Topical Application of Dieckol Ameliorates Atopic Dermatitis in NC/Nga Mice by Suppressing Thymic Stromal Lymphopoietin Production

Yang, Gabsik; Oh, Jee Woo; Lee, Hye Eun E.; Lim, Kyung Min; Lee, Joo Young

doi:10.1016/j.jid.2015.12.046

Cited by 16 publications

(10 citation statements)

References 14 publications

(13 reference statements)

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“…The in vivo antiallergic effect of the isolated dieckol was demonstrated in that percutaneous and oral dieckol administration suppressed ear swelling induced by three sensitizers in mice (Table 2), which corroborates other reports. Dieckol was reported to alleviate passive cutaneous anaphylactic reactions and atopic dermatitis in NC/Nga mice (Ahn et al, 2015;Yang et al, 2016), and supporting literature confirms the in vivo effects observed in the present study.…”

Section: Discussionsupporting

confidence: 91%

Dieckol isolated from a brown alga,Eisenia nipponica, suppresses ear swelling from allergic inflammation in mouse

et al. 2021

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In developed countries, the incidence of allergies such as food allergy, asthma, atopic dermatitis, and hay fever has increase, becoming an acute problem (Platts-Mills, 2015). According to the Japanese Ministry of Health, Labor, and Welfare, half of the Japanese people may suffer from allergies, making them a societal problem (Taniguchi, 2012). Natural remedies and foods possessing antiallergic and anti-inflammatory effects are highly sought-after and recently researchers have endeavored to identify natural compounds and products with antiallergic properties.Prebiotics and probiotics, such as dietary fibers (e.g., oligosaccharides) and lactic acid bacteria, are known to exert antiallergic effects through gut-based immunomodulation (Hardy et al., 2013).Phenolic compounds (polyphenols) are another well-known group of natural antiallergic compounds derived from food products. For

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Section: Discussionsupporting

confidence: 91%

Dieckol isolated from a brown alga,Eisenia nipponica, suppresses ear swelling from allergic inflammation in mouse

et al. 2021

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“…Bone marrow-derived primary macrophages (BMDMs) were prepared after bone marrow was isolated from C57BL/6 mice as described previously [18]. Cell culture was performed as previously described [19]. Briefly, BMDMs were cultured in Dulbecco’s modified eagle medium (DMEM) containing 10% ( v / v ) fetal bovine serum (Invitrogen, Carlsbad, CA, USA), 10,000 units/mL of penicillin, and 10,000 μg/mL of streptomycin (Invitrogen).…”

Section: Methodsmentioning

confidence: 99%

Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis

et al. 2019

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Gout is a chronic inflammatory disease evoked by the deposition of monosodium urate (MSU) crystals in joint tissues. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is responsible for the gout inflammatory symptoms induced by MSU crystals. We investigated whether epigallocatechin-3-gallate (EGCG) suppresses the activation of the NLRP3 inflammasome, thereby effectively preventing gouty inflammation. EGCG blocked MSU crystal-induced production of caspase-1(p10) and interleukin-1β in primary mouse macrophages, indicating its suppressive effect on the NLRP3 inflammasome. In an acute gout mouse model, oral administration of EGCG to mice effectively alleviated gout inflammatory symptoms in mouse foot tissue injected with MSU crystals. The in vivo suppressive effects of EGCG correlated well with the suppression of the NLRP3 inflammasome in mouse foot tissue. EGCG inhibited the de novo synthesis of mitochondrial DNA as well as the production of reactive oxygen species in primary mouse macrophages, contributing to the suppression of the NLRP3 inflammasome. These results show that EGCG suppresses the activation of the NLRP3 inflammasome in macrophages via the blockade of mitochondrial DNA synthesis, contributing to the prevention of gouty inflammation. The inhibitory effects of EGCG on the NLRP3 inflammasome make EGCG a promising therapeutic option for NLRP3-dependent diseases such as gout.

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“…Therefore, the modulation of TSLP expression may be an effective strategy to prevent atopic dermatitis symptoms, balancing Th1 and Th2 immune responses. Our previous study showed that dieckol, a phlorotannin isolated from Ecklonia cava , suppressed TSLP production in mouse skin, reduced Th2-type immunity, and alleviated atopic dermatitis-like symptoms in the NC/Nga mouse model of AD ( Yang et al ., 2016b ). In this study topical application of Phloxine O, a cosmetic colorant, inhibited TSLP production and downregulated Th2 cytokines, such as IL-4, IL-5 and IL-13, resulting in decreased IgE and histamine levels.…”

Section: Discussionmentioning

confidence: 99%

Phloxine O, a Cosmetic Colorant, Suppresses the Expression of Thymic Stromal Lymphopoietin and Acute Dermatitis Symptoms in Mice

Lee

Yang

Kim

et al. 2018

Biomol Ther (Seoul)

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Cosmetics are primarily applied to the skin; therefore, the association of cosmetic dyes with skin diseases or inflammation is a topic of great interest. Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine that activates dendritic cells to promote Th2 inflammatory immune responses. TSLP is highly expressed in keratinocytes under inflammatory conditions, which suggests that it may play a critical role in the development of skin diseases, such as atopic dermatitis. Therefore, we investigated whether cosmetic dyes influenced the production of TSLP by keratinocytes. Phloxine O, also known as D&C Red No.27, is one of the most common red synthetic pigments and is widely used in colored cosmetics. Our results showed that Phloxine O downregulated phorbol 12-myristate 13-acetate-induced production of TSLP in a murine keratinocyte cell line (PAM212). Phloxine O also suppressed TSLP expression in KCMH-1 cells, which are mouse keratinocytes that constitutively produce high levels of TSLP. To investigate the in vivo effects of Phloxine O, we induced TSLP expression in mouse ear skin by topically applying MC903, a vitamin D3 analogue that is a well-known inducer of atopic dermatitis-like symptoms. Topical application of Phloxine O prevented MC903-induced TSLP production in mouse ear skin, attenuated the acute dermatitis-like symptoms and decreased serum IgE and histamine levels in mice. Suppression of TSLP expression by Phloxine O correlated with reduced expression of OX40 ligand and Th2 cytokines in mouse ear skin. Our results showed that Phloxine O may be beneficial to prevent dermatitis by suppressing the expression of TSLP and Th2 cytokines in skin.

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Topical Application of Dieckol Ameliorates Atopic Dermatitis in NC/Nga Mice by Suppressing Thymic Stromal Lymphopoietin Production

Abstract: We also thank the NHLBI GO Exome Sequencing Project (see http://evs.gs.washington.edu/EVS/) and its ongoing studies that produced and provided exome variant calls for comparison: the Lung GO

Cited by 16 publications

References 14 publications

Dieckol isolated from a brown alga,Eisenia nipponica, suppresses ear swelling from allergic inflammation in mouse

Dieckol isolated from a brown alga,Eisenia nipponica, suppresses ear swelling from allergic inflammation in mouse

Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis

Phloxine O, a Cosmetic Colorant, Suppresses the Expression of Thymic Stromal Lymphopoietin and Acute Dermatitis Symptoms in Mice

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