Topical Antiseptics in Minimizing Ocular Surface Bacterial Load Before Ophthalmic Surgery: A Randomized Controlled Trial

Romano, Vito; Ferrara, Mariantonia; Gatti, Francesca; Airaldi, Matteo; Borroni, Davide; Aragona, Emanuela; Rocha-de-Lossada, Carlos; Gabrielli, Federico; Papa, Filomena Tiziana; Romano, Mario R.; Calza, Stefano; Semeraro, Francesco

doi:10.1016/j.ajo.2024.01.007

Cited by 1 publication

(1 citation statement)

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“…Additionally, a randomized controlled trial comparing PI 0.6% with CHX 0.02% chlorhexidine demonstrated that CHX 0.02% significantly reduced the bacterial load on the ocular surface more effectively than PI 0.6%, without significant alterations in the taxonomic composition. CHX was also found to be better tolerated than PI [31]. There is no evidence for the superior effectiveness of PI vs. CHX and the best way to avoid endophthalmitis post-surgery has not been determined [32,33].…”

Section: Discussionmentioning

confidence: 98%

Comparing the in vitro efficacy of chlorhexidine and povidone-iodine in the prevention of post-surgical endophthalmitis

Batista,

Loscos-Giménez,

Gámez

et al. 2024

J Ophthal Inflamm Infect

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Background Intravitreal injections are a common ophthalmologic procedure. While infections following these injections are rare, they can lead to endophthalmitis, with potentially serious consequences. Various methods have been proposed to prevent endophthalmitis, including the use of antisepsis and antibiotics in patient preparation. Purpose To evaluate the antiseptic efficacy of aqueous chlorhexidine (CHX) and povidone-iodine (PI) when used alone and in combination with lidocaine gel (LG) in vitro. Methods Two independent experimental trials were conducted. The first trial determined the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of CHX and PI against six bacterial strains. The second trial evaluated the bactericidal efficacy of the antiseptic agents (CHX 0.1% and PI 5%) and their combination with LG against the same bacterial strains. Results CHX was more effective than PI in reducing the number of colonies forming units (cfus) of the tested bacteria. The order in which the antiseptic and LG were administered affected their effectiveness, with CHX administered before LG resulting in greater reduction of bacterial growth. Conclusions CHX 0.1% is more effective than PI 5% as an antiseptic agent. Application of CHX and PI prior to the use of lidocaine gel results in a more effective reduction of microorganisms.

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Section: Discussionmentioning

confidence: 98%