Topical emollient for preventing infection in preterm infants

Cleminson, Jemma; McGuire, William

doi:10.1002/14651858.cd001150.pub4

Cited by 16 publications

(17 citation statements)

References 78 publications

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“…Alternatively, natural oils have been in longstanding traditional use, but some oils may be harmful ( 104 , 105 ) while others have advantages with particular fatty acid profiles (e.g., higher linoleic acid content) ( 106 – 108 ). The use of sunflower oil as an emollient demonstrated a reduction in infections in neonates in a hospital-based study ( 109 ), and encouraging trends in a subgroup analysis of very low birth weight infants in a community-based study ( 106 ); however, more evidence is required ( 110 ). The strategy of combining emollients with antiseptics has also been the subject of recent pilot studies ( 47 ) and warrants further research.…”

Section: Maintenance Of Skin Integritymentioning

confidence: 99%

Healthcare-Associated Infection Prevention Interventions for Neonates in Resource-Limited Settings

Dramowski

Aucamp²,

Beales

et al. 2022

Front. Pediatr.

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Healthcare-associated infections (HAIs) and antimicrobial-resistant (AMR) infections are leading causes of neonatal morbidity and mortality, contributing to an extended hospital stay and increased healthcare costs. Although the burden and impact of HAI/AMR in resource-limited neonatal units are substantial, there are few HAI/AMR prevention studies in these settings. We reviewed the mechanism of action and evidence supporting HAI/AMR prevention interventions, including care bundles, for hospitalized neonates in low- and middle-income countries (LMIC).

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Section: Maintenance Of Skin Integritymentioning

confidence: 99%

Healthcare-Associated Infection Prevention Interventions for Neonates in Resource-Limited Settings

Dramowski

Aucamp²,

Beales

et al. 2022

Front. Pediatr.

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“…In this scenario, a preventive role of the policies of any single center regarding other prevention strategies can not be excluded. In neonates, fluconazole is generally well tolerated [ 28 , 29 , 30 ], but some concerns on the possible risk of neurodevelopmental impairment have been raised in the past [ 31 , 32 ]. Anyway, no negative effects in neonates under 750 g evaluated at 18 to 22 months of corrected age have been documented [ 20 ], and the evaluation at 8 to 10 years of life of neurodevelopmental status and quality of life of survivors from a randomized, placebo-controlled trial of fluconazole prophylaxis showed no differences in quality of life, behavior, communication, motor skills, and school performance [ 33 ].…”

Section: Pharmacological Prophylaxis With Antifungal Drugsmentioning

confidence: 99%

Prophylaxis of Invasive Fungal Infection in Neonates: A Narrative Review for Practical Purposes

Ferrando

Castagnola

2023

JoF

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Candida albicans is the most frequent cause of invasive fungal disease in preterm and/or low birth weight neonates, followed by Candida parapsilosis, whilst infections from other species are rare. Considering the severity of the disease, associated with poor clinical signs and diagnostic difficulties, primary prophylaxis becomes relevant. This paper summarizes the pathogenesis and clinical presentation of invasive candidiasis in neonates, focusing on prophylaxis. For late onset invasive disease, e.g., those occurring after the 3rd (or 7th according to some definitions) day of life possible approaches are the use of fluconazole, recommended in case of weight <1000 g or <1500 g if the local incidence of invasive candidiasis is higher than 2%, or the use of nystatin (for patients < 1500 g). Micafungin must be used in case of colonization by Candida auris, or in centers with a high prevalence of this pathogen. Concurrently, correct management of the central venous catheter and isolation procedures, with special regard to patients colonized by resistant strains, are fundamental. Other approaches such as reduced use of H2 blockers and broad-spectrum antibiotics (e.g., 3rd generation cephalosporins or carbapenems) and promotion of breast feeding proved useful. Reduction of early-onset infections (those occurring in the first 3 days of life) can also be obtained by treating maternal vulvo–vaginal candidiasis, which can represent a fastidious problem during pregnancy. In this case, topic azoles (the only recommendable treatment) can represent a kind of “prophylaxis” of early neonatal candidiasis. However, it must always be remembered that prophylaxis reduces the risk of invasive candidiasis but can not completely eliminate its occurrence, with the parallel risk of selecting for antifungal-resistant strains. Clinicians must maintain a high level of suspicion to start an appropriate therapy and strict epidemiological surveillance to identify the occurrence of clusters and the appearance of strains resistant to prophylaxis.

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“…Applications of some moisturisers, such as Aquaphor and Eucerin, have been shown to enhance skin barrier function, but not clinical outcomes in preterm neonates [ 13 ]. In contrast, several studies in cohorts of preterm infants in low-and middle-income countries have shown that sunflower seed oil (SSO) with high linoleic acid content (eg, >60%) provides benefits for the skin barrier and the survival, health, growth, and development of newborn infants [ 14 - 17 ].…”

Section: Use Of Emollients To Improve Skin Barrier Function and Healthmentioning

confidence: 99%

Optimised emollient mixture for skin barrier repair: Applications to global child health

Elias

Man

2022

J Glob Health

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Topical emollient for preventing infection in preterm infants

Abstract: Editorial group: Cochrane Neonatal Group. Publication status and date: New search for studies and content updated (conclusions changed), published in Issue 5, 2021.

Cited by 16 publications

References 78 publications

Healthcare-Associated Infection Prevention Interventions for Neonates in Resource-Limited Settings

Healthcare-Associated Infection Prevention Interventions for Neonates in Resource-Limited Settings

Prophylaxis of Invasive Fungal Infection in Neonates: A Narrative Review for Practical Purposes

Optimised emollient mixture for skin barrier repair: Applications to global child health

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