Topical Antifungal Agents

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

“…These substances resemble allylamines in terms of their structures and modes of action, but they are benzylamine derivatives . Similar to allylamines, butenafine functions through the inhibition of squalene epoxidase, resulting in reduced ergosterol production, heightened accumulation of the sterol precursor squalene, and consequent perturbation of the fungal cell membrane . Dermatophytosis in the immediate area is treated with 1% of the topical cream formulation …”

A Review of Biologically Active Oxime Ethers

“…Rossello et al [7] studied oxime ethers of imidazole derivatives ( 5) and (6) (Figure 2), which differed in the distribution of substituents around the C=N-O group compared to oxiconazole (1). They were evaluated in terms of antifungal properties, e.g., against the most important human pathogens-Candida albicans and Aspergillus fumigatus, as well as Candida glabrata, Candida krusei and Aspergillus flavus.…”

“…It is an acetophenone-oxime derivative of the basic imidazole structural unit (substituted heterocyclic ring with a nitrogen in the 3-position). It is applied to the skin in the form of an ointment, cream or powder [1]. Fluvoxamine (2) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.…”

Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook

“…Selenium sulfide decreases the differentiation of epidermal cells and minimizes corneocyte production by slowing the production and development of keratinocytes. 23 Selenium was first approved for medical use in the United States in 1951. 24 It is included on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.…”