Topical Drug Delivery Using Liposomes and Liquid Crystalline Phases for Skin Cancer Therapy

Nogueira, Karina Alexandre Barros; Martins, Jéssica Roberta Pereira; Lima, Thayane; Alves, Jose Willams Bandeira; Aquino, Alanna Letícia do Carmo; Lima, Lorena Maria Ferreira de; Eloy, Josimar O.; Petrilli, Raquel

doi:10.1002/9781394167708.ch8

Cited by 1 publication

(1 citation statement)

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“…Table 1 delineates various prevalent drug nanocarriers, encompassing polymeric NPs, lipid NPs (such as liposomes, ethosomes, SLNs, and nanostructured lipid carriers), nanoemulsions, dendrimers, micelles, and inorganic NPs tailored for transdermal delivery. [18][19][20] Acne, psoriasis, ichthyosis [21][22][23] Anti-inflammatory [24,25] Nanostructured lipid carriers Yes No 50-500 Anti-inflammatory (Immuno-suppressive) [26] Local analgesic, anti-inflammatory [27,28] Antimicrobial [29] Anticancer [30] Nanoemulsions Yes No 10-1000 Cosmetic use: antioxidant, sunscreens, lipid carriers [31][32][33] Nonsteroidal anti-inflammatory drug carriers [34,35] Anticancer [36,37] Antimicrobial [38] Liposomes No Yes 100-200 Antimicrobial treatment [39,40] Eczema, psoriasis [41,42] Anti-inflammatory [43,44] Skin cancer [45,46] Local anesthesia [47,48] Ethosomes No Yes 100-200 Skin pathology [43,49] Skin cancer [50,51] Skin infections [52,53] Anti-inflammatory and analgesic [54,55] Micelles In the category of NPs, polymeric nanocapsules and nanospheres represent promising tools to increase the cutaneous permeation of pharmaceuticals and bioactive agents. Nanocapsules, characteri...…”

Section: Nanocarriers For Skin Applicationsmentioning

confidence: 99%

Characterization Methods for Nanoparticle–Skin Interactions: An Overview

Dzyhovskyi,

Romani,

Pula

et al. 2024

Life

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Research progresses have led to the development of different kinds of nanoplatforms to deliver drugs through different biological membranes. Particularly, nanocarriers represent a precious means to treat skin pathologies, due to their capability to solubilize lipophilic and hydrophilic drugs, to control their release, and to promote their permeation through the stratum corneum barrier. A crucial point in the development of nano-delivery systems relies on their characterization, as well as in the assessment of their interaction with tissues, in order to predict their fate under in vivo administration. The size of nanoparticles, their shape, and the type of matrix can influence their biodistribution inside the skin strata and their cellular uptake. In this respect, an overview of some characterization methods employed to investigate nanoparticles intended for topical administration is presented here, namely dynamic light scattering, zeta potential, scanning and transmission electron microscopy, X-ray diffraction, atomic force microscopy, Fourier transform infrared and Raman spectroscopy. In addition, the main fluorescence methods employed to detect the in vitro nanoparticles interaction with skin cell lines, such as fluorescence-activated cell sorting or confocal imaging, are described, considering different examples of applications. Finally, recent studies on the techniques employed to determine the nanoparticle presence in the skin by ex vivo and in vivo models are reported.

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