Topical cream containing live lactobacilli decreases malodor‐producing bacteria and downregulates genes encoding PLP‐dependent enzymes on the axillary skin microbiome of healthy adult Nigerians

Onwuliri, Victoria; Agbakoba, Nneka Regina

doi:10.1111/jocd.13949

Cited by 14 publications

(8 citation statements)

References 23 publications

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“…Well-characterized probiotic strain linked with microbiome modulation upon oral and topical skin application [48,49] Limosilactobacillus reuteri RC14…”

Section: Human Vaginal Isolatementioning

confidence: 99%

Live biotherapeutic throat spray for respiratory virus inhibition and interferon pathway induction

Spacova

Boeck

Cauwenberghs

et al. 2022

Preprint

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Respiratory viruses such as influenza viruses, respiratory syncytial virus (RSV), and coronaviruses initiate infection at the mucosal surfaces of the upper respiratory tract (URT), where the resident respiratory microbiome has an important gatekeeper function. In contrast to gut-targeting administration of beneficial bacteria against respiratory viral disease, topical URT administration of probiotics is currently underexplored, especially for the prevention and/or treatment of viral infections. Here, we report the selection and formulation of a broad-acting throat spray with live lactobacilli which induce interferon regulatory pathways and are able to inhibit respiratory viruses. Rational selection of Lactobacillaceae strains was based on safety, applicability, and potential antiviral and immunostimulatory efficacy in the URT. Three strains, Lacticaseibacillus casei AMBR2, Lacticaseibacillus rhamnosus GG and Lactiplantibacillus plantarum WCFS1 significantly reduced the cytopathogenic effects of RSV, influenza A/H1N1 and B viruses, and HCoV-229E coronavirus in co-culture models with bacteria, virus and host cells. Subsequently, these strains were formulated in a throat spray and human monocytes were employed to confirm the formulation process did not reduce the interferon regulatory pathway-inducing capacity. Administration of the throat spray in healthy volunteers revealed that the lactobacilli were capable of temporary colonization of the throat in a metabolically active form.

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“…Well-characterized probiotic strain linked with microbiome modulation upon oral and topical skin application [48,49] Limosilactobacillus reuteri RC14…”

Section: Human Vaginal Isolatementioning

confidence: 99%

Live biotherapeutic throat spray for respiratory virus inhibition and interferon pathway induction

Spacova

Boeck

Cauwenberghs

et al. 2022

Preprint

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“…Corynebacterium is a major genus of skin microbiota that is reported as predominant on moist skin [1]. Some Corynebacterium species, including C. tuberculostearicum, are reported as causal agents of axillary odor [47]. It is also reported in the literature as involved in human skin diseases, including tinea pedis [48].…”

Section: Discussionmentioning

confidence: 99%

A Hylocereus undatus Extract Enhances Skin Microbiota Balance and Delivers In-Vivo Improvements in Skin Health and Beauty

Havas,

Krispin,

Cohen

et al. 2024

Cosmetics

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Skin microbiota, and its diversity and balance, play a key role in skin health and beauty, influencing skin moisture, barrier function, and radiance. A healthy skin microbiota limits the growth of detrimental species, protecting the skin from pathologies. Prebiotics can support beneficial populations in outcompeting detrimental ones. Dragon fruit (Hylocereus undatus) contains prebiotic polysaccharides effective on gut bacteria. Its extract was tested in vitro, in a coculture model including representative beneficial and detrimental species, and in double-blind, placebo-controlled clinical trials. Effects on the skin microbiota were measured via 16S rDNA sequencing, and skin health and beauty benefits were evaluated through image analysis, TEWL measurement, and chromametry. Doppler flowmetry measured skin resilience. The extract supported S. epidermidis and S. hominis (beneficial species), while limiting S. aureus and C. acnes (representing pathogens) in vitro. Clinical results demonstrated its beneficial effects on skin microbiota diversity, especially in older volunteers (Faith’s index up to +20% vs. placebo). Improvements were shown in skin sensitivity and resilience (by ca. 30% vs. placebo), skin redness (reflecting inflammation status), pigmentation and radiance (+11% ITA), barrier function (−13% TEWL), and wrinkling. This demonstrates this extract’s positive effects on the beauty, health, and microbiota balance of the skin.

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“…At present, there are relatively few studies on the effects of probiotics on body odor, but their effect on improving body odor should not be ignored. Victoria Onwuliri MSc 64 et al have shown that Lactobacillus Pentosus KCA1 is effective at improving body odor. The main mechanism of action is by changing the composition of microorganisms in the axilla.…”

Section: Effects Of Probiotics In Skin Carementioning

confidence: 99%

Application and mechanism of probiotics in skin care: A review

Wang

et al. 2022

J of Cosmetic Dermatology

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Recently, the concept of micro-ecological skin care has gradually been into people's life, which means that people have entered a new era in skin care. Micro-ecological skin care mainly refers to the improvement of skin barrier function and cell combination, accelerating of skin renewal and improvement of skin health by supplementing probiotics or prebiotics. 1 Probiotics are defined as living microorganisms which, when administered in adequate amounts, give a healthy benefit on the host. 2 Reports on the use of probiotics can be traced back to 1907. 3 In recent years, probiotics have been widely studied by researchers because of their beneficial effects in many aspects. There are many kinds of probiotics, among which Lactobacillus, Bifidobacterium, and Streptococcus and so on are widely used and studied. Probiotics have a wide range of functions. For example, they can maintain the immune balance of gastrointestinal tract, treat gastrointestinal diseases. 4 At the same time, it also has the function of alleviating anxiety, depression, and obesity. 5,6 And beyond that, probiotics cannot be underestimated in the treatment of skin diseases, such as atopic dermatitis, acne, rosacea, psoriasis and so on. [7][8][9] It can treat skin diseases by producing certain cytokine analogs that inhibit the growth of pathogenic bacteria. [10][11][12] Treatment can also be achieved by regulating the immune system and improving the skin barrier. 13,14 Nowadays, there are many probiotic products on the market and they are widely used in the clinic.People's pursuit of beauty never stops. Skin problems such as skin hyperpigmentation, skin wrinkles, skin aging and skin dehydration caused by some external factors or people's own reasons are always puzzling people. There are many reasons for these skin problems, and researchers are constantly developing safe and effective skin-care products to solve these skin problems. Nowadays, many cosmetics are added with chemicals, such as titanium dioxide, which are more or less toxic and may have adverse effects on

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Topical cream containing live lactobacilli decreases malodor‐producing bacteria and downregulates genes encoding PLP‐dependent enzymes on the axillary skin microbiome of healthy adult Nigerians

Cited by 14 publications

References 23 publications

Live biotherapeutic throat spray for respiratory virus inhibition and interferon pathway induction

Live biotherapeutic throat spray for respiratory virus inhibition and interferon pathway induction

A Hylocereus undatus Extract Enhances Skin Microbiota Balance and Delivers In-Vivo Improvements in Skin Health and Beauty

Application and mechanism of probiotics in skin care: A review

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