Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells in vitro: potential role for patients with cancer therapy induced mucositis?

Lüer, Sonja; Troller, Rolf; Jetter, Marion; Spaniol, Violeta; Aebi, Christoph

doi:10.1007/s00520-010-0894-x

Cited by 25 publications

(30 citation statements)

References 35 publications

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“…63 Turmeric/curcumin has also been reported to possess antimicrobial effects, including against the clinically relevant methicillinresistant Staphylococcus aureus strains 64 With regard to the bacteria involved in the process of oral mucositis, in vitro studies with Moraxella catarrhali, a facultative upper respiratory tract pathogen have shown that curcumin possess bactericidal effects to inhibit bacterial adherence and invasion to Detroit 562 (pharyngeal cells) and to reduce Mcat-induced pro-inflammatory activation by suppressing release of pro-inflammatory cytokine IL-8. 65 Pre-incubation of Detroit cells with 200 µM curcumin for 5 to 60 minutes resulted in complete suppression of the release of tumor necrosis factor-α, IL-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor. 65 Additionally, the investigators have also observed that repetitive exposure to curcumin caused recurring suppression of cytokine/ chemokine expression.…”

Section: Discussionmentioning

confidence: 97%

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer

et al. 2013

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Purpose. Radiation-induced oral mucositis is an acute morbidity seen in patients undergoing treatment for head and neck cancers. In this study, we evaluated the efficacy of turmeric in preventing radiation-induced mucositis. Methods. This was a single-blinded, randomized, controlled clinical trial and was conducted with head and neck cancer patients requiring 70 Gy of radiation or chemoradiotherapy (daily radiotherapy plus carboplatin once a week). Eligible patients (n = 80) were randomly assigned to receive either turmeric gargle (n = 40) or povidone-iodine ([n = 40] active comparator condition) during chemo/radiotherapy during the period of treatment. Oral mucositis was assessed using the RTOG (Radiation Therapy Oncology Group) grading system before the start, during, and at the end of the treatment by an investigator unaware of the treatment. The primary endpoint of this study was the incidence of mucositis every week during the 7-week period. The secondary endpoint was the effect of turmeric gargle on the incidence of treatment breaks, loss of scheduled treatment days, and decrease in body weight at the end of the treatment. Results. This study clearly suggests that when compared with the cohorts using povidone-iodine gargle, the group using turmeric as a mouthwash had delayed and reduced the levels of radiation-induced oral mucositis and was statistically significant at all time points (P < 0.001 to P < 0.0001). Additionally, the cohorts using turmeric had decreased intolerable mucositis (P < 0.001) and lesser incidence of treatment breaks in the first half of the treatment schedule before 4 weeks (P < 0.01) and reduced change in body weight (P < 0.001). Conclusions. Gargling with turmeric by head and neck cancer patients undergoing radiation therapy provided significant benefit by delaying and reducing the severity of mucositis. Turmeric is readily available, relatively inexpensive, and highly accepted making it useful in cancer treatment.

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Section: Discussionmentioning

confidence: 97%

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer

et al. 2013

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“…The human pharyngeal epithelial cell line Detroit 562 (ATCC CCL 138) was cultured as published earlier in MEM supplemented with 10% of heat-inactivated fetal calf serum (FCS), 2 mM of L-glutamine (Invitrogen, Basel, Switzerland), 1% sodium bicarbonate (Invitrogen, Basel, Switzerland), 1× MEM non-essential amino acid solution (Sigma, St. Louis, MO, USA), 1 mM sodium pyruvate (Sigma, St. Louis, MO, USA), 100 μg/ml streptomycin and 100 U/ml penicillin at 37°C in 5% CO 2 [26]. Cells were grown in 24-well plates to a confluent cell layer (≈3×10 5 cells per well).…”

Section: Methodsmentioning

confidence: 99%

The Pneumococcal Polysaccharide Capsule and Pneumolysin Differentially Affect CXCL8 and IL-6 Release from Cells of the Upper and Lower Respiratory Tract

et al. 2014

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The polysaccharide capsule and pneumolysin toxin are major virulence factors of the human bacterial pathogen Streptococcus pneumoniae. Colonization of the nasopharynx is asymptomatic but invasion of the lungs can result in invasive pneumonia. Here we show that the capsule suppresses the release of the pro-inflammatory cytokines CXCL8 (IL-8) and IL-6 from the human pharyngeal epithelial cell line Detroit 562. Release of both cytokines was much less from human bronchial epithelial cells (iHBEC) but levels were also affected by capsule. Pneumolysin stimulates CXCL8 release from both cell lines. Suppression of CXCL8 homologue (CXCL2/MIP-2) release by the capsule was also observed in vivo during intranasal colonization of mice but was only discernable in the absence of pneumolysin.When pneumococci were administered intranasally to mice in a model of long term, stable nasopharyngeal carriage, encapsulated S. pneumoniae remained in the nasopharynx whereas the nonencapsulated pneumococci disseminated into the lungs.Pneumococcal capsule plays a role not only in protection from phagocytosis but also in modulation of the pro-inflammatory immune response in the respiratory tract.

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“…In addition, it exhibits significant antimicrobial activity in vitro against a number of Gram-negative and Grampositive bacteria such as Bacillus subtilis, Escherichia coli, Helicobacter pylori, Salmonella enterica serovar Typhimurium, and some Staphylococcus aureus strains [12][13][14][15]. In vitro experiments with human oropharyngeal cells have demonstrated that curcumin has considerable inhibitory effect against bacteria in the upper respiratory tract, thus, affecting their growth, adherence, invasion, and pro-inflammatory activation [16].…”

Section: Introductionmentioning

confidence: 99%

Curcumin suppresses Streptococcus mutans adherence to human tooth surfaces and extracellular matrix proteins

Song

Choi

Jin

et al. 2011

Eur J Clin Microbiol Infect Dis

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Streptococcus mutans is the key causative agent of caries and infective endocarditis. The first step in biofilm development and the consequent initiation of further disease is bacterial adherence to host cell surfaces. Therefore, the aim of this study was to evaluate the inhibitory effect of curcumin on S. mutans adherence to extracellular matrices and tooth surfaces. The effect of curcumin on the ability of S. mutans to adhere to glass surfaces coated with collagen and fibronectin was tested in order to determine whether the decrease of the bacterial adhesion by curcumin is achieved by hindering the bacteria in adhering to collagen and/or fibronectin. Also, human teeth inoculated with S. mutans were treated with curcumin in vitro in order to assess the relevance of the anti-adhesive effect to oral conditions in vivo. The minimum inhibitory concentration (MIC) at which curcumin completely inhibited bacterial growth was 128 μg/mL. The addition of curcumin below the MIC diminished bacterial adherence onto both collagen- and fibronectin-coated glass surfaces and human tooth surfaces. It appears that the anti-adhesive effect of curcumin against S. mutans is mediated through collagen and fibronectin. These results support the widespread use of curcumin as a food-based antimicrobial agent.

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Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells in vitro: potential role for patients with cancer therapy induced mucositis?

Cited by 25 publications

References 35 publications

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer

The Pneumococcal Polysaccharide Capsule and Pneumolysin Differentially Affect CXCL8 and IL-6 Release from Cells of the Upper and Lower Respiratory Tract

Curcumin suppresses Streptococcus mutans adherence to human tooth surfaces and extracellular matrix proteins

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