Topical glycopyrrolate should not be overlooked in treatment of focal hyperhidrosis

Use of oral glycopyrronium bromide in hyperhidrosis

“…There are no studies comparing the efficacy and side‐effects of glycopyrrolate and propantheline. Glycopyrrolate tablets are not widely available 15 and are significantly more expensive than propantheline. Glycopyrrolate may be made up as an oral solution but it has a short shelf life.…”

Topical glycopyrrolate for patients with facial hyperhidrosis

“…Among these treatment choices, topical anticho-linergic agents, such as glycopyrrolate, have been reported to be effective in managing the facial sweating of craniofacial and gustatory hyperhidrosis. [3][4][5][6] Therefore, we investigated the efficacy, side-effect profile, and patients' preferences for topical glycopyrrolate in focal facial sweating.…”

Current and Emerging Medical Therapies for Primary Hyperhidrosis

“…An uncontrolled study of 35 patients with axillary hyperhidrosis who had failed aluminum chloride hexahydrate therapy was unable to show a consistent and meaningful benefit from glycopyrrolate compounded in Cetomacrogol Cream BP [30]. Glycopyrrolate may be used topically twice daily although some authors recommend applying it nightly [31]. Patients should be advised to avoid the nose, mouth, and eyes as the anticholinergic properties can prevent ocular accommodation [31].…”

“…Glycopyrrolate may be used topically twice daily although some authors recommend applying it nightly [31]. Patients should be advised to avoid the nose, mouth, and eyes as the anticholinergic properties can prevent ocular accommodation [31]. …”