Topical antibiotics for chronic suppurative otitis media

Brennan‐Jones, Christopher G.; Head, Karen; Chong, Lee Yee; Burton, Martin J; Schilder, Anne G. M.; Bhutta, Mahmood F.

doi:10.1002/14651858.cd013051.pub2

Cited by 33 publications

(40 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since drug-loaded slabs F6-0.5 and H6-0.5 demonstrated to be highly efficient against both Gram-negative and Gram-positive bacteria, only F6-0.5 and H6-0.5 were chosen for a detailed monitoring of the drug release profiles to avoid waste of drug and concerns on toxicity. This information should allow the prediction for how long the hearing aids could continue delivering the drugs, keeping in mind that otitis requires one or two weeks pharmacological treatment [42]. Ciprofloxacin hydrochloride is a hydrophilic antimicrobial agent (solubility 170 µg/mL in PBS; log P -0.94) [70], while fluocinolone acetonide is a relatively hydrophobic corticosteroid (solubility 17 µg/mL in PBS; log P 2.24) [71].…”

Section: Drug Release Studiesmentioning

confidence: 99%

“…In the case of ear infections, topical antibiotics are better than aural toilet (ear cleaning using dry mopping or irrigation) alone, and systemic or topical fluoroquinolones (e.g. ciprofloxacin, ofloxacin) are more effective than other types of antibiotics [42,43]. It has also been reported that the use of ciprofloxacin in combination with fluocinolone acetonide is more effective than treatment with each drug individually for acute otitis media with tympanostomy tubes (AOMT) in children and is safe and well tolerated [44,45].…”

Section: Introductionmentioning

confidence: 99%

“…children and is safe and well tolerated [42,43] controlled drug release were evaluated. Moreover, the efficacy of a 3D printed device to avoid the biofilm formation was evaluated against Pseudomonas aeruginosa (Gramnegative) and Staphylococcus aureus (Gram-positive), two avid biofilm formers involved in chronic ear infections [50,51].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Anti-biofilm multi drug-loaded 3D printed hearing aids

Vivero-Lopez

Muras

et al. 2021

Materials Science and Engineering: C

View full text Add to dashboard Cite

Over 5% of the world's population has disabling hearing loss, which affects approximately one third of individuals over 65 years. Hearing aids are commonly used in this population group, but prolonged use of these devices may cause ear infections. We describe for the first time, the use of 3D printing to fabricate hearing aids loaded with two antibiotics, ciprofloxacin and fluocinolone acetonide. Digital light processing 3D printing was employed to manufacture hearing aids from two polymer resins, ENG hard and Flexible. The inclusion of the antibiotics did not affect the mechanical properties of the hearing aids. All multi-drug-loaded devices exhibited a hydrophilic surface, excellent blood compatibility and anti-biofilm activity against P. aeruginosa and S. aureus. Hearing aids loaded with ciprofloxacin (6%w/w) and fluocinolone acetonide (0.5% w/w) sustained drug release for more than two weeks and inhibited biofilm formation on the surface of the devices and bacteria growth in the surrounding medium. In summary, this work highlights the potential of vat photopolymerization 3D printing as a versatile manufacturing approach to fabricate high-fidelity patient-specific medical devices with anti-bacterial properties.

show abstract

Section: Drug Release Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-biofilm multi drug-loaded 3D printed hearing aids

Vivero-Lopez

Muras

et al. 2021

Materials Science and Engineering: C

View full text Add to dashboard Cite

show abstract

“…34 When otorrhea persists for 2 weeks or longer with a nonintact tympanic membrane (tube or perforation), additional topical antibiotics, with or without concurrent oral antibiotic, appear effective, but the quality and consistency of supporting evidence is low. 37 Expert insight and opinion. Effective management of recurrent or persistent TTO begins with identifying the likely cause, based on the laterality and temporal pattern ( Table 5).…”

Section: What Is the Best Way To Manage A Child With Recurrent Or Permentioning

confidence: 99%

Tympanostomy Tube Controversies and Issues: State-of-the-Art Review

Rosenfeld

2020

Ear Nose Throat J

View full text Add to dashboard Cite

Objective: To review current pragmatic issues and controversies related to tympanostomy tubes in children, in the context of current best research evidence plus expert opinion to provide nuance, address uncertainties, and fill evidence gaps. Methods: Each issue or controversy is followed by the relevant current best evidence, expert insight and opinion, and recommendations for action. The role of expert opinion and experience in forming conclusions is inversely related to the quality, consistency, and adequacy of published evidence. Conclusions are combined with opportunities for shared decision-making with caregivers to recommend pragmatic actions for clinicians in everyday settings. Results: The issues and controversies discussed include (1) appropriate tube indications, (2) rationale for not recommending tubes for recurrent acute otitis media without persistent middle ear effusion, (3) role of tubes in at-risk children with otitis media with effusion, (4) role of new, automated tube insertion devices, (5) appropriateness and feasibility of in-office tube insertion in awake children, (6) managing methicillin-resistant Staphylococcus aureus acute tube otorrhea, and (7) managing recurrent or persistent tube otorrhea. Conclusions: Despite a substantial, and constantly growing, volume of high-level evidence on managing children with tympanostomy tubes, there will always be gaps, uncertainties, and controversies that benefit from clinician experience and expert opinion. In that regard, the issues discussed in this review article will hopefully aid clinicians in everyday, pragmatic management decisions.

show abstract

“…[19] mencionan que la administración de ciprofloxacino por vía oral asociado a la administración por vía tópica no aportó beneficio alguno frente a las vías de administración exclusivamente tópicas, con respecto a esto Brennan y Cols. [20] expresan que existe mucha incertidumbre acerca de si los antibióticos tópicos mejoran o no la resolución de la secreción del oído en los pacientes con otitis media supurativa crónica. Pensamos que desde el punto de vista clínico, el abordaje terapéutico de las patologías ambulatorias del oído, no solo debe enfocarse al tratamiento sintomatológico sino que debe orientarse a obtener la curación completa del proceso causal, ya que como se observó en nuestro estudio la antibioterapia prolongada no es del todo eficaz para evitar las frecuentes recidivas y complicaciones, por lo que expresamos que el uso significativo de antibióticos orales, más allá de la terapia tópica, podría tener implicaciones en términos de costo, aparición de resistencia microbiana, riesgo de efectos secundarios y mayor probabilidad de incumplimiento terapéutico por parte del paciente, con respecto a esto Migirov y cols.…”

Section: Materials Y Métodounclassified

Aspectos clinicoepidemiológicos de las patologías ambulatorias del oído frecuentes en adultos

Gea¹

2020

ORL

View full text Add to dashboard Cite

Conflicto de intereses: Los autores declaran no tener conflictos de intereses Imágenes: Los autores declaran haber obtenido las imágenes con el permiso de los pacientes Política de derechos y autoarchivo: se permite el autoarchivo de la versión post-print (SHERPA/RoMEO) Licencia CC BY-NC-ND. Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional Universidad de Salamanca. Su comercialización está sujeta al permiso del editor Ediciones Universidad de Salamanca / CC BY-NC-ND [2] Rev. ORL, 20xx, x, x, pp. xx-xx cional, así mismo se identificó que el uso significativo de antibióticos orales, más allá de la terapia tópica, no es del todo eficaz para evitar recidivas y complicaciones. PALABRAS CLAVE Epidemiologia y clínica de las patologías ambulatorias del oído; Uso de antihistamínicos; Terapia prologada con antibióticos orales y tópicos, OMC y otomicosis en adultos SUMMARY Introduction and objective: Otorhinolaryngology pathology has a high incidence in acute and chronic conditions in the ENT outpatient clinic, despite this; there are no accurate, reliable and standardized statistical data on the epidemiological profile of ambulatory otology pathologies in our setting. The objective of this study was to describe the clinical, epidemiological, treatment and follow-up characteristics of the three outpatient otological pathologies frequently diagnosed in the otorhinolaryngological consultation in our region. Method: A retrospective observational study was carried out in 312 patients with otological pathologies; the variables studied were processed through the IBM-SPSS® statistical program, applying a descriptive statistical technique. Results: The three most frequent outpatient diagnoses were: chronic otitis media in 60.6%, predominated in women with 44%; 12.8% presbycusis, in which there was no sex distinction and 12.17% otomycosis affecting women in 65.7%. They had a higher prevalence in people older than 51 years, from the urban area, without any professional training, manifesting as hearing loss, otorrhea, otalgia and otic pruritus, referred in isolation or in combination. It was evident that otomicroscopy, impedanciometry and liminal tone audiometry were the main otological techniques performed for the diagnosis. Pharmacological treatment in infectious processes was oral and otic ciprofloxacin, oral fluconazole associated clotrimazole or clioquinol otic, the prescription of loratadine was observed in 91.5% of patients with OMC, 40% in patients with presbycusis and 73.6% in patients with otomycosis. The main clinical complications were found in patients with OMC after a second evaluation, which were facial paralysis 2.1% and acquired cholesteatoma associated with chronic otomastoiditis in 0.96%. Discussion: The prevalence and involvement in terms of sex due to OMC, presbycusis and otomycosis disagrees with that obtained in other investigations although its prevalence with respect to age is similar to that reported by other researchers. Complementary diagnostic and treatment techniques are align...

show abstract

Topical antibiotics for chronic suppurative otitis media

Abstract: This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of topical antibiotics for people with chronic suppurative otitis media (CSOM).

Cited by 33 publications

References 128 publications

Anti-biofilm multi drug-loaded 3D printed hearing aids

Anti-biofilm multi drug-loaded 3D printed hearing aids

Tympanostomy Tube Controversies and Issues: State-of-the-Art Review

Aspectos clinicoepidemiológicos de las patologías ambulatorias del oído frecuentes en adultos

Contact Info

Product

Resources

About