Topical application of (S)-(–)-limonene is as effective as phonophoresis for improving oxidative parameters of injured skeletal muscle in rats

Santos, Magda; Filho, Luís Fernando Sousa; Souza, Jéssica Batista De; Menezes-Filho, José Evaldo Rodrigues de; Mesquita, Thássio; Santos, Marta Silva; Vasconcelos, Carla Maria Lins de; Lauton-Santos, Sandra; Oliveira, Evaleide Diniz de

doi:10.1007/s00210-020-01941-y

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…The ndings revealed that therapeutic ultrasound alone, topical limonene application, and phonophoresis with limonene effectively reduced lipid peroxidation levels and superoxide dismutase activity following the muscle injury. Speci cally, only the combination of phonophoresis with limonene reduced creatine kinase activity after the injury [12]. It's worth noting that the majority of research on α-pinene and β-pinene has focused on their effects on other physiological systems.…”

Section: Discussionmentioning

confidence: 99%

“…One animal study showed that limonene, a commonly used monoterpene, reduced markers of oxidative stress and enzyme activity associated with muscle injury. In addition, a combination treatment with therapeutic ultrasound showed promising results in further reducing oxidative stress [12]. Another monoterpene, camphene, has also shown potential in ameliorating skeletal muscle atrophy by targeting oxidative stress [8].…”

Section: Introductionmentioning

confidence: 99%

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Association between Serum Monoterpene Levels, Hand Grip Strength, and Lean Muscle Mass in a Representative Sample of US Adults: NHANES 2013- 2014

Fang,

Wang,

Lin

2023

Preprint

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Background Monoterpenes, a class of organic compounds with the molecular formula C10H16, have been the subject of considerable research due to their promising medicinal properties. Recent experiments suggest that they may have beneficial effects on skeletal muscles. However, the effects of exposure to monoterpenes on muscle strength and mass in humans remain unknown. Methods To address this knowledge gap, we included 1,202 adults (aged ≥ 18 years) from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) to investigate the potential relationship between serum levels of three specific monoterpenes (α-pinene, β-pinene, and limonene), hand grip strength, and lean muscle mass. Results Our analysis showed that except for test 2 of hand 1, all other grip strength measures showed a positive correlation with ln-limonene levels. The coefficient (ß) for combined grip strength was 2.409 (S.E. = 0.891, P = 0.015). We also observed positive associations between serum limonene levels and lean muscle mass in several areas, including arms, legs, trunk, and total body. The ß coefficient for the appendicular skeletal muscle mass index (ASMI) was 0.138 (S.E. = 0.041, P = 0.004). In addition, we found an interaction between sex and limonene, as well as between body mass index and limonene, with respect to the association with combined grip strength. Conclusions Our findings suggest a plausible association between exposure to limonene, hand grip strength, and lean muscle mass among adults in the United States. Further investigation is needed to fully understand the underlying mechanisms and medical significance of this association.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between Serum Monoterpene Levels, Hand Grip Strength, and Lean Muscle Mass in a Representative Sample of US Adults: NHANES 2013- 2014

Fang,

Wang,

Lin

2023

Preprint

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“…85,86 Santos et al 87 found that limonene applied topically is just as efficient as phonophoresis in restoring the oxidative characteristics of damaged skeletal muscle in rats.…”

Section: Neuroprotective Activitymentioning

confidence: 98%

“…Through the p38 pathway, limonene was found to save human lens epithelial cells from oxidative stress-triggered cell damage and reduce DNA and micronucleus damage caused by H 2 O 2. 85,86 Santos et al 87 found that limonene applied topically is just as efficient as phonophoresis in restoring the oxidative characteristics of damaged skeletal muscle in rats.…”

Section: Pharmacologymentioning

confidence: 99%

The Pharmacological Effects and Potential Applications of Limonene From Citrus Plants: A Review

Chen,

Ding,

Guan

et al. 2024

Natural Product Communications

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The citrus plant is the general term for Citrus, Fortunella, and Poncirus, which includes oranges, tangerines, lemons, grapefruits, and citrons. Not only does it contain a variety of delicious fruits, but it is also an important part of traditional Chinese medicine. Citrus plant peels are rich in essential oils, the primary active component of which is limonene. Modern pharmacological research has revealed that limonene has many pharmacological effects, including antibacterial, anticancer, analgesic, immune regulation, neuroprotection, antioxidant, anti-inflammatory properties, and the treatment of metabolic diseases. It finds widespread application in a variety of industries, including cosmetics, food, personal care, medicine, pesticides, and others. This article reviews the pharmacological effects of limonene from citrus plants to build a scientific basis for future limonene research and application and also to lay the groundwork for developing functional foods for the prevention and management of linked disorders.

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“…Martins et al proved that LIPUS plus cryotherapy reduced oxidative stress in damaged muscle, leading to considerable tissue repair. More recently, limonene and diosmin were also demonstrated to be effective in reducing oxidative stress (Filho et al, 2018;Santos et al, 2020). Therefore, combining LIPUS with other chemical substances to expand its inherent therapeutic effect is a promising research direction.…”

Section: Skeletal Musclementioning

confidence: 99%

The therapeutic effects of low-intensity pulsed ultrasound in musculoskeletal soft tissue injuries: Focusing on the molecular mechanism

Qin

Luo

et al. 2022

Front. Bioeng. Biotechnol.

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Musculoskeletal soft tissue injuries are very common and usually occur during both sporting and everyday activities. The intervention of adjuvant therapies to promote tissue regeneration is of great importance to improving people’s quality of life and extending their productive lives. Though many studies have focused on the positive results and effectiveness of the LIPUS on soft tissue, the molecular mechanisms standing behind LIPUS effects are much less explored and reported, especially the intracellular signaling pathways. We incorporated all research on LIPUS in soft tissue diseases since 2005 and summarized studies that uncovered the intracellular molecular mechanism. This review will also provide the latest evidence-based research progress in this field and suggest research directions for future experiments.

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Topical application of (S)-(–)-limonene is as effective as phonophoresis for improving oxidative parameters of injured skeletal muscle in rats

Cited by 7 publications

References 28 publications

Association between Serum Monoterpene Levels, Hand Grip Strength, and Lean Muscle Mass in a Representative Sample of US Adults: NHANES 2013- 2014

Association between Serum Monoterpene Levels, Hand Grip Strength, and Lean Muscle Mass in a Representative Sample of US Adults: NHANES 2013- 2014

The Pharmacological Effects and Potential Applications of Limonene From Citrus Plants: A Review

The therapeutic effects of low-intensity pulsed ultrasound in musculoskeletal soft tissue injuries: Focusing on the molecular mechanism

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