Topical Fluconazole Therapy of Candida Keratitis

Panda, Anita; Sharma, Namrata; Angra, Surender K

doi:10.1097/00003226-199607000-00007

Cited by 34 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fluconazole and ketoconazole show good intraocular penetration and are therefore good agents against keratitis with deep lesions [137]. They are the preferred treatment against both candida and filamentous fungi however, fluconazole has narrow coverage against filamentous organisms but ketoconazole is active against Aspergillus, Candida as well as Curvularia species [7,45,154].…”

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Pathogenesis of microbial keratitis

Lakhundi

Siddiqui

Khan

2017

Microbial Pathogenesis

173

121

View full text Add to dashboard Cite

Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye susceptible to corneal pathogens. Among bacterial pathogens, the most common agents responsible for keratitis include Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia and Serratia species. Fungal agents of corneal infections include both filamentous as well as yeast, including Fusarium, Aspergillus, Phaeohyphomycetes, Curvularia, Paecilomyces, Scedosporium and Candida species, while in protists, Acanthamoeba spp. are responsible for causing ocular disease. Clinical features include redness, pain, tearing, blur vision and inflammation but symptoms vary depending on the causative agent. The underlying molecular mechanisms associated with microbial pathogenesis include virulence factors as well as the host factors that aid in the progression of keratitis, resulting in damage to the ocular tissue. The treatment therefore should focus not only on the elimination of the culprit but also on the neutralization of virulence factors to minimize the damage, in addition to repairing the damaged tissue. A complete understanding of the pathogenesis of microbial keratitis will lead to the rational development of therapeutic interventions. This is a timely review of our current understanding of the advances made in this field in a comprehensible manner. Coupled with the recently available genome sequence information and high throughput genomics technology, and the availability of innovative approaches, this will stimulate interest in this field.

show abstract

Section: Treatmentmentioning

confidence: 99%

“…Corneal collagen cross-linking (CXL) is a relatively new technique currently been investigated in conjunction with photo-activated riboflavin (PAR) in refractory keratitis cases [102,137]. Investigations into the use of nanoparticle technology with terbinafine and silver have also shown promising results [189,214].…”

Section: Treatmentmentioning

confidence: 99%

Pathogenesis of microbial keratitis

Lakhundi

Siddiqui

Khan

2017

Microbial Pathogenesis

173

121

View full text Add to dashboard Cite

show abstract

“…It is shown to have a low side effect profile, good intraocular penetration, and a worthy agent to use in Candida keratitis with deep lesions. 46 Fluconazole has also been found efficacious in patients who do not respond to natamycin or miconazole in the treatment in the treatment of Candida keratitis. Topical 2 % fluconazole was found to be efficacious in six Indian patients with microscopy and culture-proven Candida keratitis with deep lesions.…”

Section: Fluconazolementioning

confidence: 99%

“…Three of these patients had not responded to topical natamycin, while the other three had not responded to topical miconazole. 46 Yet we must be cautious when we interpret this data, as natamycin is known to have poor coverage against Candida species.…”

Section: Fluconazolementioning

confidence: 99%

Current Thoughts in Fungal Keratitis: Diagnosis and Treatment

Ansari

Miller

Galor

2013

Curr Fungal Infect Rep

242

219

View full text Add to dashboard Cite

Fungal keratitis remains a challenging and often elusive diagnosis in geographic regions where it is endemic. Marred by delays in diagnosis, the sequelae of corneal fungal infections, though preventable, can be irreversible. Recent studies and advances in the arena have broadened the approach and treatment to mycotic keratitis. This review will discuss current diagnostic modalities of fungal keratitis and will particularly focus on treatment regimens. It will also explore future therapeutic models and critique the potential benefit of each.

show abstract

“…42,45 Econazole (1%) was recommended by some workers in the 1970s, 16,46 but there are no recent reports about the use of this compound as first-line therapy for mycotic keratitis. If yeasts or pseudohyphae are seen on microscopy, topical 0.15% amphotericin B, 10,44 fluconazole 2%, 47 natamycin 5%, 10 other azoles at 1% in arachis oil, or 1% flucytosine eye drops can be used. 13 Topical therapy is usually applied hourly around the clock for several days and the frequency of application is then gradually reduced; 42 'topical saturation therapy' has also been advocated.…”

mentioning

confidence: 99%