Topical Docosahexaenoic Acid (DHA) Accelerates Skin Wound Healing in Rats and Activates GPR120

Arantes, Eva L.; Dragano, Nathalia Romanelli Vicente; Ramalho, Antonio Sérgio; Vitorino, Daniele Cristina; Souza, Gabriela Freitas Pereira de; Lima, Maria; Velloso, Lı́cio A.; Araújo, Eliana P.

doi:10.1177/1099800415621617

Cited by 37 publications

(27 citation statements)

References 39 publications

(48 reference statements)

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“…The IL-10 level and collagen fiber organization were greater in the SMOFlipid group than the placebo after 48 h of treatment. The topical use of DHA (30 μM) hastened the skin wound healing through the inflammatory activity modulation in rats [102]. The wound in the DHA group was completely healed at day 15, whereas a 30% wound was still unhealed in the control.…”

Section: Fatty Acids For Skin Disorder Prevention and Treatmentmentioning

confidence: 99%

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

et al. 2018

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Fish oil has been broadly reported as a potential supplement to ameliorate the severity of some skin disorders such as photoaging, skin cancer, allergy, dermatitis, cutaneous wounds, and melanogenesis. There has been increasing interest in the relationship of fish oil with skin protection and homeostasis, especially with respect to the omega-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). The other PUFAs, such as α-linolenic acid (ALA) and linoleic acid (LA), also show a beneficial effect on the skin. The major mechanisms of PUFAs for attenuating cutaneous inflammation are the competition with the inflammatory arachidonic acid and the inhibition of proinflammatory eicosanoid production. On the other hand, PUFAs in fish oil can be the regulators that affect the synthesis and activity of cytokines for promoting wound healing. A systemic review was conducted to demonstrate the association between fish oil supplementation and the benefits to the skin. The following describes the different cosmetic and therapeutic approaches using fatty acids derived from fish oil, especially ALA, LA, DHA, and EPA. This review summarizes the cutaneous application of fish oil and the related fatty acids in the cell-based, animal-based, and clinical models. The research data relating to fish oil treatment of skin disorders suggest a way forward for generating advances in cosmetic and dermatological uses.

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Section: Fatty Acids For Skin Disorder Prevention and Treatmentmentioning

confidence: 99%

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

et al. 2018

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“…It remains to be determined, however, whether sPLA 2 -IIF-driven P-LPE would act on keratinocytes through a specific receptor or through other mechanism(s). It is also possible that DHA, another sPLA 2 -IIF-driven product, would be metabolized to certain metabolites that could affect skin homeostasis, since DHA or its pro-resolving metabolites can facilitate skin wound healing, suppress psoriasis, and prevent neoplastic transformation of keratinocytes [32][33][34]. sPLA 2 -IIE, a hair follicular sPLA 2…”

Section: Introductionmentioning

confidence: 99%

Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics

2018

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The skin represents one of the tissues that are most profoundly influenced by alterations in the quality of lipids (lipoquality). Lipids not only constitute cellular membranes, but also serve as bioactive lipid mediators and essential components of the skin barrier. Phospholipase A2 (PLA2) enzymes supply fatty acids and lysophospholipids from membrane phospholipids, thereby variably affecting cutaneous homeostasis. Accordingly, perturbation of particular PLA2-driven lipid pathways can be linked to various forms of skin disease. In this review article, we highlight the roles of several PLA2 subtypes in cutaneous pathophysiology, as revealed by transgenic/knockout studies in combination with comprehensive lipidomics. We focus mainly on secreted PLA2 group IIF (sPLA2-IIF), which is associated with epidermal hyperplasia through mobilization of a unique lipid metabolite. We also address the distinct roles of sPLA2-IIE in hair follicles and sPLA2-IID in lymphoid immune cells that secondarily affect cutaneous inflammation, and provide some insights into species differences in sPLA2s. Additionally, we briefly overview the patatin-like phospholipase PNPLA1, which belongs to the Ca2+-independent PLA2 (iPLA2) family, as a key regulator of skin barrier function through catalysis of a unique non-PLA2 reaction. These knowledges on lipid metabolism driven by various PLA2 subtypes will open novel opportunities for translated studies toward diagnosis and therapy of human skin diseases.

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“…Metadichol is an agonist of GPR 120 [34]. This is another pathway though which it can act as shown by Arantes El et al [35] that the topical use of GPR 120 agonists like polyunsaturated fatty acids (PUFAs) can accelerate skin wound healing. Da Younz et al [36] have shown that GPR120 agonist treatment of high-fat diet-fed obese mice causes improved glucose tolerance, decreased hyperinsulinemia, increased insulin sensitivity and decreased hepatic steatosis.…”

Section: Resultsmentioning

confidence: 99%

Metadichol® and Healthy Skin: One Approach many Possible Cures

Raghavan¹

2018

J Clin Exp Dermatol Res

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Metadichol ® a nano formulation of long-chain lipid alcohols derived from food. It is an inverse agonist of Vitamin D Receptor (VDR), Aryl Hydrocarbon Receptor (AHR), and Ror Game (RORC) that could have beneficial effects on skin diseases. We now present case studies of patents with various skin disease show Metadichol is an inverse agonist of these nuclear receptors thus modulating Th1 pathway towards a TH2 and Th 17 and IL 17 and IL22 and also being a TNF alpha inhibitor can modulate IL23 thus blocking the major pathways that exacerbate many Skin diseases. Metadichol is the first molecule successfully navigates around the problems involved with promiscuous ligands and targets. It fulfils the goals of the emerging field of Poly pharmacology, i.e. a single drug is able to bind to multiple targets beyond the "one drug, one target" philosophy. We show how Metadichol is an innovative treatment for treating multiple skin diseases eczema, acne, diabetic wounds and viral and bacterial infection and also improving skin texture. Metadichol ® is a safe nontoxic low cost solution and is an alternative to numerous clinical candidates in combating over 3000 skin diseases. Figure 1: Representation of International Classification of Diseases, Ninth Revision (ICD-9) diagnosis codes.

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Topical Docosahexaenoic Acid (DHA) Accelerates Skin Wound Healing in Rats and Activates GPR120

Abstract: Topical DHA improved skin wound healing. The activation of GPR120 is potentially involved in this process.

Cited by 37 publications

References 39 publications

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics

Metadichol® and Healthy Skin: One Approach many Possible Cures

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