Topical gel of Metformin solid lipid nanoparticles: A hopeful promise as a dermal delivery system

Rostamkalaei, Seyyed Sohrab; Âkbari, Jafar; Saeedi, Majid; Morteza‐Semnani, Katayoun; Nokhodchi, Ali

doi:10.1016/j.colsurfb.2018.11.072

Cited by 72 publications

(58 citation statements)

References 22 publications

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“…As the smaller particle size has a higher surface area, therefore, the drug molecules have more tendency to escape from the lipid matrix which resulted in lower EE% (8). The authors of this research article have also shown in other studies that an increase in the percentage of EE% could be attributed to the high solubility of naproxen in Span 80 (naproxen log p = 3.39 and water solubility is 0.0299 mg/ml) (14) or larger particle size in the case of metformin (log p = − 1.8 and water solubility is 1.38 mg/ml) (15). However, the increase in EE% due to an increase in the amount of Span and particle size was not the case for ATR-SLN8 where the amount of Span becomes more and the particle size becomes larger.…”

Section: Effect Of Hlb Of Surfactants On Nanoparticles Propertiessupporting

confidence: 64%

“…Generally, the zeta potential value is an indication of particle surface charge (the presence of lipid and surfactants) and the Stern layer (the presence of a free drug in the aqueous medium). When the zeta potential of metformin and naproxen solid lipid nanoparticles is compared with the zeta potential of the formulations obtained for atorvastatin, it can be concluded that nanoparticles are more negatively charged in the current study (− 7.7 ± 0.608 mV to − 17 ± 0.866 mV) than when metformin (− 0.651 ± 0.31 mV to − 6.180 ± 0.44 mV) (15) or naproxen (− 3.92 ± 0.71 mV to − 10.57 ± 0.57 mV) (14) was used. In the case of metformin, very low zeta potential could be due to the presence of a positively charged drug which makes zeta potential less negative.…”

Section: Effect Of Hlb Of Surfactants On Nanoparticles Propertiesmentioning

confidence: 66%

“…Many researchers have tried to apply atorvastatin for transdermal administration (12,13) and they have used lipid nanoparticles for avoiding the first-pass metabolism of atorvastatin (9). Although many publications have shown that the type and the amount of surfactant and lipid can have an influence on SLN properties, there are only two publications that studied the effect of HLB and the ratio of Span:Tween to optimize the properties of SLN in terms of size, polydispersity index, zeta potential, and entrapment efficiency percentage (14,15). The optimized formulation is selected for further studies (permeation studies).…”

Section: Introductionmentioning

confidence: 99%

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Atorvastatin Solid Lipid Nanoparticles as a Promising Approach for Dermal Delivery and an Anti-inflammatory Agent

et al. 2020

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In the current research, the main focus was to overcome dermal delivery problems of atorvastatin. To this end, atorvastatin solid lipid nanoparticles (ATR-SLNs) were prepared by ultra-sonication technique. The prepared SLNs had a PDI value of ≤ 0.5, and the particle size of nanoparticles was in the range 71.07 ± 1.72 to 202.07 ± 8.40 nm. It was noticed that, when the concentration of lipid in ATR-SLNs increased, the size of nanoparticles and drug entrapment efficiency were also increased. Results showed that a reduction in the HLB of surfactants used in the preparation of SLN caused an increase in the particle size, zeta potential (better stability), and drug entrapment efficiency. Despite Tween and Span are non-ionic surfactants, SLNs containing these surfactants showed a negative zeta potential, and the absolute zeta potential increased when the concentration of Span 80 was at maximum. DSC thermograms, FTIR spectra, and x-ray diffraction (PXRD) pattern showed good incorporation of ATR in the nanoparticles without any chemical interaction. In vitro skin permeation results showed that SLN containing atorvastatin was capable of enhancing the dermal delivery of atorvastatin where a higher concentration of atorvastatin can be detected in skin layers. This is a hopeful promise which could be developed for clinical studies of the dermal delivery of atorvastatin nanoparticles as an anti-inflammatory agent.

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Section: Effect Of Hlb Of Surfactants On Nanoparticles Propertiessupporting

confidence: 64%

Section: Effect Of Hlb Of Surfactants On Nanoparticles Propertiesmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

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Atorvastatin Solid Lipid Nanoparticles as a Promising Approach for Dermal Delivery and an Anti-inflammatory Agent

et al. 2020

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“…The surfactant system may be selected based on the particle size and polydispersity index (PI) of the resulting nanoparticles, as well as drug entrapment efficiency [9]. The hydrophile-lipophile balance (HLB) technique has been used to ensure the proper ratio of surfactants are used with the lipid selected [10,11].…”

Section: Introductionmentioning

confidence: 99%

Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles

et al. 2020

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Cryoprotectants are often required in lyophilization to reduce or eliminate agglomeration of solute or suspended materials. The aim of this study was to select a cryoprotecting agent and optimize its concentration in a solid lipid nanoparticle formulation. Progesterone-loaded stearic acid solid lipid nanoparticles (SA-P SLNs) were prepared by hot homogenization with high speed mixing and sonication. The stearic acid content was 4.6% w/w and progesterone was 0.46% w/w of the initial formulation. Multiple surfactants were evaluated, and a lecithin and sodium taurocholate system was chosen. Three concentrations of surfactant were then evaluated, and a concentration of 2% w/w was chosen based on particle size, polydispersity, and zeta potential. Agglomeration of SA-P SLNs after lyophilization was observed as measured by increased particle size. Dextran, glycine, mannitol, polyvinylpyrrolidone (PVP), sorbitol, and trehalose were evaluated as cryoprotectants by both an initial freeze–thaw analysis and after lyophilization. Once selected as the cryoprotectant, trehalose was evaluated at 5%, 10%, 15%, and 20% for optimal concentration, with 20% trehalose being finally selected as the level of choice. Evaluation by DSC confirmed intimate interaction between stearic acid and progesterone in the SA-P SLNs, and polarized light microscopy shows successful lyophilization of the trehalose/SA-P SLN. A short term 28-day stability study suggests the need for refrigeration of the final lyophilized SA-P SLNs in moisture vapor impermeable packaging.

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“…High power ultrasounds can break-down chemical bonds depolymerizing macromolecules, downsizing particles to nanoscale, making nanoemulsions, extracting bioactive substances from different matrices and so on, in research laboratories, in pharmaceutical and agrifood industries [40][41][42][43]. Sonochemistry was recently investigated for synthesis of bioactive nanostructures [44], different nanocarriers such as niosomes [45], liposomes [46], nanoemulsions [47], solid lipid nanoparticles [48], metal based systems [49], polymeric particles [50], nanoclusters [51] and nanocomposites [43]. Sonication processes were mainly performed to extract or degrade pesticides in order to support analysis and decontamination activities [52,53].…”

Section: Nanopesticides and Sonication Technologymentioning

confidence: 99%

Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa

Baldassarre

Tatulli²,

Vergaro

et al. 2020

Nanomaterials

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Recently, there is a growing demand in sustainable phytopathogens control research. Nanotechnology provides several tools such as new pesticides formulations, antibacterial nanomaterials and smart delivery systems. Metal nano-oxides and different biopolymers have been exploited in order to develop nanopesticides which can offer a targeted solution minimizing side effects on environment and human health. This work proposed a nanotechnological approach to obtain a new formulation of systemic fungicide fosetyl-Al employing ultrasonication assisted production of water dispersible nanocrystals. Moreover, chitosan was applicated as a coating agent aiming a synergistic antimicrobial effect between biopolymer and fungicide. Fosetyl-Al nanocrystals have been characterized by morphological and physical-chemical analysis. Nanotoxicological investigation was carried out on human keratinocytes cells through cells viability test and ultrastructural analysis. In vitro planktonic growth, biofilm production and agar dilution assays have been conducted on two Xylella fastidiosa subspecies. Fosetyl-Al nanocrystals resulted very stable over time and less toxic respect to conventional formulation. Finally, chitosan-based fosetyl-Al nanocrystals showed an interesting antibacterial activity against Xylella fastidiosa subsp. pauca and Xylella fastidiosa subsp. fastidiosa.

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Topical gel of Metformin solid lipid nanoparticles: A hopeful promise as a dermal delivery system

Abstract: Ali (2019) Topical gel of Metformin solid lipid nanoparticles: a hopeful promise as a dermal delivery system. Colloids and Surfaces B: Biointerfaces, 175. pp. 150-157.

Cited by 72 publications

References 22 publications

Atorvastatin Solid Lipid Nanoparticles as a Promising Approach for Dermal Delivery and an Anti-inflammatory Agent

Atorvastatin Solid Lipid Nanoparticles as a Promising Approach for Dermal Delivery and an Anti-inflammatory Agent

Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles

Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa

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