Topical Fundus Pulsation Measurement in Patients With Active Central Serous Chorioretinopathy

Tittl, Michael; Polska, Elżbieta; Kircher, Karl; Krüger, Andreas; Maár, Noémi; Stur, Michael; Schmetterer, Leopold

doi:10.1001/archopht.121.7.975

Cited by 46 publications

(25 citation statements)

References 28 publications

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“…The decreased choroidal blood flow might be correlated with the localized, nonperfused areas of the choriocapillaris frequently seen during ICG angiography (Kitaya et al, 2003). However, using a laser interferometry, the foveal fundus pulsation amplitude was significantly higher in CSCR eyes that in control eyes, suggesting choroidal hyperperfusion in CSCR patients (Tittl et al, 2003). The wavelength used in laser doppler flowmetry is shorter than in laser interferometry, which allows for the detection of red blood cells in the choriocapillaris rather than in the deeper large choroidal vessels.…”

Section: Choroidal Blood Flowmentioning

confidence: 98%

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Daruich

Matet

Dirani

et al. 2015

Progress in Retinal and Eye Research

795

996

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Central serous chorioretinopathy (CSCR) is a major cause of vision threat among middle-aged male individuals. Multimodal imaging led to the description of a wide range of CSCR manifestations, and highlighted the contribution of the choroid and pigment epithelium in CSCR pathogenesis. However, the exact molecular mechanisms of CSCR have remained uncertain. The aim of this review is to recapitulate the clinical understanding of CSCR, with an emphasis on the most recent findings on epidemiology, risk factors, clinical and imaging diagnosis, and treatments options. It also gives an overview of the novel mineralocorticoid pathway hypothesis, from animal data to clinical evidences of the biological efficacy of oral mineralocorticoid antagonists in acute and chronic CSCR patients. In rodents, activation of the mineralocorticoid pathway in ocular cells either by intravitreous injection of its specific ligand, aldosterone, or by over-expression of the receptor specifically in the vascular endothelium, induced ocular phenotypes carrying many features of acute CSCR. Molecular mechanisms include expression of the calcium-dependent potassium channel (KCa2.3) in the endothelium of choroidal vessels, inducing subsequent vasodilation. Inappropriate or over-activation of the mineralocorticoid receptor in ocular cells and other tissues (such as brain, vessels) could link CSCR with the known co-morbidities observed in CSCR patients, including hypertension, coronary disease and psychological stress.

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Section: Choroidal Blood Flowmentioning

confidence: 98%

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Daruich

Matet

Dirani

et al. 2015

Progress in Retinal and Eye Research

795

996

View full text Add to dashboard Cite

show abstract

“…In the past, changes in choroidal blood flow have already been reported in CSC patients based on laser Doppler flowmetry, laser interferometry, and laser speckle flowgraphy. Besides, areas of nonperfused CC seen during ICGA were described [55][56][57]. Interestingly, isometric exercise induced a more significant increase in choroidal blood flow in chronic CSC patients than in healthy patients, suggesting an inadequate vasoconstrictor response [58].…”

Section: Octa In Cscmentioning

confidence: 99%

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Lauermann¹,

Eter²,

Alten³

2018

Ophthalmologica

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The choriocapillaris (CC) represents a fundamentally important vascular layer that is subject to physiologic changes with increasing age and that is also associated with a wide range of chorioretinal diseases. So far, information on blood flow in this specific layer has remained limited. With the advent of optical coherence tomography angiography (OCTA), new perspectives and possibilities of CC imaging have begun to evolve. This article shall review the opportunities and challenges of applying OCTA technology to the CC layer and summarize the current clinical efforts in OCTA CC imaging exemplarily in dry age-related macular degeneration and central serous chorioretinopathy.

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“…While there is a robust limitation in evaluating choroidal circulation quantitatively with ICGA, other reliable techniques demonstrated quantitative data on choroidal circulation using laser interferometry10 and laser Doppler flowmetry 11. To the best of our knowledge, however, no data have been reported so far on the time course of quantitative changes in choroidal circulation in acute CSC, which would presumably lead to better understanding of the pathogenesis of CSC.…”

Section: Introductionmentioning

confidence: 99%

Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy

Saito

Hashimoto

et al. 2013

Br J Ophthalmol

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Topical Fundus Pulsation Measurement in Patients With Active Central Serous Chorioretinopathy

Cited by 46 publications

References 28 publications

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy

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