Topical Emulsion Containing Lavandula stoechas Essential Oil as a Therapeutic Agent for Cutaneous Wound Healing

Abstract

Background and objectives: The present research was designed to evaluate the chemical composition of Lavandula stoechas essential oil (EOLS) as well as the in vivo wound-healing property. The chemical composition of EOLS was identified by gas chromatography mass spectrometry. Nineteen compounds of EOLS were reported. Linalool was identified as the major chemical compound (24.87%), followed by linalyl acetate (19.10%). EOLS showed a high content of oxygenated compounds (63.54%). In vivo wound healing activity of the topical cream prepared from EOLS (0.5% w/w) was assessed using a circular excision wound model. The wound area (mm2) in all animal groups was estimated and measured on day 0, 4, 8, 11, and 16. Results: The EOLS formulation cream (0.5% v/w) showed the highest effect on wound models when compared to reference Madecassol® (Asiaticoside). On days 4, 11, and 16, wound contractions were 26.4%, 78%, and 96.3% for the EOLS-treated group, and 8.5%, 64.1%, and 86.1% for the vehicle cream-treated group. Animals treated with EOLS cream showed a significant decrease in the epithelization period, wound area, and scar thickness, whereas the rate of wound contraction significantly increased. This is the first such report to be published. Histological analyses were also consistent with the results of the excision experimental method. Treatment with EOLS cream formulation resulted in decreased inflammation and an increased rate of tissue perfusion and proliferation as well as remodeling, along with re-epithelization. Conclusions: Our results support the use of EOLS in the development of pharmaceuticals for the management of wounds, and/or inflammatory-related diseases. Additional studies are needed to elucidate and explain the exact mechanism of its pharmacological activity.

Essential Oil Plants Traditionally Used in Wound Treatment: Systematic Review

“…49 Lavandula stoechas L. was also studied for its wound healing effect. 50 The essential oil of Lavandula x allardii Hy, on the other hand, was investigated in combination with honey in a wound model, and it was revealed that its wound healing effect was quite high. 51 Lavender species and essential oils derived from different species of this genus are widely popular in studies involving wound models.…”

Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

“…On the other hand, and similarly to other aromatic plants of the Lamiaceae family, L. stoechas’ essential oils may present certain chemical variability. Even though the essential oils from several locations around the Mediterranean basin are mainly characterized by the presence of monoterpene ketones, such as fenchone and camphor, or by the oxygenated monoterpene 1,8-cineole, besides other volatiles such as linalool, linalyl acetate, terpineol, terpinen-4-ol, α-pinene, viridiflorol, camphene, among others [ 74 , 85 ].…”

“…The wound healing effects of L. stoechas using in vivo excision wound models have also been evaluated [ 8 , 74 ]. From this perspective, using Wistar albino rats, the methanolic extracts of L. stoechas and Mentha pulegium L. were incorporated in ointments at two distinct concentrations (5 and 10%) [ 8 ].…”

“…The authors concluded that the L. stoechas cream induced a significant decrease in the epithelization period, wound area and scar thickness, along with a significant increase in wound contraction. Moreover, this treatment also resulted in decreased inflammatory parameters and a great rate of tissue perfusion and proliferation, as well as remodeling and re-epithelization [ 74 ].…”

Valorizations of Marigold Waste for High-Value Products and Their Industrial Importance: A Comprehensive Review

“…Marigold has been unambiguously used to overcome the side effects of radiotherapy, but it may have significance for cancer treatment in the future [89]. Other known plants are Lavandula stoechas, Rhododendron arboreum, and Curcuma longa, which are used as therapeutic agents [90][91][92].…”