Topical Betamethasone Treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis with Ocular Involvement in the Acute Phase

Matsumoto, Kaori; Ueta, Mayumi; Inatomi, Tsutomu; Fukuoka, Hideki; Mieno, Hiroki; Tamagawa‐Mineoka, Risa; Katoh, Norito; Kinoshita, Shigeru; Sotozono, Chie

doi:10.1016/j.ajo.2023.05.010

Cited by 7 publications

(1 citation statement)

References 35 publications

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“…Topical steroids and cyclosporine A (CsA) are the most common treatment strategies used to control in ammation 2,3 . Moreover, in acute in ammatory conditions such as chemical or thermal burn, Stevens-Johnson syndrome and ocular graft-versus-host disease, intensive treatment with steroid instillation every few minutes or hours are often mandatory [4][5][6] . However, the effect of the topical drugs on the ocular surface is limited in time due to tear dilution, lacrimal turnover, blinking re ex, nasolacrimal drainage or ocular barriers 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone acetate loaded poly(ε-caprolactone) nanofibers for the treatment of rat corneal chemical burn

Kim,

Park,

Kim

et al. 2024

Preprint

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Nanofibers serve to overcome the limitation of the short duration of action of topical eye drops used against ocular inflammation in dry eyes. Several attempts to develop suitable nanofibers have been made; however, there is no ideal solution. The purpose of this study was to determine the effect of poly(ε-caprolactone) (PCL) nanofibers with encapsulated dexamethasone on alkali-injured cornea in rats. Thirty-nine Sprague Dawley (SD) rats (7 weeks old males) were divided into four treatment groups after alkaline burns of the cornea; negative control (no treatment group); dexamethasone eyedrops (DEX group); PCL fiber (PCL group); dexamethasone loaded PCL (PCL/DEX group). Corneal neovascularization was lower in the group treated with PCL + DEX than in that treated with DEX eyedrops, while PCL alone did not cause corneal neovascularization by irritation or inflammation. Histological analysis revealed lower infiltration of stromal inflammatory cells in corneas treated with PCL + DEX than in those treated with DEX eyedrops. Proinflammatory cytokines, IL-1β, MK2, TGFβ1, TGFβ2, and VEGF-A showed lower expression in corneas treated with PCL + DEX than in those treated with DEX eyedrops. Based on the results, PCL + DEX may be a promising approach to effective drug delivery in corneal burn injuries. In particular, anti-inflammatory function of DEX observed in the acute phase of ocular inflammation appears to be significantly improved on the first day in the PCL + DEX group.

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Section: Introductionmentioning

confidence: 99%