Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter

Song, Su Jeong; Hyun, Soo‐Wang; Lee, Tae Gu; Park, Bong‐Kyun; Jo, Kyuhyung; Lee, Ik Soo; Kim, Chan-Sik

doi:10.1155/2019/1429548

Cited by 11 publications

(7 citation statements)

References 45 publications

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“…Each AVP scan was composed of five segments: orbital optic nerve, intracanalicular optic nerve, intracranial optic nerve, optic chiasm and optic tract. 12 ( Figure 1) Treatment outcomes, including time from initial ocular symptoms (pain and/or visual loss) to IVMP administration, and BCVA at recovery were also analysed.…”

Section: Methodsmentioning

confidence: 99%

Prognostic Factors for Visual Outcomes Following the First Episode of NMOSD-Related Optic Neuritis in Affected Eyes

Thongmee¹,

Padungkiatsagul²,

Jindahra³

et al. 2020

OPTH

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Objective: We aim to identify prognostic factors for visual outcomes following a first episode of neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON) in affected eyes. Materials and Methods: This was a single-center, retrospective study. The study included 50 individuals who were diagnosed with NMOSD-ON (63 affected eyes) in a tertiary institution over a 12-year period. Data regarding any second, or higher, episodes of NMOSD-ON in each eye were not taken into consideration. Medical records of included individuals were reviewed. Demographic data, clinical and magnetic resonance imaging characteristics, and treatment outcomes were collected. Main outcome measures of the study were prognostic factors for good visual outcome (best-corrected visual acuity (BCVA) ≥ 20/200) following an initial episode of NMOSD-ON in affected eyes. Results: Sixty-three affected eyes of 50 individuals (3 men and 47 women) were included. BCVA at nadir that was better than counting fingers (CF) (odds ratio 10.43, 95% confidence interval 1.04, 104.45, p = 0.046) and time from NMOSD-ON onset to intravenous methylprednisolone (IVMP), less than 21 days (odds ratio 10.73, 95% confidence interval 1.91, 60.01, p = 0.007), were significantly associated with good visual outcomes. Conclusion: BCVA at nadir that was better than CF and treatment with IVMP within 21 days of symptom onset were important prognostic factors of good visual outcomes following a first episode of NMOSD-ON in affected eyes.

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Section: Methodsmentioning

confidence: 99%

Prognostic Factors for Visual Outcomes Following the First Episode of NMOSD-Related Optic Neuritis in Affected Eyes

Thongmee¹,

Padungkiatsagul²,

Jindahra³

et al. 2020

OPTH

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“…Numerous reports demonstrated that women are disproportionately affected by DED, are diagnosed at a younger age, and experience more severe symptoms compared with men [69,70]. Similar to the human studies, several animal studies suggested female sex is a risk factor for DED [5,71,72]. McClellan et al [71] reported that female C57BL/6 mice developed greater corneal barrier disruption than age-matched male mice did, although other features of DED such as low goblet cell density and LG infiltration were similar in both sexes.…”

Section: Discussionmentioning

confidence: 81%

“…McClellan et al [ 71 ] reported that female C57BL/6 mice developed greater corneal barrier disruption than age-matched male mice did, although other features of DED such as low goblet cell density and LG infiltration were similar in both sexes. Recently, Song et al [ 72 ] used six-week-old female SD rats to assess the effect of natural products on a PM 2.5 -induced DED model. Yang et al [ 5 ] also used 6–8-week-old female C57BL/6 mice to evaluated the harmful effect of PM 2.5 on the eye.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Oral Application of Corni Fructus on the Disorders of the Cornea, Conjunctiva, Lacrimal Gland and Retina by Topical Particulate Matter 2.5

Lee

Kim

et al. 2021

Nutrients

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Particulate matter 2.5 (PM2.5) may aggravate dry eye disease (DED). Corni Fructus (CF), which is fruit of Cornus officinalis Sieb. et Zucc., has been reported to have various beneficial pharmacological effects, whereas the effect of CF on the eye is still unknown. Therefore, in this study, we investigated the effect of oral administration of water extract of CF (CFW) on the eye, hematology, and biochemistry in a DED model induced by topical exposure to PM2.5. Furthermore, the efficacy of CFW compared with cyclosporine (CsA), an anti-inflammatory agent, and lutein, the posterior eye-protective agent. Sprague-Dawley rats were topically administered 5 mg/mL PM2.5 in both eyes four times daily for 14 days. During the same period, CFW (200 mg/kg and 400 mg/kg) and lutein (4.1 mg/kg) were orally administered once a day. All eyes of rats in the 0.05% cyclosporine A (CsA)-treated group were topically exposed to 20 μL of CsA, twice daily for 14 days. Oral administration of CFW attenuated the PM2.5-induced reduction of tear secretion and corneal epithelial damage. In addition, CFW protected against goblet cell loss in conjunctiva and overexpression of inflammatory factors in the lacrimal gland following topical exposure to PM2.5. Furthermore, CFW markedly prevented PM2.5-induced ganglion cell loss and recovered the thickness of inner plexiform layer. Meanwhile, CFW treatment decreased the levels of total cholesterol and low-density lipoprotein cholesterol in serum induced by PM2.5. Importantly, the efficacy of CFW was superior or similar to that of CsA and lutein. Taken together, oral administration of CFW may have protective effects against PM2.5-induced DED symptoms via stabilization of the tear film and suppression of inflammation. Furthermore, CFW may in part contribute to improving retinal function and lipid metabolism disorder.

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“…One study revealed that L. platyphylla can protect against ocular damage induced by particulate matter exposure. Topical L. platyphylla extract applied in rats with DED induced by urban particulate matter increased tear volume, decreased corneal epithelial cell injury and apoptosis, restored the corneal mucin-4 layer, and maintained the conjunctival goblet cell density [ 37 ].…”

Section: Urrent Research On Traditional Chinese Medicine In the Treatment Of Dry Eye Diseasementioning

confidence: 99%

Retrospective evaluation of the curative effect of traditional Chinese medicine on dry eye disease

Yang

2021

Tzu Chi Medical Journal

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Dry eye disease (DED) is a multifactorial illness with an increasingly high global prevalence and multiple risk factors that widely influences patients’ daily lives. It is essential to identify treatments with few or no side effects for patients with DED. We have reviewed studies published from 2001 to 2020 that investigated traditional Chinese medicine (TCM) and integrated Chinese and Western medicine for DED treatment. Current Chinese medicines used in DED therapy were categorized into four types, namely anti-oxidants, anti-inflammatory agents, hormone-like agents, and cell-repairing agents. Compound herbs, including Chi-Ju-Di-Huang-Wan and Qiming granule, can effectively alleviate dry eye symptoms. Moreover, patients with DED who were treated with Western medicine combined with TCM experienced significantly magnified therapeutic effects and reasonable costs of treatment. In conclusion, TCM can be a promising approach for treating DED, and combined treatment with TCM and Western drugs may represent a new strategy for improving the curative effect.

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Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter

Cited by 11 publications

References 45 publications

<p>Prognostic Factors for Visual Outcomes Following the First Episode of NMOSD-Related Optic Neuritis in Affected Eyes</p>

<p>Prognostic Factors for Visual Outcomes Following the First Episode of NMOSD-Related Optic Neuritis in Affected Eyes</p>

The Protective Effect of Oral Application of Corni Fructus on the Disorders of the Cornea, Conjunctiva, Lacrimal Gland and Retina by Topical Particulate Matter 2.5

Retrospective evaluation of the curative effect of traditional Chinese medicine on dry eye disease

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