Topical application of Otosporin® before in-office bleaching: a split mouth, triple-blind, multicenter randomized clinical trial

Favoreto, Michael Willian; Vochikovski, Laína; Terra, Renata Maria Oleniki; Campos, Veridiana Silva; Santos, Mariana Evangelista; Meireles, Sônia Saeger; Reis, Alessandra; Loguércio, Alessandro Dourado

doi:10.1007/s00784-021-04224-9

Cited by 9 publications

(16 citation statements)

References 59 publications

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“…Still, this effect was subtle and not clinically signi cant. Similarly, a recent RCT that evaluated the impact of the topical application of a corticoid-containing product did not nd any signi cant reduction in the risk and intensity of TS [13,20].…”

Section: Discussionmentioning

confidence: 87%

“…The CIEDE2000 system has been more recently employed, as it better estimates the visual perception of color [57]. The Whiteness Index provided more information on the direction of the bleaching effect [45] and has been added to recent RCTs about bleaching [20,46,50,58].…”

Section: Discussionmentioning

confidence: 99%

“…Participants had to record their pain intensity in the following time intervals: (1) during the treatment; (2) up to 1 h after each bleaching session; (3) between 1 and 24 h after each bleaching session; and (4) between 24 and 48 h. After both bleaching sessions, these measurements were performed using the vepoint numerical rating scale (NRS; 0 = none, 1 = mild, 2 = moderate, 3 = considerable, and 4 = severe) [41,42] and 0-10 visual analog scale (VAS) [20,25]. The VAS scale is a 10-cm horizontal line with scores of zero and 10 at their ends, in which zero means no sensitivity and 10 means severe tooth sensitivity.…”

Section: Evaluation Of Tooth Sensitivity (Ts)mentioning

confidence: 99%

“…The 16 shade guide tabs from the Vita Classical shade guide were arranged from the highest (B 1 ) to the lowest (C 4 ) value for the subjective examination. Although this scale is not linear in the truest sense, we treated the changes as representing a continuous and approximately linear ranking for analysis as already performed in published studies [20,23,25,41]. The Vita Bleachedguide 3D-MASTER contains lighter shade tabs and is organized from the highest (0M1) to the lowest (5M3) value.…”

Section: Color Changementioning

confidence: 99%

“…and corticosteroids [18][19][20] has previously been investigated, and they could not mitigate bleachinginduced TS [21]. So far, the most successful approach to reducing TS has been the topical application of desensitizers, such as those containing glutaraldehyde [22,23], potassium nitrate [24,25], and calcium agents [26,27].…”

Section: Introductionmentioning

confidence: 99%

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Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching - a double-blind, randomized controlled trial

Vochikovski

Favoreto

Rezende³

et al. 2022

Preprint

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Objectives: To evaluate the risk and intensity of tooth sensitivity (TS), and the efficacy of in-office bleaching after applying an experimental desensitizing gel composed of 10% calcium gluconate, 0.1% dexamethasone acetate, 10% potassium nitrate, and 5% glutaraldehyde.Material and Methods: In a split-mouth, double-blind, placebo-controlled study, 50 participants had their upper hemiarches randomized into experimental and placebo groups. Desensitizing and placebo gels were applied for 10 min before in-office bleaching (35% hydrogen peroxide, 1x50 min; two bleaching sessions; one-week interval). TS was recorded immediately after bleaching, 1, 24, and 48 h after each session, with a 0-10 visual analogue scale (VAS) and a five-point numerical rating scale (NRS). The color was recorded at baseline, one week after each session, and one month after the end of bleaching using shade guide units (ΔSGUs) and a spectrophotometer (ΔEab, ΔE00, and ΔWID). Results: Most participants (96%) felt some discomfort during treatment regardless of the study group. The odds ratio for pain was 0.65 (95% CI 0.1 to 4.1; p = 1.0). The intensity of TS did not differ between groups (p > 0.31), and it was only 0.34 VAS units lower in the experimental group. A significant color change occurred in all groups regardless of the group.Conclusions: The desensitizing experimental gel applied before in-office bleaching did not reduce the risk and the intensity of TS and did not affect color change.Clinical Relevance: Although the experimental desensitizing agent with varying mechanisms of action did not jeopardize the color change, it did not reduce the risk or intensity of in-office bleaching. Clinical Trial Registration Number: RBR-7T7D4D

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Evaluation Of Tooth Sensitivity (Ts)mentioning

confidence: 99%

Section: Color Changementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching - a double-blind, randomized controlled trial

Vochikovski

Favoreto

Rezende³

et al. 2022

Preprint

Self Cite

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Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching—a double-blind, randomized controlled trial

Vochikovski

Favoreto

Rezende³

et al. 2022

Clin Oral Invest

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Objectives To evaluate the risk and intensity of tooth sensitivity (TS), and the efficacy of in-office bleaching after applying an experimental desensitizing gel composed of 10% calcium gluconate, 0.1% dexamethasone acetate, 10% potassium nitrate, and 5% glutaraldehyde. Material and methods In a split-mouth, double-blind, placebo-controlled study, 50 participants had their upper hemiarches randomized into experimental and placebo groups. Desensitizing and placebo gels were applied for 10 min before in-office bleaching (35% hydrogen peroxide, 1 × 50 min; two bleaching sessions; 1-week interval). TS was recorded immediately after bleaching, 1, 24, and 48 h after each session, with a 0–10 visual analogue scale (VAS) and a five-point numerical rating scale (NRS). The color was recorded in all groups at baseline, 1 week after each session, and 1 month after the end of bleaching using shade guide units (ΔSGUs) and a spectrophotometer (Δ E ab , Δ E 00 , and ΔWI D ). Results Most participants (96%) felt some discomfort during treatment regardless of the study group. The odds ratio for pain was 0.65 (95% CI 0.1 to 4.1; p = 1.0). The intensity of TS did not differ between groups ( p > 0.31), and it was only 0.34 VAS units lower in the experimental group. A significant color change occurred in both groups regardless of the group. Conclusions The desensitizing experimental gel applied before in-office bleaching did not reduce the risk and the intensity of TS and did not affect color change. Clinical relevance Although the experimental desensitizing agent with varying mechanisms of action did not jeopardize the color change, it did not reduce the risk or intensity of in-office bleaching. Clinical trial registration number RBR-7T7D4D.

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Low and high hydrogen peroxide concentrations of in-office dental bleaching associated with violet light: an in vitro study

Vardasca,

Favoreto,

de Araujo Regis

et al. 2024

Clin Oral Invest

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Topical application of Otosporin® before in-office bleaching: a split mouth, triple-blind, multicenter randomized clinical trial

Cited by 9 publications

References 59 publications

Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching - a double-blind, randomized controlled trial

Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching - a double-blind, randomized controlled trial

Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching—a double-blind, randomized controlled trial

Low and high hydrogen peroxide concentrations of in-office dental bleaching associated with violet light: an in vitro study

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