Topical combination products for facial acne

Fritsch, Paul; Jardine, Stacy; Kolber, Michael R.

doi:10.46747/cfp.6806445

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…This has prompted discussions around screening younger patients (6) and ultimately, decisions by the American Cancer Society (7), the United States Preventive Services Task Force (8), the United States Multi Society Task Force (9), and the National Comprehensive Cancer Network to recommend reducing the age to start average risk CRC screening from 50 to 45 years. In Canada, recommendations to start CRC screening earlier has not yet occurred (10). To inform the Canadian guidelines on this important topic, our group has identified several research gaps that need to be addressed (11).…”

Section: Introductionmentioning

confidence: 99%

Early-Onset Colorectal Cancer Incidence, Staging, and Mortality in Canada: Implications for Population-Based Screening

et al. 2022

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INTRODUCTION: The incidence of early-onset colorectal cancer (eoCRC) has been increasing in North America. Debate remains as to whether the trends by topography, histology, stage, or mortality in this population are amenable to intervention from screening. METHODS: CRC incidence (2000-2017) and mortality (2000-2018) data were obtained from the Canadian Cancer Registry and Vital Statistics. Annual percentage changes (APC) in the incidence (topography and histology) and mortality of eoCRC were estimated using joinpoint regression. Incidence of latestage CRC (III or IV) versus early-stage CRC (I or II) was compared between the eoCRC (age 20-49 years) and eligible screening (age 50-74 years) groups with Poisson regression. RESULTS:Among women aged 20-49 years, the incidence of CRC significantly increased from 2000 to 2017 in both the distal colon (APC 5 1.40) and rectum (APC 5 3.00), whereas for men aged 20-49 years, the CRC incidence increased in the proximal colon (APC 5 1.10), distal colon (APC 5 3.00), and rectum (APC 5 3.70). Among both men and women aged 20-49 years, the incidence of nonmucinous adenocarcinomas significantly increased (APC: 1.90 and 2.30, respectively), whereas mucinous adenocarcinomas decreased for women (APC 5 21.60) and remained stable for men. Adults aged 30 to 49 years, when diagnosed with CRC, had a significantly higher risk of being diagnosed with a late-stage CRC compared with those in the age group of 50-74 years. Rectal cancer mortality increased from 2000 to 2018 in the eoCRC group (APC for women and men 3.80 and 3.40, respectively).

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Section: Introductionmentioning

confidence: 99%

Early-Onset Colorectal Cancer Incidence, Staging, and Mortality in Canada: Implications for Population-Based Screening

et al. 2022

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“…Recent meta-analyses have found that antidepressants—particularly tricyclics and selective serotonin reuptake inhibitors—improve global IBS symptoms as well as abdominal pain [ 153 ]. While SSRIs demonstrate a statistically significant benefit for improvement of global symptoms, TCAs appear to have an advantage in improvement of abdominal pain and symptom score [ 154 ].…”

Section: The Human Gut Microbiomementioning

confidence: 99%

Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review

Shaikh

Sun

Canakis

et al. 2023

JCM

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Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal pain and altered bowel habits. It has a prevalence of 10 to 25% in the United States and has a high disease burden, as evidenced by reduced quality of life, decreased work productivity and increased healthcare utilization and costs. IBS has been associated with several intra-intestinal and extra-intestinal conditions, including psychiatric comorbidities. Although the pathophysiology of IBS has not been fully elucidated, it involves dysregulation of communication between the brain and gut (brain–gut axis) which is associated with alterations in intestinal motility, gut permeability, visceral hypersensitivity and gut microbiota composition. The purpose of this article is to review the role the gut microbiota plays in the pathophysiology of IBS, understand factors that affect the gut microbiome and explore the microbiome as a target of treatment.

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Topical combination products for facial acne

Cited by 2 publications

References 8 publications

Early-Onset Colorectal Cancer Incidence, Staging, and Mortality in Canada: Implications for Population-Based Screening

Early-Onset Colorectal Cancer Incidence, Staging, and Mortality in Canada: Implications for Population-Based Screening

Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review

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