Topical Corticosteroids: Pharmacology

Kwatra, Gagandeep; Mukhopadhyay, Sandip

doi:10.1007/978-981-10-4609-4_2

Cited by 19 publications

(16 citation statements)

References 32 publications

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“…An appropriate topical corticosteroid is selected on the basis of the dermatological condition to be treated, patientrelated factors and the physicochemical properties of the drug. Their use is associated with mainly local adverse drug reactions, but prolonged use and/or use of high-potency topical corticosteroids may cause systemic effects [22,23].…”

Section: Resultsmentioning

confidence: 99%

Awareness on Topical Corticosteroids among Dental Students

Muthukumar

Ganapathy

2020

JPRI

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Topical corticosteroids play a major role in the treatment of many dermatologic conditions. They are FDA-approved and indicated for the use of inflammatory and pruritic presentations of dermatologic conditions. The well-known indications are for diseases such as psoriasis, limited areas of vitiligo, eczema, atopic dermatitis, phimosis, acute radiation dermatitis, lichen planus, lichen simplex chronicus, discoid lupus erythematosus, and lichen sclerosus. They are effective for conditions involving hyper-proliferation, immunological, and inflammatory properties. The aim of the study was to assess the knowledge and awareness of topical corticosteroids among the dental students. The present study was an online-based survey conducted among dental students. Questionnaires were prepared and distributed among dental students through an online portal system called google forms. About 84% of dental students were aware of topical corticosteroids. From the results of the survey, it is clear that most of the dental students were well aware of topical corticosteroids and also had proper knowledge and its complications.

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Section: Resultsmentioning

confidence: 99%

Awareness on Topical Corticosteroids among Dental Students

Muthukumar

Ganapathy

2020

JPRI

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“…In our subset of actives, clobetasol propionate is generally classified as the most potent corticoid even if betamethasone dipropionate has a higher lipophillicity. This is probably due because the free form of betamethasone dipropionate has a lower Log D than the free form of clobetasol propionate because of the hydrolysis of the propionate group …”

Section: Resultsmentioning

confidence: 99%

“…This is probably due because the free form of betamethasone dipropionate has a lower Log D than the free form of clobetasol propionate because of the hydrolysis of the propionate group. 42 The Franz diffusion cell is used to determine the distribution on the skin of three actives (Bet, Clo and Fra) formulated in PG solution and in the following commercial formulations: for Bet, Diproderm® ointment and Diproderm® cream; for Clo, Decloban® ointment and Clovate® cream; and for Fra, Cordran® ointment and Cordran® cream. The concentration of all of the PG and commercial formulations is 0.5 mg/g (Table 1).…”

Section: Resultsmentioning

confidence: 99%

In vitro penetration through the skin layers of topically applied glucocorticoids

Carrer

Alonso

Oliver

et al. 2018

Drug Testing and Analysis

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Corticoids are actives widely used in the treatment of skin diseases. This work aims to study the penetration of 3 corticoids (betamethasone, clobetasol, and flurandrenolide), their relationship with their Log D values and the effects of the vehicles. The 3 compounds were applied on a Franz-type diffusion cell in propylene glycol solution and their respective commercial creams and ointments. The active amounts found in the stratum corneum, epidermal, and dermal layers of the skin were investigated. Their diffusions were greatly affected by the formulation; moreover higher amounts of substance in the epidermis and dermis were detected in ointments than in creams. The enhancement effect of propylene glycol was also observed. The differences between the 3 substances could be related to their lipophilicity, molecular structure, and molecular weight. The more hydrophobic compounds (clobetasol and betamethasone) are present in higher amounts in the epidermis and dermis, while the hydrophilic compound (flurandrenolide) is mostly present in the receptor fluid.

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“…Corticosteroids have a C21 structure, presenting a steroid nucleus derived from cholesterol [32]. From this backbone, numerous drugs vary from differing functional groups and oxidation states [33].…”

Section: Chemical Familymentioning

confidence: 99%

Recent Advances in the Design of Topical Ophthalmic Delivery Systems in the Treatment of Ocular Surface Inflammation and Their Biopharmaceutical Evaluation

et al. 2020

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Ocular inflammation is one of the most common symptom of eye disorders and diseases. The therapeutic management of this inflammation must be rapid and effective in order to avoid deleterious effects for the eye and the vision. Steroidal (SAID) and non-steroidal (NSAID) anti-inflammatory drugs and immunosuppressive agents have been shown to be effective in treating inflammation of the ocular surface of the eye by topical administration. However, it is well established that the anatomical and physiological ocular barriers are limiting factors for drug penetration. In addition, such drugs are generally characterized by a very low aqueous solubility, resulting in low bioavailability as only 1% to 5% of the applied drug permeates the cornea. The present review gives an updated insight on the conventional formulations used in the treatment of ocular inflammation, i.e., ointments, eye drops, solutions, suspensions, gels, and emulsions, based on the commercial products available on the US, European, and French markets. Additionally, sophisticated formulations and innovative ocular drug delivery systems will be discussed. Promising results are presented with micro- and nanoparticulated systems, or combined strategies with polymers and colloidal systems, which offer a synergy in bioavailability and sustained release. Finally, different tools allowing the physical characterization of all these delivery systems, as well as in vitro, ex vivo, and in vivo evaluations, will be considered with regards to the safety, the tolerance, and the efficiency of the drug products.

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Topical Corticosteroids: Pharmacology

Cited by 19 publications

References 32 publications

Awareness on Topical Corticosteroids among Dental Students

Awareness on Topical Corticosteroids among Dental Students

In vitro penetration through the skin layers of topically applied glucocorticoids

Recent Advances in the Design of Topical Ophthalmic Delivery Systems in the Treatment of Ocular Surface Inflammation and Their Biopharmaceutical Evaluation

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