Topical application of Kochia scoparia inhibits the development of contact dermatitis in mice

Choi, You Yeon; Kim, Mi Hye; Lee, Ji Ye; Ji, Hong; Kim, Sung Hoon; Yang, Woong Mο

doi:10.1016/j.jep.2014.04.009

Cited by 31 publications

(34 citation statements)

References 33 publications

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“…In addition, IFN-γ is indicative of type 1 T helper skewing reaction of T cells and rapidly promotes the secretion of mediators, including chemokine (C-X-C motif) receptor 3 agonist and MCP-1, when it is present alone or together with TNF-α (13,14). The results of the present study are consistent with those of a previous study by Choi et al (12), who demonstrated that topical application of K. scoparia extract inhibited the expression of IL-1β and TNF-α messenger RNA. In the present study, the production of TNF-α, IFN-γ, MCP-1 and IL-10 was evaluated using proteins obtained from samples of lysed tissues.…”

Section: Discussionsupporting

confidence: 92%

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Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice

Ryu

Han

et al. 2015

Molecular Medicine Reports

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Abstract. The mature fruit of Kochia scoparia (L.) Schrad. is widely administered in China and Korea as a medicinal herb for treatment of skin diseases, diabetes mellitus and rheumatoid arthritis. The present study investigated the effects of methanol extracts of K. scoparia dried fruit (MEKS) on ear swelling, histopathological changes (such as epidermal acanthosis, spongiosis and immune cell infiltration) and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mice. Topical application of MEKS inhibited DNFB-induced ear thickness and weight increases, as well as DNFB-induced epidermal acanthosis, spongiosis and immune cell infiltration. In addition, treatment with MEKS significantly decreased the levels of tumor necrosis factor-α, interferon-γ and monocyte chemotactic protein-1 in inflamed tissues. These data indicate that the mature fruit of K. scoparia has the potential to be administered for the treatment of inflammatory skin diseases and that the anti-inflammatory action of K. scoparia is involved in the inhibition of type 1 T helper cell skewing reactions.

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Section: Discussionsupporting

confidence: 92%

“…Previous studies have indicated that K. scoparia and its components exert anti-inflammatory (9) and anti-allergic (10,11) activities. Choi et al (12) recently reported that the water extract of K. scoparia inhibits the development of CD in mice.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice

Ryu

Han

et al. 2015

Molecular Medicine Reports

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“…has been used to clear heat and dry dampness. It was reported to ameliorate dermatitis via inhibition of the production of proinflammatory cytokines [50]. Sheng-di-huang (Radix Rehmanniae; Rehmannia glutinosa (Gaertn.)…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study

Weng

Chen²,

Wang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Traditional Chinese medicine (TCM) has long been used for patients with psoriasis. This study aimed to investigate TCM usage in patients with psoriasis. We analyzed a cohort of one million individuals representing the 23 million enrollees randomly selected from the National Health Insurance Research Database in Taiwan. We identified 28,510 patients newly diagnosed with psoriasis between 2000 and 2010. Among them, 20,084 (70.4%) patients were TCM users. Patients who were female, younger, white-collar workers and lived in urbanized area tended to be TCM users. The median interval between the initial diagnosis of psoriasis to the first TCM consultation was 12 months. More than half (N = 11,609; 57.8%) of the TCM users received only Chinese herbal medicine. Win-qing-yin and Bai-xian-pi were the most commonly prescribed Chinese herbal formula and single herb, respectively. The core prescription pattern comprised Mu-dan-pi, Wen-qing-yin, Zi-cao, Bai-xian-pi, and Di-fu-zi. Patients preferred TCM than Western medicine consultations when they had metabolic syndrome, hepatitis, rheumatoid arthritis, alopecia areata, Crohn's disease, cancer, depression, fatty liver, chronic airway obstruction, sleep disorder, and allergic rhinitis. In conclusion, TCM use is popular among patients with psoriasis in Taiwan. Future clinical trials to investigate its efficacy are warranted.

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“…[ 9 ] Among these compounds, triterpenoid saponin and momordin Ic have been reported as the main constituents. Many investigations reported that K. scoparia has a variety of biological efficacies against cancer,[ 10 ] contact dermatitis,[ 11 ] asthma,[ 12 ] and rheumatoid arthritis[ 7 ] in vitro or in vivo . Phytochemicals from K. scoparia also have shown to have various biological activities.…”

Section: Introductionmentioning

confidence: 99%

Quantification analysis and In vitro anti-inflammatory effects of 20-hydroxyecdysone, momordin ic, and oleanolic acid from the fructus of Kochia scoparia

et al. 2017

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Background:The fructus of Kochia scoparia Schrader (Chenopodiaceae) is a traditional herbal medicine that has been used for treating gonorrhea and dermatitis.Objective:We investigated the anti-inflammatory activities of three marker compounds, including 20-hydroxyecdysone, momordin Ic, and oleanolic acid, from the fructus of K. scoparia.Materials and Methods:The simultaneous analysis of three components was performed using high-performance liquid chromatography and high-performance thin-layer chromatography. We evaluated the anti-inflammatory effects of the nine marker compounds by determining their anti-inflammatory activities in the murine macrophage cell line RAW 264.7.Results:Among three marker compounds, momordin Ic, but not 20-hydroxyecdysone and oleanolic acid, had inhibitory effects on the production of inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in LPS-treated RAW264.7 macrophages. The effects of three marker compounds on prostaglandin E2(PGE2) were also evaluated. All three compounds significantly reduced PGE2 production in LPS-treated cells.Conclusions:We suggest that momordin Ic is the most potent phytochemical of the fructus of K. scoparia as an anti-inflammatory agent.SUMMARY Simultaneous analysis of three phenylpropanoids in the Kochia scoparia was established using HPLC-PDA systemThe momordin Ic had inhibitory effects on production of inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in LPS-treated RAW264.7 macrophagesThe momordin Ic, 20-hydroxyecdysone, and oleanolic acid significantly reduced PGE2 production in LPS-treated cells. Abbreviations used: HPLC: High-performance liquid chromatography; TNF-α: Tumor necrosis factor alpha; IL-6: Interleukin-6; PGE2: Pro-inflammatory mediator prostaglandin E2; LPS: Lipopolysaccharide.

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Topical application of Kochia scoparia inhibits the development of contact dermatitis in mice

Cited by 31 publications

References 33 publications

Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice

Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice

Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study

Quantification analysis and In vitro anti-inflammatory effects of 20-hydroxyecdysone, momordin ic, and oleanolic acid from the fructus of Kochia scoparia

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