Topical cortical application of ovarian hormones and modulation of brain electrical activity: analysis of spreading depression in well-nourished and malnourished female rats

Accioly, Noranege Epifânio; Guedes, Rubem Carlos Araújo

doi:10.1080/1028415x.2019.1575574

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…Female mice are mature at 3–4 months, sexually mature by 6 months, premenopausal at around 9 months, in the menopause at the age of 12 months, following a reproductive senescence transition between 9 and 12 months 67 . We assume that putative effects of hormonal transitions affect AD pathology (see above) and the development of CSD since publications have shown the influence and increase in excitability and rate of CSD induced by female hormones 68 , fitting to our observations of CSD development and propagation after KCl microinjection. Interestingly, the more pronounced AD pathology in female mice was not mirrored by any major changes in CSD parameters.…”

Section: Discussionsupporting

confidence: 78%

Neuropathological changes in the TASTPM mouse model of Alzheimer’s disease and their relation to hyperexcitability and cortical spreading depolarization

Gimeno-Ferrer,

Eitner,

Noora

et al. 2024

Sci Rep

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Although Alzheimer’s disease (AD) is characterized by distinct pathological changes, their precise impact on cortical functions are not well understood. Here we used TASTPM mice as an AD model and asked whether the development of neurodegenerative changes has an impact on the extracellular space (ECS) and neuronal excitability, in particular cortical spreading depolarization (CSD) which requires intact neuron and glial functions. We studied wildtype (WT) and TASTPM mice (3, 6, and 12 months old). TASTPM mice showed progressive proliferation of neocortical Amyloid-beta (Aβ) plaques between 3 and 12 months (more deposits in females than in males) and Aβ accumulation in cortical vessels. As plaques proliferated, neuroinflammatory microglial reaction (CD68, CD39 and Galectin-3) and astrogliosis (GFAP) developed progressively. The cortical ECS volume shrank significantly to about half the size of the WT. CSD in both WT and TASTPM mice showed considerable heterogeneity but did not correlate with the histological changes. However, CSDs were easier to elicit in TASTPM than in WT mice at 3 months, and also compared to older TASTPM mice. Moreover, TASTPM mice showed more hyperexcitability manifested as clonic-tonic behavior after sodium thiopental anesthesia. Thus, AD pathology was associated with abnormal hyperexcitability but did not homogenously alter CSD susceptibility.

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Section: Discussionsupporting

confidence: 78%

Neuropathological changes in the TASTPM mouse model of Alzheimer’s disease and their relation to hyperexcitability and cortical spreading depolarization

Gimeno-Ferrer,

Eitner,

Noora

et al. 2024

Sci Rep

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“…The floor was painted with lines to distinguish four quadrants, and the center was defined by a circle (62 cm diameter). The evaluated parameters were distance traveled, immobility time, central zone entries, and central zone time [17].…”

Section: Open Field Testmentioning

confidence: 99%

“…A central 10 × 10 cm square platform joined the arms of the apparatus. The test began with each rat placed individually in the central platform, facing one of the open arms, and freely exploring the maze for 5 min [17]. The parameters considered were the distance traveled, immobility time, open arm entries, and open arm time [17].…”

Section: Elevated Plus Maze Testmentioning

confidence: 99%

Treadmill Exercise Reverses the Adverse Effects of Intermittent Fasting on Behavior and Cortical Spreading Depression in Young Rats

Braz,

Figueira de Oliveira,

Costa

et al. 2023

Brain Sciences

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Intermittent fasting (IF) and physical exercise (PE) have beneficial psychological and physiological effects, improving memory and anxiety-like behavior. However, the impact of this combination on brain electrophysiological patterns is unknown. We aimed to evaluate the behavior and parameters of a brain excitability-related phenomenon named cortical spreading depression (CSD) in young rats (31–87 days of life) submitted to IF and treadmill PE for eight weeks. Sixty-four male and female Wistar rats aged 24 days were randomized into control, IF, PE, and IF+PE groups. Behavioral tests (open field (OF), object recognition, and elevated plus maze (EPM)) were performed, and the CSD propagation features were recorded. IF caused behavioral responses indicative of anxiety (lower number of entries and time spent in the OF center and EPM open arms). IF also reduced the discrimination index for object recognition memory tests and increased the propagation velocity of CSD. PE rats displayed more entries into the OF center and lowered CSD propagation speed. Data suggest that IF worsens anxiety-like behavior and memory and accelerates CSD in young rats. In contrast, PE reverted the unfavorable effects of IF. The brain effects of IF and PE at younger ages are recommended for study.

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“…Although we recognize sex as an essential biological variable on the effects of endogenous melatonin (Kawabata-Sakata et al, 2020), our study included only male rats. This limitation occurred because the hormonal oscillations of the female rat due to the estrous cycle are fast and complex and can alter the parameters that we addressed currently, including CSD (Accioly and Guedes, 2020). The need to use males only becomes even more evident when we use rats in the age of sexual maturation (i.e., from PND 35;Sengupta, 2013).…”

Section: Animal's Sexmentioning

confidence: 99%

Effect of neonatal melatonin administration on behavioral and brain electrophysiological and redox imbalance in rats

Araújo,

Figueira-de-Oliveira,

Noya

et al. 2023

Front. Neurosci.

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IntroductionMelatonin (MLT) reportedly has beneficial effects in neurological disorders involving brain excitability (e.g., Epilepsy and Migraine) and behavioral patterns (e.g., Anxiety and Depression). This study was performed to investigate, in the developing rat brain, the effect of early-in-life administration of two different doses of exogenous MLT on behavioral (anxiety and memory) and electrophysiological (CSD analysis) aspects of brain function. Additionally, brain levels of malondialdehyde (MDA) and superoxide dismutase (SOD), both cellular indicators of redox balance status, were evaluated. We hypothesize that MLT differentially affects the behavioral and CSD parameters as a function of the MLT dose.Materials and methodsMale Wistar rats received, from the 7th to the 27th postnatal day (PND), on alternate days, vehicle solution, or 10 mg/kg/or 40 mg/kg MLT (MLT-10 and MLT-40 groups), or no treatment (intact group). To perform behavioral and cognition analysis, from PND30 to PND32, they were tested in the open field apparatus, first for anxiety (PND30) and then for object recognition memory tasks: spatial position recognition (PND31) and shape recognition (PND32). On PND34, they were tested in the elevated plus maze. From PND36 to 42, the excitability-related phenomenon known as cortical spreading depression (CSD) was recorded, and its features were analyzed.ResultsTreatment with MLT did not change the animals’ body weight or blood glucose levels. The MLT-10 treatment, but not the MLT-40 treatment, was associated with behaviors that suggest less anxiety and improved memory. MLT-10 and MLT-40 treatments, respectively, decelerated and accelerated CSD propagation (speed of 2.86 ± 0.14 mm/min and 3.96 ± 0.16 mm/min), compared with the control groups (3.3 ± 0.10 mm/min and 3.25 ± 0.11 mm/min, for the intact and vehicle groups, respectively; p < 0.01). Cerebral cortex levels of malondialdehyde and superoxide dismutase were, respectively, lower and higher in the MLT-10 group but not in the MLT40 group.ConclusionOur findings suggest that MLT intraperitoneal administration during brain development may differentially act as an antioxidant agent when administered at a low dose but not at a high dose, according to behavioral, electrophysiological, and biochemical parameters.

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Topical cortical application of ovarian hormones and modulation of brain electrical activity: analysis of spreading depression in well-nourished and malnourished female rats

Cited by 3 publications

References 27 publications

Neuropathological changes in the TASTPM mouse model of Alzheimer’s disease and their relation to hyperexcitability and cortical spreading depolarization

Neuropathological changes in the TASTPM mouse model of Alzheimer’s disease and their relation to hyperexcitability and cortical spreading depolarization

Treadmill Exercise Reverses the Adverse Effects of Intermittent Fasting on Behavior and Cortical Spreading Depression in Young Rats

Effect of neonatal melatonin administration on behavioral and brain electrophysiological and redox imbalance in rats

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