Topical Effectiveness of Filgrastim in Beta-Thalassaemia Leg Ulcer

Stavrianeas, N.; Xifteri, Areti; Kavatha, Dimitra; Vrettou, H.

doi:10.1159/000086456

Cited by 2 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are few reports of leg ulcers in association with thalassemia minor, usually because the underlying cause cannot be identified. Most reported cases occurred in women 1–3,5 of Italian descent with unilateral or bilateral malleolar ulcers; mean age at onset in these cases was 25.6 years; range, 14 to 44 years, and hemoglobin level was 6.3–10 g/dL.…”

Section: Discussionmentioning

confidence: 99%

“…They have rarely been reported in thalassemia minor (Table). 1–6 While both sexes are equally affected with thalassemia, there is a female predominance in cases with associated leg ulcers. We describe a case in which ulcus cruris developed in a woman with thalassemia, and we present an explanation for the difference in incidence between men and women.…”

Section: Published Cases Of Leg Ulcers In Thalassemia Minor Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Sex Differences in Bilateral Leg Ulcers in Thalassemia Minor

Goldberg

Atar²,

Brenner³

2007

Skinmed

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Published Cases Of Leg Ulcers In Thalassemia Minor Patientsmentioning

confidence: 99%

Sex Differences in Bilateral Leg Ulcers in Thalassemia Minor

Goldberg

Atar²,

Brenner³

2007

Skinmed

View full text Add to dashboard Cite

“…Granulocyte-macrophage colony-stimulating factor therapy has been associated with both partial [14] and complete [27] healing of leg ulcers. Other systemic therapies have included, pentoxifylline combined with deferoxamine in a relatively large study in which reduced healing time was associated with recurrence [23]; and pentoxifylline alone, associated with complete, albeit short-term, healing [22].…”

Section: Treatment Outcomesmentioning

confidence: 99%

Leg Ulcers: A Report in Patients with Hemoglobin E Beta Thalassemia and Review of the Literature in Severe Beta Thalassemia

et al. 2021

View full text Add to dashboard Cite

Background: Leg ulcers are a frequent complication in patients with the inherited hemoglobin disorders. In thalassemia, the literature is limited, and factors associated with the development of leg ulcers in HbE beta thalassemia, the most common form of severe beta thalassemia worldwide, have not previously been reported. Methods: We reviewed all available medical records of patients with HbE beta thalassemia to document the onset of leg ulcers at the two largest treatment centres in Sri Lanka. We reviewed the literature to identify studies reporting outcomes of interventions for ulcers in severe thalassemia. Results : Of a total of 255 actively registered patients with HbE thalassemia in the two centres, 196 patient charts were evaluable. A leg ulcer with a documented date of onset was recorded in 45 (22%) of 196 evaluable patients, aged (mean ± SEM) 22.2 ± 1.4 years. Most had been irregularly transfused; steady state hemoglobin was 6.4 ± 0.2 g/dL. Treatment achieving healing in 17 patients included transfusions, antibiotics, oral zinc, wound toileting and skin grafting. Discussion/Conclusion: Leg ulcers may be more common in HbE beta thalassemia than in other forms of thalassemia. A systematic approach to treatment will be needed to document the prevalence and factors placing such patients at risk for leg ulcers. Controlled trials to evaluate the optimal treatment of this common complication are indicated.

show abstract

Topical Effectiveness of Filgrastim in Beta-Thalassaemia Leg Ulcer

Cited by 2 publications

References 1 publication

Sex Differences in Bilateral Leg Ulcers in Thalassemia Minor

Sex Differences in Bilateral Leg Ulcers in Thalassemia Minor

Leg Ulcers: A Report in Patients with Hemoglobin E Beta Thalassemia and Review of the Literature in Severe Beta Thalassemia

Contact Info

Product

Resources

About