Topical Clindamycin in Acne Vulgaris

Algra, Ronald J.

doi:10.1001/archderm.1977.01640100068011

Arch Dermatol

1977

DOI: 10.1001/archderm.1977.01640100068011

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Topical Clindamycin in Acne Vulgaris

Ronald J. Algra¹

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1979

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Cited by 26 publications

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Topical clindamycin treatment of acne. Clinical, surface lipid composition, and quantitative surface microbiology response

Thomsen¹

1980

Archives of Dermatology

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A double-blind study has been conducted to examine the effect of topical 1% clindamycin hydrochloride hydrate in a hydroalcoholic vehicle as compared to the effect of the vehicle alone. Fourteen patients applied clindamycin or vehicle alone twice daily for eight weeks. Free fatty acid surface lipid percentages, quantitative bacterial counts, and clinical response were assessed every two weeks. A significant reduction (88%) in the percentage of free fatty acids in the surface lipids was seen in the clindamycin-treated group and not in the vehicle-treated group. There was no significant change in the surface microflora. Despite the short duration of treatment, objective clinical improvement was seen in three of nine treated patients, while none was observed in the placebo-treated patients.

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Topical clindamycin treatment of acne. Clinical, surface lipid composition, and quantitative surface microbiology response

Thomsen¹

1980

Archives of Dermatology

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Topical Antibiotics for Acne Vulgaris

Stoughton¹

1979

Arch Dermatol

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Induction of Colitis in Hamsters by Topical Application of Antibiotics

Feingold¹,

Chen²,

Chou³

et al. 1979

Arch Dermatol

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Topical Clindamycin in Acne Vulgaris

Cited by 26 publications

References 13 publications

Topical clindamycin treatment of acne. Clinical, surface lipid composition, and quantitative surface microbiology response

Topical clindamycin treatment of acne. Clinical, surface lipid composition, and quantitative surface microbiology response

Topical Antibiotics for Acne Vulgaris

Induction of Colitis in Hamsters by Topical Application of Antibiotics

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