Topical Application of Siberian Pine Essential Oil Formulations Enhance Diabetic Wound Healing

Nikolic, Milica; Andjic, Marijana; Bradic, Jovana; Kocovic, Aleksandar; Tomovic, Marina; Samanovic, Andjela Milojevic; Jakovljevic, Vladimir; Veselinovic, Mirjana; Capo, Ivan; Krstonosic, Veljko; Kladar, Nebojsa; Petrovic, Anica

doi:10.3390/pharmaceutics15102437

Cited by 9 publications

(2 citation statements)

References 41 publications

(57 reference statements)

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“…cilicic had the strongest wound healing activity in both models used for evaluation (unlike the remainder of EOs, whose activity was negligible) [ 258 ]. Wound healing activity properties were also claimed for the fresh leaf EO of P. sibirica [ 259 ].…”

Section: Pharmacological Interest Of Pinaceae Eosmentioning

confidence: 99%

Antioxidant Activity of Essential Oils from Pinaceae Species

Ancuceanu,

Anghel,

Hovaneț

et al. 2024

Antioxidants

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With a widespread distribution throughout the Northern Hemisphere and 11 genera, Pinaceae is the largest family of Gymnosperms in the world. Essential oils are an important chemotaxonomic marker for the species of this family, although the degree of chemical and biological investigation has not been the same for all genera. Essential oils from Abies and Cedrus (from the abietoid clade) or Pinus and Picea (from the pinoid clade) have been more extensively investigated with respect to their chemical composition and biological or pharmacological properties, including their antioxidant effects. Instead, essential oils from the other genera of the family have been less explored in this respect or even have not been investigated at all. This is a narrative review looking into the knowledge acquired up to date, the variability and limitations of the current methods used to estimate antioxidant effects, and multiple comparisons between EOs obtained from different genera, species, and plant parts, as well as potential applications and future directions of research and utilization of essential oils derived from Pinaceae species.

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Section: Pharmacological Interest Of Pinaceae Eosmentioning

confidence: 99%

Antioxidant Activity of Essential Oils from Pinaceae Species

Ancuceanu,

Anghel,

Hovaneț

et al. 2024

Antioxidants

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“…Clinical studies have also demonstrated the potential of topical antioxidant application in improving diabetic wound healing, highlighting the translational relevance of targeting ROS. 486 , 487 …”

Section: Macrophages: Orchestrators Of Tissue Repair and Regenerationmentioning

confidence: 99%

Macrophage plasticity: signaling pathways, tissue repair, and regeneration

Yan,

Wang,

Cai

et al. 2024

MedComm

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Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt to diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) and alternatively activated (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay of signaling pathways, transcriptional regulators, and epigenetic modifications orchestrates macrophage polarization, allowing them to respond to various stimuli dynamically. Here, we provide a comprehensive overview of the signaling cascades governing macrophage plasticity, focusing on the roles of Toll‐like receptors, signal transducer and activator of transcription proteins, nuclear receptors, and microRNAs. We also discuss the emerging concepts of macrophage metabolic reprogramming and trained immunity, contributing to their functional adaptability. Macrophage plasticity plays a pivotal role in tissue repair and regeneration, with macrophages coordinating inflammation, angiogenesis, and matrix remodeling to restore tissue homeostasis. By harnessing the potential of macrophage plasticity, novel therapeutic strategies targeting macrophage polarization could be developed for various diseases, including chronic wounds, fibrotic disorders, and inflammatory conditions. Ultimately, a deeper understanding of the molecular mechanisms underpinning macrophage plasticity will pave the way for innovative regenerative medicine and tissue engineering approaches.

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