Topical delivery of antifungal Brazilian red propolis benzophenones-rich extract by means of cationic lipid nanoemulsions optimized by means of Box-Behnken Design

Fasolo, Daniel; Pippi, Bruna; Meirelles, Gabriela de Carvalho; Zorzi, Giovanni K.; Fuentefria, Alexandre M.; Poser, Gilsane von; Teixeira, Hélder Ferreira

doi:10.1016/j.jddst.2020.101573

Cited by 14 publications

(8 citation statements)

References 42 publications

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“…Based on the good sensorial properties and biophysical properties, nanoemulsion has been determined as a good delivery system in topical applications. There are various reported methods which support the administration of a nanoemulsion formulation through topical applications [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

An Improved Nanoemulsion Formulation Containing Kojic Monooleate: Optimization, Characterization and In Vitro Studies

et al. 2020

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Tyrosinase inhibitors have become increasingly important targets for hyperpigmentation disease treatment. Kojic monooleate (KMO), synthesized from the esterification of kojic acid and oleic acid, has shown a better depigmenting effect than kojic acid. In this study, the process parameters include the speed of high shear, the time of high shear and the speed of the stirrer in the production of nanoemulsion containing KMO was optimized using Response Surface Methodology (RSM), as well as evaluated in terms of its physicochemical properties, safety and efficacy. The optimized condition for the formulation of KMO nanoemulsion was 8.04 min (time of high shear), 4905.42 rpm (speed of high shear), and 271.77 rpm (speed of stirrer), which resulted in a droplet size of 103.97 nm. An analysis of variance (ANOVA) showed that the fitness of the quadratic polynomial fit the experimental data with large F-values (148.79) and small p-values (p < 0.0001) and an insignificant lack of fit. The optimized nanoemulsion containing KMO with a pH value of 5.75, showed a high conductivity value (3.98 mS/cm), which indicated that the nanoemulsion containing KMO was identified as an oil-in-water type of nanoemulsion. The nanoemulsion remains stable (no phase separation) under a centrifugation test and displays accelerated stability during storage at 4, 25 and 45 °C over 90 days. The cytotoxicity assay showed that the optimized nanoemulsion was less toxic, with a 50% inhibition of cell viability (IC50) > 500 μg/mL, and that it can inhibit 67.12% of tyrosinase activity. This study reveals that KMO is a promising candidate for the development of a safe cosmetic agent to prevent hyperpigmentation.

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Section: Introductionmentioning

confidence: 99%

An Improved Nanoemulsion Formulation Containing Kojic Monooleate: Optimization, Characterization and In Vitro Studies

et al. 2020

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“…Furthermore, the insignicant lack of t value (p if > 0.05) highlights the adequacy of all response surfaces. [18][19][20] 3.1.2 Effect of independent variables on particle size and encapsulation efficiency. The effect of each independent variable on particle size is described by eqn (6) and shown in the corresponding 3D response surface plots (Fig.…”

Section: Resultsmentioning

confidence: 99%

Preparing, optimising, and evaluating chitosan nanocapsules to improve the stability of anthocyanins from Aronia melanocarpa

Wang

Wan

et al. 2021

RSC Adv.

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“…Then, they were kept under constant magnetic stirring for 48 h at 25 ± 1 °C. The samples were centrifuged (Hettich MIKRO 220R, Hettich, DEU) at 18840 g for 30 min (15 °C) to remove excess undissolved extract and the supernatant was recovered ( Fasolo et al, 2020 ). The supernatant was filtered (0.45 µm) and adequately diluted with methanol for the determination of the extract content at 210 nm using a spectrophotometer (Cary 50 Bio UV–Visible, Varian, Mulgrave, AUS).…”

Section: Materials Y Methodsmentioning

confidence: 99%

Use of jackfruit leaf (Artocarpus heterophyllus L.) protein hydrolysates as a stabilizer of the nanoemulsions loaded with extract-rich in pentacyclic triterpenes obtained from Coccoloba uvifera L. leaf

et al. 2021

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Highlights Jackfruit leaf protein hydrolysates have emulsifying properties. Nanoemulsions stabilized with jackfruit leaf protein hydrolysates were developed. Leaf protein hydrolysate is a promising encapsulant of triterpenic extract. Nanoemulsion stabilized with leaf protein hydrolysates were relatively stable. Jackfruit leaf hydrolysates could be an alternative to conventional emulsifier.

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Topical delivery of antifungal Brazilian red propolis benzophenones-rich extract by means of cationic lipid nanoemulsions optimized by means of Box-Behnken Design

Cited by 14 publications

References 42 publications

An Improved Nanoemulsion Formulation Containing Kojic Monooleate: Optimization, Characterization and In Vitro Studies

An Improved Nanoemulsion Formulation Containing Kojic Monooleate: Optimization, Characterization and In Vitro Studies

Preparing, optimising, and evaluating chitosan nanocapsules to improve the stability of anthocyanins from Aronia melanocarpa

Use of jackfruit leaf (Artocarpus heterophyllus L.) protein hydrolysates as a stabilizer of the nanoemulsions loaded with extract-rich in pentacyclic triterpenes obtained from Coccoloba uvifera L. leaf

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