Topical antimicrobial prescribing patterns in residents of Australian aged-care facilities: use of a national point prevalence survey to identify opportunities for quality improvement

Bennett, Noleen; Walker, Katherine; Buising, Kirsty; Cheah, Ron; Fang, Xin; Ingram, Robyn; James, Rodney; Malloy, Michael J.; Thursky, Karin; Worth, Leon J.

doi:10.1016/j.ajic.2021.03.019

Cited by 1 publication

(4 citation statements)

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“…7,8 In an Australian study with residents of aged care facilities, TAFs were the most common prescribed topical antimicrobials, with clotrimazole (83.5%) and miconazole (9.1%) being the most frequent choices. 8 The authors reported that TAFs were commonly prescribed Total, n (%)…”

Section: Discussionmentioning

confidence: 99%

“…for as-needed administration (38.8%) and for periods greater than 6 months (11.3%). 8 These prolonged and, sometimes, unnecessary administration may predispose to sensitization to TAFs. In fact, the frequency of positive patch tests reactions to TAFs is strongly influenced by local prescribing habits, availability in the country, and also by the drug concentration on topical formulations.…”

Section: Discussionmentioning

confidence: 99%

“…According to the Global Burden of Disease report, fungal skin infections are ranked as the fifth skin disease with the highest years lived with disability score 6 . TAFs constitute a commonly prescribed topical therapy 7,8 . In an Australian study with residents of aged care facilities, TAFs were the most common prescribed topical antimicrobials, with clotrimazole (83.5%) and miconazole (9.1%) being the most frequent choices 8 .…”

Section: Discussionmentioning

confidence: 99%

“…TAFs constitute a commonly prescribed topical therapy 7,8 . In an Australian study with residents of aged care facilities, TAFs were the most common prescribed topical antimicrobials, with clotrimazole (83.5%) and miconazole (9.1%) being the most frequent choices 8 . The authors reported that TAFs were commonly prescribed for as‐needed administration (38.8%) and for periods greater than 6 months (11.3%) 8 .…”

Section: Discussionmentioning

confidence: 99%

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Contact allergy to antifungals: Results of a 12‐year retrospective study

et al. 2022

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Background Contact allergy has been reported as a side effect of topical antifungals (TAFs), although most evidence has come from small case series. Objective To investigate the frequency and associated factors of contact allergy to TAFs. Methods We performed a retrospective analysis of the data of the Contact Allergy Unit of a University Dermatology Department between January 2009 and April 2021. From a cohort of 3788 patients tested in our unit, aimed testing was performed in 482 patients using TAFs from Chemotechnique Diagnostics (Vellinge, Sweden), allergEAZE, and, in some cases, commercial preparations ‘as is’. Results Contact allergy to antifungals was found in 27 patients (0.71% of consecutively tested patients and 5.6% of those who had aimed testing). Foot and leg eczema were the clinical presentation in 12 (44.4%) and 10 (37.0%) patients, respectively. Positive reactions were observed mostly with econazole nitrate 1% alcohol (51.9%), miconazole 1% alcohol (48.9%), tioconazole 28% solution (40.7%), and clotrimazole 5% pet. (18.5%). Fifteen patients (55.6%) had sensitization to more than one antifungal. Conclusions Contact allergy to antifungals was uncommon and occurred mostly associated with foot dermatitis. Most patients were sensitized to more than one chemical, particularly to azoles, which may limit future choices of TAF treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%