Topical corticosteroid in foam vehicle offers comparable coverage compared with traditional vehicles

Feldman, Steven R.; Sangha, Namrata; Setaluri, V.

doi:10.1067/mjd.2000.104892

Cited by 22 publications

(4 citation statements)

References 5 publications

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“…A novel foam formulation with enhanced BMV bioavailability has been shown to be superior in efficacy when compared with a lotion in the treatment of disease, without an concomitant increase in toxicity [159]. Another study has been performed comparing the ability of a foam formulation to release the active ingredient (betamethasone benzoate) with ointment, gel, and cream formulations.…”

Section: Foamsmentioning

confidence: 98%

Innovative Topical Formulations for Treatment of Dermatitis

Şenyiğit

Özcan²,

Özer³

2012

IAD

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The treatment of dermatitis with conventional dosage forms (ointment, cream, lotion etc.) has many concerns due to side effects especially in long-term therapy. Recent studies focused on strategies to optimize the potency of formulation while minimizing side effects. Several attempts have been made to increase the safety of treatment, including special vehicles (nanoparticle, liposome, patch etc.), combined therapy and new synthesized agents. This review provides major innovations and advances of new approaches for dermatitis treatment based on the published articles and patent applications.

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Section: Foamsmentioning

confidence: 98%

Innovative Topical Formulations for Treatment of Dermatitis

Şenyiğit

Özcan²,

Özer³

2012

IAD

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“…Recently, foams have shown potential in the treatment of psoriasis. The properties of foams allow a drug to be quickly broken down on the scalp and get into the SC through the roots of the hair, which is suitable for treating scalp psoriasis (Franz et al, 1999;Feldman et al, 2000;Feldman et al, 2001). The rapid evaporation of the foam propellant results in an increase in the surfactant concentration in the remaining foam, thereby increasing the permeability.…”

Section: Foamsmentioning

confidence: 99%

Advances in the Application of Natural Products and the Novel Drug Delivery Systems for Psoriasis

Xie

Huang

et al. 2021

Front. Pharmacol.

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Psoriasis, an incurable autoimmune skin disease, is one of the most common immune-mediated disorders. Presently, numerous clinical research studies are underway, and treatment options are available. However, these treatments focus on improving symptoms of the disease and fail to achieve a radical cure; they also have certain toxic side effects. In recent years, natural products have increasingly gained attention because of their high efficiency and low toxicity. Despite their obvious therapeutic effects, natural products’ biological activity was limited by their instability, poor solubility, and low bioavailability. Novel drug delivery systems, including liposomes, lipospheres, nanostructured lipid carriers, niosomes, nanoemulsions, nanospheres, microneedles, ethosomes, nanocrystals, and foams could potentially overcome the limitations of poor water solubility and permeability in traditional drug delivery systems. Thus, to achieve a therapeutic effect, the drug can reach the epidermis and dermis in psoriatic lesions to interact with the immune cells and cytokines.

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“…The methods for patient's assessment were also adapted from recent studies [12,[15][16][17][18]. Pruritus was given a score from 0 to 4.…”

Section: Methodsmentioning

confidence: 99%

Dithranol in an Emulsifying Oil Base (Bio-Wash-Oil) for the Treatment of Psoriasis of the Scalp

Wulff-Woesten

Ohlendorf²,

Henz³

et al. 2004

Skin Pharmacol Physiol

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On the scalp, dithranol has been studied in only a few trials. The dithranol molecule that contains both hydrophilic and lipophilic centers can be incorporated into detergents and allows easy removal from hair. This property has led to the incorporation of dithranol in an emulsifying oil base (bio-wash-oil). The formulation has been used routinely for more than two decades in East Germany. We reexamined the efficacy and safety of dithranol in bio-wash-oil and compared it to dithranol embedded in crystalline monoglycerides (Micanol^®) in patients with psoriasis of the scalp. In a prospective, parallel group study, 64 patients attending a day-care clinic were randomly allocated to 3 treatment groups: (1) dithranol in bio-wash-oil; (2) Micanol^® cream, and (3) Micanol^® cream in bio-wash-oil. Treatment was carried out for 3 weeks and results assessed using a modified Psoriasis Area and Severity Index score. Dithranol in bio-wash-oil resulted in a reduction in the score of 34% on day 7 and 57% on day 14. This was significantly better than in groups 2 and 3, as were the overall response and patients’ assessment at the end of treatment (p < 0.05). Dithranol in a bio-wash-oil is an effective, well-tolerated and low-priced treatment in psoriasis of the scalp.

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Topical corticosteroid in foam vehicle offers comparable coverage compared with traditional vehicles

Cited by 22 publications

References 5 publications

Innovative Topical Formulations for Treatment of Dermatitis

Innovative Topical Formulations for Treatment of Dermatitis

Advances in the Application of Natural Products and the Novel Drug Delivery Systems for Psoriasis

Dithranol in an Emulsifying Oil Base (Bio-Wash-Oil) for the Treatment of Psoriasis of the Scalp

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