“…The 3, 6 and12 months-PFS was similar in both arms, however, patients in the experimental dose, had a significantly milder toxicity profile. D-TORCH was a study assessing the role of 1% topical diclofenac preventing capecitabine associated hand-foot-syndrome [ 33 , 34 ]. A total of 20 patients developed hand-foot syndrome, 6 (7.8%) in the diclofenac arm and 14 (19.7%) in the placebo arm (p = 0.034).…”