Topical azelaic acid in the treatment of rosacea

Aj, Carmichael; Marks, R.; Graupe, Ka; Zaumseil, R.‐P.

doi:10.3109/09546639309082150

Cited by 53 publications

(55 citation statements)

References 11 publications

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“…It is currently used as a topical 20% cream to treat mild to moderate forms of acne vulgaris; its antibacterial and comedolytic activity is responsible mainly for its beneficial effects. However, controlled comparisons with either placebo 9,10 or topical metronidazole 11 have indicated that 20% azelaic acid cream also has therapeutic effects in rosacea. A direct antiinflammatory effect of azelaic acid, by inhibition of neutrophil-generated reactive oxygen radicals, may account for this beneficial effect.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of 15% Azelaic Acid Gel and 0.75% Metronidazole Gel in the Topical Treatment of Papulopustular Rosacea

Elewski¹,

Fleischer²,

Pariser³

2003

Arch Dermatol

112

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Section: Discussionmentioning

confidence: 99%

A Comparison of 15% Azelaic Acid Gel and 0.75% Metronidazole Gel in the Topical Treatment of Papulopustular Rosacea

Elewski¹,

Fleischer²,

Pariser³

2003

Arch Dermatol

112

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“…Its efficacy is attributed to antibacterial activity, normalization of keratinization and a direct anti-inflammatory effect [73]. In clinical studies in patients with rosacea, topical azelaic acid 20% cream was more effective than its vehicle cream in reducing the number of inflammatory lesions and the degree of erythema [73, 74]. In a randomized, double-blind, vehicle-controlled study in patients with papulopustular rosacea, azelaic acid 20% cream was found to cause a significantly greater decrease in inflammatory lesions (73%) and the erythema severity score after 12 weeks of therapy than did vehicle (50%) [75].…”

Section: Topical Therapymentioning

confidence: 99%

Rosacea: An Update

Buechner¹

2005

Dermatology

118

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Rosacea is a common chronic cutaneous disorder of unknown etiology which occurs most commonly in middle-aged individuals. Cutaneous manifestations include transient or persistent facial erythema, telangiectasia, edema, papules and pustules that are usually confined to the central portion of the face. The National Rosacea Society’s Expert Committee on the Classification and Staging of Rosacea identified four subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous and ocular. Recently, a standard grading system for assessing gradations of the severity of rosacea has been reported. Little is known about the cause of rosacea. Genetic, environmental, vascular, inflammatory factors and microorganisms such as Demodex folliculorum and Helicobacter pylori have been considered. Topical metronidazole and azelaic acid have been demonstrated to be effective treatments for rosacea. Severer or persistent cases may be treated with oral metronidazole, tetracyclines or isotretinoin.

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“…31 Improvement of erythema occurred in 44% and 46% of patients in the azelaic acid groups versus 29% and 28% of vehicle-treated patients. The mean reductions of inflammatory lesions in the azelaic acidetreated patients were 58% and 51%, versus 40% and 39% in control patients.…”

Section: Azelaic Acidmentioning

confidence: 97%

“…Approximately 12% of patients experienced scaling, skin dryness, or rash with the use of azelaic acid gel. 31 In a smaller double-blind, randomized, split-face trial of 40 patients with papulopustular rosacea, the effectiveness of 20% azelaic acid cream was compared with that of topical metronidazole 0.75% cream over a 15-week period. 32 Papule and pustule counts were decreased by 78.5% in the azelaic acid group, compared with 69.4% in the metronidazole group.…”

Section: Azelaic Acidmentioning

confidence: 99%