Topical foam as a promising carrier system for active pharmaceutical ingredients: review of clinical studies

Kotwiski, Fabiana O.; Albuquerque, Elaine C. de M. C.; Lucchese, Angélica M.

doi:10.1080/10837450.2023.2251556

Pharmaceutical Development and Technology

2023

DOI: 10.1080/10837450.2023.2251556

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Topical foam as a promising carrier system for active pharmaceutical ingredients: review of clinical studies

Fabiana O. Kotwiski,

Elaine C. de M. C. Albuquerque,

Angélica M. Lucchese

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2024

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Cited by 1 publication

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Liquid foam improves potency and safety of gene therapy vectors

Fitzgerald,

Stephan,

et al. 2024

Nat Commun

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Interest in gene therapy medicines is intensifying as the first wave of gene-correcting drugs is now reaching patient populations. However, efficacy and safety concerns, laborious manufacturing protocols, and the high cost of the therapeutics are still significant barriers in gene therapy. Here we describe liquid foam as a vehicle for gene delivery. We demonstrate that embedding gene therapy vectors (nonviral or viral) in a methylcellulose/xanthan gum-based foam formulation substantially boosts gene transfection efficiencies in situ, compared to liquid-based gene delivery. We further establish that our gene therapy foam is nontoxic and retained at the intended target tissue, thus minimizing both systemic exposure and targeting of irrelevant cell types. The foam can be applied locally or injected to fill body cavities so the vector is uniformly dispersed over a large surface area. Our technology may provide a safe, facile and broadly applicable option in a variety of clinical settings.

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Liquid foam improves potency and safety of gene therapy vectors

Fitzgerald,

Stephan,

et al. 2024

Nat Commun

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show abstract

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Topical foam as a promising carrier system for active pharmaceutical ingredients: review of clinical studies

Cited by 1 publication

References 79 publications

Liquid foam improves potency and safety of gene therapy vectors

Liquid foam improves potency and safety of gene therapy vectors

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