Topical Chinese herbal medicine in treating atopic dermatitis (eczema): A systematic review and meta-analysis with core herbs exploration

Wang, Meng-Chun; Chou, Yu-Ting; Kao, Ming-Chen; Lin, Qian; Chang, Sing-Ya; Chen, Hsing-Yu

doi:10.1016/j.jep.2023.116790

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…Topical glucocorticoid preparations are still the mainstay of eczema treatment, and antihistamines can be appropriately selected according to the patient’s condition to relieve itching and inflammation[ 4 ]. Traditional Chinese medicine (TCM) characteristic therapy offers unique properties and advantages that would help treat and prevent eczema[ 5 ]. Li et al [ 6 ] found that the Gu-Ben-Hua-Shi formula can significantly improve atopic dermatitis symptoms in mice.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of acupoint injection in the treatment of chronic eczema and its influence on peripheral blood T cells

Gan,

Yang,

Shen

2024

World J Clin Cases

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BACKGROUND Chronic eczema significantly impacts daily life, social interactions, and quality of life; however, no curative treatment has been identified. AIM To determine the clinical efficacy of acupoint injection for chronic eczema and its influence on peripheral blood T cells. METHODS Eighty patients with chronic eczema treated at our hospital between June 2022 and March 2023 were randomly assigned to a control group (n = 40), which received conventional Western medicine treatment, or an observation group (n = 40), which received routine Western medicine treatment plus acupoint injection of triamcinolone acetonide. Response and adverse reaction rates, as well as differences in the levels of serum cytokines IFN-γ, IL-2, IL-4, and IL-10 before and after treatment were investigated. RESULTS No difference in overall response rates were found between the observation and control groups (100% vs 90%, respectively; P > 0.05); however, the observation group had a higher marked response rate than the control group (87.5% vs 52.5%; P < 0.05). Both groups had decreased Eczema Area and Severity Index scores and increased pruritus after treatment (P < 0.05), particularly in the observation group (P < 0.05). The observation group had an adverse reaction rate of 2.5% (1/40), which did not differ significantly from that of the control group (P > 0.05). The observation group exhibited higher post-treatment INF-γ and IL-2 but lower IL-4 levels than the control group (P < 0.05); however, no significant inter-group difference was observed in post-treatment IL-10 levels (P > 0.05). CONCLUSION Acupoint injection of triamcinolone acetonide is safe and effective in treating chronic eczema. Its therapeutic mechanism is related to the regulation of peripheral blood T cell levels, inhibition of inflammatory reactions, and mitigation of immune imbalance.

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Section: Introductionmentioning

confidence: 99%