Topical emollient for preventing infection in preterm infants

Cleminson, Jemma; McGuire, William

doi:10.1002/14651858.cd001150.pub3

Cited by 37 publications

(21 citation statements)

References 66 publications

(19 reference statements)

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“…The most common perceived benefits of infant oil massage in the community include promotion of strength and health and maintenance of warmth ( 11 , 12 ). Further, there is recent evidence about benefits of using emollients in newborns especially preterm for improving weight gain, reducing the risk of infection and associated mortality ( 13 , 14 ).…”

Section: Resultsmentioning

confidence: 99%

Development and Implementation of Liposomal Encapsulated Micronutrient Fortified Body Oil Intervention for Infant Massage: An Innovative Concept to Prevent Micronutrient Deficiencies in Children

Apte

Lubree

Kapoor

et al. 2021

Front. Public Health

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Indian communities have the ancient cultural practice of gentle oil massage for infants which has been shown to play a beneficial role in neuro-motor development. The concept of incorporating nanosized liposomes of micronutrients (i.e., iron, folate, vitamin B12, and vitamin D) in the body oil leverages this practice for transdermal supplementation of essential micro-nutrients. This paper describes the experience of developing an intervention in the form of body oil containing nanosized liposomes of iron and micro-nutrients built on the social context of infant oil massage using a theory of change approach. The process of development of the intervention has been covered into stages such as design, decide and implement. The design phase describes how the idea of nanosized liposomal encapsulated micronutrient fortified (LMF) body oil was conceptualized and how its feasibility was assessed through initial formative work in the community. The decide phase describes steps involved while scaling up technology from laboratory to community level. The implementation phase describes processes while implementing the intervention of LMF oil in a community-based randomized controlled study. Overall, the theory of change approach helps to outline the various intermediate steps and challenges while translating novel technologies for transdermal nutrient fortification to community level. In our experience, adaptation in the technology for large scale up, formative work and pilot testing of innovation at community level were important processes that helped in shaping the innovation. Meticulous mapping of these processes and experiences can be a useful guide for translating similar innovations.

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Section: Resultsmentioning

confidence: 99%

Development and Implementation of Liposomal Encapsulated Micronutrient Fortified Body Oil Intervention for Infant Massage: An Innovative Concept to Prevent Micronutrient Deficiencies in Children

Apte

Lubree

Kapoor

et al. 2021

Front. Public Health

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“…Regarding approaches to health inequalities adopted by the interventions covered, the vast majority of reviews (forty-five in total) included interventions with a universal approach [ 48 , 50 , 55 , 58 – 63 , 66 – 68 , 71 – 74 , 77 – 81 , 85 – 88 , 90 – 102 , 104 – 108 , 110 ]. Twenty-six reviews included interventions adopting a targeted approach [ 48 , 49 , 54 , 56 , 57 , 62 – 65 , 67 , 68 , 70 , 72 , 75 , 76 , 78 , 82 – 85 , 89 , 92 , 97 , 99 , 103 , 109 ], and ten included a mix of both approaches [ 48 , 62 , 63 , 68 , 72 , 78 , 85 , 92 , 97 , 99 ]. None of the included reviews described interventions adopting a proportionate universalism approach.…”

Section: Resultsmentioning

confidence: 99%

“…Only twenty reviews reported intervention effects across different groups [ 48 , 50 , 58 , 63 , 68 , 69 , 72 , 77 , 80 , 81 , 83 , 88 , 93 , 94 , 97 , 99 , 102 , 104 , 109 , 110 ]. Another twenty one reviews reported the interventions’ effect on targeted disadvantaged groups as one population [ 49 , 54 , 56 , 57 , 61 – 64 , 67 , 75 , 76 , 82 – 85 , 88 , 89 , 92 , 97 , 99 , 103 ]. In terms of factors of disadvantages or variations in health covered by these studies, the most common ones found in the reviews are health-related vulnerabilities or higher needs (e.g.…”

Section: Resultsmentioning

confidence: 99%

“…Preventing infections in vulnerable neonates (2 reviews) . Two reviews, for which were assessed as high quality, synthesized the effect of targeted interventions in hospital settings to reduce the risk of infections in low-birth weight or premature neonates [ 56 , 57 ]. The higher health needs of low-birth weight or premature babies was the main factor of disadvantage covered in these reviews.…”

Section: Resultsmentioning

confidence: 99%

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Which public health interventions are effective in reducing morbidity, mortality and health inequalities from infectious diseases amongst children in low- and middle-income countries (LMICs): An umbrella review

et al. 2021

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Despite significant progress in the last few decades, infectious diseases remain a major threat to child health in low- and middle-income countries (LMICs)—particularly amongst more disadvantaged groups. It is imperative to understand the best available evidence concerning which public health interventions reduce morbidity, mortality and health inequalities in children aged under five years. To address this gap, we carried out an umbrella review (a systematic reviews of reviews) to identify evidence on the effects of public health interventions (promotion, protection, prevention) on morbidity, mortality and/or health inequalities due to infectious diseases amongst children in LMICs. Ten databases were searched for records published between 2014–2021 alongside a manual search of gray literature. Articles were quality-assessed using the Assessment of Multiple Systematic Reviews tool (AMSTAR 2). A narrative synthesis was conducted. We identified 60 systematic reviews synthesizing 453 individual primary studies. A majority of the reviews reported on preventive interventions (n = 48), with a minority on promotion (n = 17) and almost no reviews covering health protection interventions (n = 2). Effective interventions for improving child health across the whole population, as well as the most disadvantaged included communication, education and social mobilization for specific preventive services or tools, such as immunization or bed nets. For all other interventions, the effects were either unclear, unknown or detrimental, either at the overall population level or regarding health inequalities. We found few reviews reporting health inequalities information and the quality of the evidence base was generally low. Our umbrella review identified some prevention interventions that might be useful in reducing under five mortality from infectious diseases in LMICs, particularly amongst the most disadvantaged groups.

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“…Hans, et al, determined and described skin pH characteristics from 209 newborn infants [17]. However, after birth, the weakly alkaline skin becomes acidic in its quest to form the acid mantle [18,19] and the functional maturation of stratum corneum is accelerated within 2 to 8 weeks [20]. During this period, infant skin remains highly prone to damage.…”

Section: Ph Values On Skin Surfacesmentioning

confidence: 99%

Role of pH Value in Clinically Relevant Diagnosis

Kuo

Shen

et al. 2020

Diagnostics

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As a highly influential physiological factor, pH may be leveraged as a tool to diagnose physiological state. It may be especially suitable for diagnosing and assessing skin structure and wound status. Multiple innovative and elegant smart wound dressings combined with either pH sensors or drug control-released carriers have been extensively studied. Increasing our understanding of the role of pH value in clinically relevant diagnostics should assist clinicians and improve personal health management in the home. In this review, we summarized a number of articles and discussed the role of pH on the skin surface as well as the factors that influence skin pH and pH-relevant skin diseases, but also the relationship of skin pH to the wound healing process, including its influence on the activity of proteases, bacterial enterotoxin, and some antibacterial agents. A great number of papers discussing physiological pH value have been published in recent decades, far too many to be included in this review. Here, we have focused on the impact of pH on wounds and skin with an emphasis on clinically relevant diagnosis toward effective treatment. We have also summarized the differences in skin structure and wound care between adults and infants, noting that infants have fragile skin and poor skin barriers, which makes them more vulnerable to skin damage and compels particular care, especially for wounds.

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Topical emollient for preventing infection in preterm infants

Abstract: Analysis 1.4. Comparison 1 Topical ointment or cream versus routine skin care, Outcome 4 Invasive infection (other bacteria)..... Analysis 1.5. Comparison 1 Topical ointment or cream versus routine skin care, Outcome 5 Invasive infection

Cited by 37 publications

References 66 publications

Development and Implementation of Liposomal Encapsulated Micronutrient Fortified Body Oil Intervention for Infant Massage: An Innovative Concept to Prevent Micronutrient Deficiencies in Children

Development and Implementation of Liposomal Encapsulated Micronutrient Fortified Body Oil Intervention for Infant Massage: An Innovative Concept to Prevent Micronutrient Deficiencies in Children

Which public health interventions are effective in reducing morbidity, mortality and health inequalities from infectious diseases amongst children in low- and middle-income countries (LMICs): An umbrella review

Role of pH Value in Clinically Relevant Diagnosis

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