Topical capsaicin therapy for osteoarthritis pain: Achieving a maintenance regimen

Schnitzer, Thomas J.; Morton, Cindy; Coker, Steven B.

doi:10.1016/s0049-0172(10)80024-1

Cited by 37 publications

(44 citation statements)

References 7 publications

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“…27 28 One, the only single blind trial, was an active controlled trial comparing different doses of capsaicin 27. Validity scores ranged from nine to 14.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of topical capsaicin for the treatment of chronic pain

Mason

Moore

Derry

et al. 2004

BMJ

380

180

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Objective To determine the efficacy and safety of topically applied capsaicin for chronic pain from neuropathic or musculoskeletal disorders. Data sources Cochrane Library, Medline, Embase, PubMed, an in-house database, and contact with manufacturers of topical capsaicin. Study selection Randomised controlled trials comparing topically applied capsaicin with placebo or another treatment in adults with chronic pain. Data extraction Primary outcome was dichotomous information for the number of patients with about a 50% reduction in pain. Outcomes were extracted at four weeks for musculoskeletal conditions and eight weeks for neuropathic conditions. Secondary outcomes were adverse events and withdrawals due to adverse events. Data synthesis Six double blind placebo controlled trials (656 patients) were pooled for analysis of neuropathic conditions. The relative benefit from topical capsaicin 0.075% compared with placebo was 1.4 (95% confidence interval 1.2 to 1.7) and the number needed to treat was 5.7 (4.0 to 10.0). Three double blind placebo controlled trials (368 patients) were pooled for analysis of musculoskeletal conditions. The relative benefit from topical capsaicin 0.025% or plaster compared with placebo was

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“…27 28 One, the only single blind trial, was an active controlled trial comparing different doses of capsaicin 27. Validity scores ranged from nine to 14.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of topical capsaicin for the treatment of chronic pain

Mason

Moore

Derry

et al. 2004

BMJ

380

180

View full text Add to dashboard Cite

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“…Although no serious side effects were reported, localized burning was the most commonly reported adverse effect; an incidence of approximately 50% was reported in two of the studies. 71,72 However, this tended to regress with time. Another study showed that the coadministration of capsaicin and the topical nitric oxide donor compound, glyceryl trinitrate, had a synergistic analgesic effect and improved tolerability compared with the application of capsaicin alone.…”

Section: Capsaicinmentioning

confidence: 97%

“…Tapering the dose to twice a day has been suggested, based on the results of a two-phase (first phase: four times per day; second phase: twice a day) placebo-controlled study, as a way of improving long-term compliance and reducing cost without compromising efficacy. 71 Several randomized controlled trials have found topical capsaicin to be superior to placebo vehicle for OA pain ( Table 2). Two of these trials specifically addressed hand OA.…”

Section: Capsaicinmentioning

confidence: 99%

Pharmacotherapy of Osteoarthritis

Stitik¹,

Altschuler²,

Foye³

2006

American Journal of Physical Medicine & Rehabilitation

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“…Studies of topical capsaicin cream (0.025%) as monotherapy for osteoarthritis have shown that the compound significantly relieves pain. [34,35] Capsaicin cream is a well tolerated and effective therapy with no systemic adverse effects. It has even been considered as first-line therapy for osteoarthritis pain.…”

Section: Topical Capsaicinmentioning

confidence: 99%

Osteoarthritis in Older Patients

Bagge

Brooks

1995

Drugs & Aging

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A number of therapeutic options to control pain, maintain function and decrease disability are available for older patients with osteoarthritis. The indication for pharmacological therapy should be restricted to periods with pain. Great attention should be given to nonpharmacological interventions such as education, exercise, lifestyle modification and emotional support. If medication is necessary, most patients require only pure analgesics such as paracetamol (acetaminophen); nonsteroidal anti-inflammatory drugs (NSAIDs) should be used if patients do not respond to simpler measures. All medication should be carefully monitored considering the frequency of adverse drug reactions in older patients.

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Topical capsaicin therapy for osteoarthritis pain: Achieving a maintenance regimen

Cited by 37 publications

References 7 publications

Systematic review of topical capsaicin for the treatment of chronic pain

Systematic review of topical capsaicin for the treatment of chronic pain

Pharmacotherapy of Osteoarthritis

Osteoarthritis in Older Patients

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