Topical delivery of acetazolamide by encapsulating in mucoadhesive nanoparticles

Manchanda, Satish; Sahoo, PK

doi:10.1016/j.ajps.2017.04.005

Cited by 33 publications

(26 citation statements)

References 29 publications

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“…This may be attributed to the fact that more polymers can encapsulate more drugs, and more TPP accelerates entrapment by increasing the crosslinking contact [145]. As expected, decreasing the CS/TPP ratio leads to a decrease of entrapment [136,139,145].…”

Section: Drug Encapsulation and Releasementioning

confidence: 51%

“…PDI has been found to be dependent on CS and TPP concentrations. Generally, as either concentration increases, the PDI increases [133,136,140,146]. Badiee et al reported a slight increase in PDI from 0.25 to 0.42 when the CS concentration increased, but there was an important reduction from 0.41 to 0.24 when the TPP concentration increased [132].…”

Section: Cs/tppmentioning

confidence: 97%

“…A direct correlation of CS and TPP concentrations with particle size has been observed. Most authors report that increasing CS concentration results in an augmentation in particle size [133,135,136,140,142]. As CS concentration increases, CS molecules are closer to each other, resulting in an increase in intermolecular crosslinking (H-bonding) and thus larger particles [133,143,144].…”

Section: Cs/tppmentioning

confidence: 99%

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Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

et al. 2020

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Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.

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Section: Drug Encapsulation and Releasementioning

confidence: 51%

Section: Cs/tppmentioning

confidence: 97%

Section: Cs/tppmentioning

confidence: 99%

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Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

et al. 2020

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“…It was observed that Carbopol gel has better release than colloidal silica gel and both the gels were best fitted to zeroorder model. [22] Ex vivo retention studies of optimized formulation of NA…”

Section: Ex Vivo Permeation Studiesmentioning

confidence: 99%

Untitled

Mehta¹

2018

AJP

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Introduction: Nicotinamide (NA) has shown potential benefits in acne vulgaris, photodamage, cellulite, and atopic dermatitis. Aim: In this study, a topical microemulsion based gel (MBG) of NA has been prepared. Materials and Methods: Microemulsion was composed of NA, Peppermint oil, Tween 20, and distilled water. The microemulsion was converted into MBGs using various concentrations of hydrophilic colloidal silica and Carbopol 934P. MBGs which were found to be the most stable ones were evaluated for further parameters. Results: MBGs with 4.1% hydrophilic colloidal silica and 1.1% Carbopol 934P were observed to be most stable after stability studies and were further assessed for rheology, spreadability, bioadhesion, and ex-vivo release and retention. The results connoted that MGB colloidal silica 4.1% was clear and MBG Carbopol 934P 1.1% was translucent, both with shear thinning properties. The ex vivo evaluation using pig ear skin was performed for both the gels to study the drug release and drug retention in comparison to NA solution. The release kinetics was fitted to zero-order model. The drug release and retention were higher in the following order MBG Carbopol >MBG Colloidal Silica >NA solution. Conclusion: The study indicates that MBG can be an effective system for topical delivery of NA.

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“…Chitosan (CS), a cationic polysaccharide with good biocompatibility and biodegradability, is generally regarded as an excellent drug carrier. 6,7 As for the selection of protein as part of the nanocarrier for virus mimicking, amino acids with different functional side chains (R group), which are the monomeric units of protein, might be an option. To the best of our knowledge, although some amino acidsemodified CS copolymers have been reported, they have been mainly used for tissue engineering and gene delivery.…”

Section: Introductionmentioning

confidence: 99%

Design of Virus-Mimicking Polyelectrolyte Complexes for Enhanced Oral Insulin Delivery

Liu

Sun

et al. 2019

Journal of Pharmaceutical Sciences

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Topical delivery of acetazolamide by encapsulating in mucoadhesive nanoparticles

Cited by 33 publications

References 29 publications

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Untitled

Design of Virus-Mimicking Polyelectrolyte Complexes for Enhanced Oral Insulin Delivery

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