Topical application of olive oil macerate of Momordica charantia L. promotes healing of excisional and incisional wounds in rat buccal mucosa

İlhan, Mert; Bolat, İsmail Eser; Süntar, İpek; Köklü, Harika Kutluay; Çankal, Dilek Aynur Uğar; Keleş, Hikmet; Akkol, Esra Küpeli

doi:10.1016/j.archoralbio.2015.09.006

Cited by 21 publications

(10 citation statements)

References 27 publications

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“…The observed antiinflammatory and healing effects of M. charantia may be attributed to hindering leukocyte infiltration and preventing edema as reported by other studies. [54][55][56] IL-6 produced in response to TNF and IL-1 is one of the crucial cytokines acting in the inflammatory response and cancer pathogenesis. [57,58] It is known that IL-6 and IL-1 released by active macrophages are increased in UC, CD and experimental colitis models.…”

Section: Discussionmentioning

confidence: 99%

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Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis

Semiz

Acar

Çetin

et al. 2020

Journal of Translational Internal Medicine

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Background and ObjectiveThis study was aimed to elucidate the molecular mechanism of Momordica charantia (MCh), along with a standard drug prednisolone, in a rat model of colitis induced by trinitrobenzene sulfonic acid (TNBS).MethodsAfter the induction of the experimental colitis, the animals were treated with MCh (4 g/kg/day) for 14 consecutive days by intragastric gavage. The colonic tissue expression levels of C-C motif chemokine ligand 17 (CCL-17), interleukin (IL)-1β, IL-6, IL-23, interferon-γ (IFN-γ), nuclear factor kappa B (NF-kB), and tumor necrosis factor-α (TNF-α), were determined at both mRNA and protein levels to estimate the effect of MCh. Besides, colonic specimens were analyzed histopathologically after staining with hematoxylin and eosin.ResultsThe body weights from TNBS-instigated colitis rats were found to be significantly lower than untreated animals. Also, the IFN-γ, IL-1β, IL-6, Il-23, TNF-α, CCL-17, and NF-kB mRNA and protein levels were increased significantly from 1.86-4.91-fold and 1.46-5.50-fold, respectively, in the TNBS-instigated colitis group as compared to the control. Both the MCh and prednisolone treatment significantly reduced the bodyweight loss. It also restored the induced colonic tissue levels of IL-1β, IL-6, IFN-γ, and TNF-α to normal levels seen in untreated animals. These results were also supported with the histochemical staining of the colonic tissues from both control and treated animals.ConclusionThe presented data strongly suggests that MCh has the anti-inflammatory effect that might be modulated through vitamin D metabolism. It is the right candidate for the treatment of UC as an alternative and complementary therapeutics.

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Section: Discussionmentioning

confidence: 99%

“…The observed anti-inflammatory and healing effects of M. charantia may be attributed to hindering leukocyte infiltration and preventing edema as reported by other studies. [ 54 , 55 , 56 ]…”

Section: Discussionmentioning

confidence: 99%

Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis

Semiz

Acar

Çetin

et al. 2020

Journal of Translational Internal Medicine

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“…Tannins are known to have antimicrobial, astringent, and protein coagulatory properties that aid in wound healing (Agyare et al, 2014;Nagarani et al, 2014;İlhan et al, 2015;Zhang et al, 2016;Jia et al 2017). Previous studies revealed the wound healing activity of bitter melon, and the promotion of wound healing through antiinflammatory and antibacterial effects and the stimulation of angiogenesis and fibroblast activity has been demonstrated in animal studies (Ilango et al, 2010; Prashanthi et al, 2012;Satar et al, 2013;Hussan et al, 2014;Pişkin et al, 2014;İlhan et al 2015;Singh et al 2017). Furthermore, in a different study, it was reported that bitter melon fruit extract-based PLA/Ag nanofibers used as wound healers can enhance the proliferation and function of epidermal cells and fibroblasts (Alippilakkotte et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…One of the most commonly known properties of bitter melon is its capacity for healing wounds. It has been reported that within the process of wound healing, the plant accelerates the production of growth factors, induces the proliferation of fibroblasts, and increases the oxygenation of the wound, an important factor in healing, by accelerating capillary circulation; it also accelerates the process of healing due to the antioxidant and antimicrobial effects of the phytochemical substances such as flavonoids and glycosides that it contains, and it positively affects the rate of wound healing, the ability of the wound to contract, the time for the wound to close, the epithelization process, and the tension of the wound (Teoh et al, 2009;Süntar et al, 2010;Prashanthi et al, 2012;Satar et al, 2013;Supraja and Usha, 2013;Pişkin et al, 2014;İlhan et al, 2015;Singh et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of bitter melon extract in the treatment of ischemic wounds in rats

Kısacık¹,

Güneş²,

Yaprakci³

et al. 2018

Turk J Biol

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There is no consensus on the properties of an ideal dressing for treating wounds. The aim of this study was to investigate the efficacy of dressings using topically administered bitter melon extract with olive oil, pure olive oil, nitrofurazone, and saline in the healing of ischemic wounds. A sample group of 48 rats was used in the trial. Their wounds were treated with bitter melon extract, pure olive oil, nitrofurazone, and saline. Data were collected between October 2014 and April 2015. The highest percentage (94.7%) of wound healing was observed in the bitter melon extract group and the lowest percentage (86.3%) in the nitrofurazone group. At the end of the 21st day, macroscopic reepithelialization was observed in 9 wounds in the bitter melon extract group (75%), in 6 wounds in the pure olive oil group (50%), and in only 3 wounds in the nitrofurazone and saline groups (25%). It can be concluded that dressing with a bitter melon extract is more efficient in the treatment of wounds than using nitrofurazone or saline, and that dressing with olive oil accelerates wound healing, although not as much as dressing with bitter melon extract.

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“…A significant response has been shown by powder ointment in terms of period of epithelization, wound-contracting ability and wound closure time. [171] Absolute ethanolic extract of bitter melon fruits and leaves are very effective in wound healing. Approximately, 1% w/v of the 95% absolute ethanol-50% benzene Momordica fruit extract considerably improved the rate of epithelization and wound closure.…”

Section: Antioxidant and Antiinflammatory Activitymentioning

confidence: 99%

Bitter melon (Momordica charantia): a natural healthy vegetable

Saeed

Afzaal

Niaz

et al. 2018

International Journal of Food Properties

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Bitter melon provides health benefits against various ailments for improving the quality of life. It is nutrient dense plant-based food containing versatility of bioactive compounds such as alkaloids, polypeptide, vitamins, and minerals. Owing to presence of bioactive compounds, it has the ability to fight against various lifestyle related disorders, e.g. cancer insurgence, diabetes mellitus, abdominal pain, kidney (stone), fever, and scabies. Amongst bioactive moieties, p-insulin is similar to insulin whose subcutaneous injection significantly lower blood glucose levels in diabetic patients. It also contains steroidal saponins called charantin, act alike peptides and certain alkaloids that effectively control sugar level in blood. The therapeutic perspectives have been also highlighted as they are helpful in regulating blood cholesterol thus protecting the body from cardiovascular disorders like atherosclerosis. Whole fruit, seeds and leaves of bitter melon regulates impaired antioxidant status and suppress fat accumulation. Moreover, curative potential of its bioactive components and their utilization in value added food products are also the limelight of article.

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Topical application of olive oil macerate of Momordica charantia L. promotes healing of excisional and incisional wounds in rat buccal mucosa

Cited by 21 publications

References 27 publications

Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis

Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis

Effectiveness of bitter melon extract in the treatment of ischemic wounds in rats

Bitter melon (Momordica charantia): a natural healthy vegetable

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