Topical Application of Insulin in the Diabetic Wound Ulcer of Foot and Its Comparison With Regular Normal Saline Dressing

Abstract

BACKGROUND Diabetic foot ulcers are inevitable in 15% of diabetic patients even if they follow the diet or control blood sugar level meticulously. The mainstay of treatment for diabetes related foot ulceration is a multidisciplinary team (MDT) approach that includes metabolic control, debridement, offloading/pressure redistribution, vascular control, infection control and seamless integrated wound care. And the ulcer usually is of a chronic type. With regard to topical agents, the effectiveness of topical Insulin is considered valid and effective on wound healing process. The present study is to compare the efficacy of Topical Insulin vs. Normal Saline dressing. MATERIALS AND METHODS This is a non-randomised control study. A total of sixty patients with Diabetic foot ulcer were enrolled and the study was done in

Effectiveness of Topical Insulin Dressings in Management of Diabetic Foot Ulcers

“…Praveen et al [22] showed the ulcer size on Day 1 was 48.33 ± 11.35 mm and 47.30 ± 11.30 mm in insulin group and saline group, respectively, and the complete healing time achieved in insulin versus saline group was 30.63 ± 6.5 days and 60.47 ± 23.31 days, respectively, with significant p value <0.0001.…”

“…There was a statistical difference in the initial length and breadth of the wound size among both the groups. However, final length and breadth decreased significantly in both groups, retaining the insulin group with statistically significant reduction compared to normal saline group (mean ± SD; final length: normal saline vs. insulin 47.30 ± 11.3 vs. 48.33 ± 11.35; P = 0.725, final breadth: 36.47 ± 10.94 vs. 37.4 ± 7.5; P = 0.701) [22].…”