfusion.…”

Section: Techniques To Manage Intraoperative Blood Loss Fibrin Sealantsmentioning

confidence: 99%

Limit the Bleeding, Limit the Pain in Total Hip and Knee Arthroplasty

Friedman¹

2010

Orthopedics

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Patients undergoing total hip or knee arthroplasty often sustain significant decreases in hemoglobin and hematocrit, despite modern techniques and shorter operating times. Reasons for the blood loss include raw bony surfaces, vascular inflammatory tissue, and fragile vessels in elderly patients. Acute postoperative anemia has numerous deleterious effects on patients, including delayed rehabilitation, exposure to allogeneic blood transfusions, higher complication rates, and increased pain. The ability to limit the amount of postoperative bleeding may reduce the amount of postoperative pain that patients experience, ultimately resulting in greater patient satisfaction and smoother postoperative rehabilitation. This article focuses on intraoperative techniques available to limit bleeding, thereby minimizing pain and the need for postoperative transfusion.

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Topical hemostasis: a valuable adjunct to control bleeding in the operating room, with a special focus on thrombin and fibrin sealants

Cited by 14 publications

References 17 publications

Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung

Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung

Surgiflo^®may have a potential impact on the healing process in cricotracheal resection anastomosis

Limit the Bleeding, Limit the Pain in Total Hip and Knee Arthroplasty

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Topical hemostasis: a valuable adjunct to control bleeding in the operating room, with a special focus on thrombin and fibrin sealants

Cited by 14 publications

References 17 publications

Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung

Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung

Surgiflo®may have a potential impact on the healing process in cricotracheal resection anastomosis

Limit the Bleeding, Limit the Pain in Total Hip and Knee Arthroplasty

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Product

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Surgiflo^®may have a potential impact on the healing process in cricotracheal resection anastomosis