Topical anti-inflammatory effect of acetone rhizome/root extract of Potentilla malýana Borbas

Pilipović, S; Bosnić, T.; Redžić, Sulejman; Mijanović, Mirjana

doi:10.1055/s-2007-986801

Cited by 3 publications

(2 citation statements)

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“…Acetone and ethanol extracts of the tested plant species Potentilla have significantly reduced inflammation in time for 30-50% in relation to control ear. Similarly, the acetone extract of the rhizome and root of Potentilla malýana BORBÁS has been evaluated for anti-inflammatory potential using the mouse ear edema model (Pilipović et al, 2005;Pilipović et al, 2007).…”

Section: In Vivo Experimentsmentioning

confidence: 99%

Potentilla—A review of its phytochemical and pharmacological profile

Tomczyk

Latté²

2009

Journal of Ethnopharmacology

241

213

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Section: In Vivo Experimentsmentioning

confidence: 99%

Potentilla—A review of its phytochemical and pharmacological profile

Tomczyk

Latté²

2009

Journal of Ethnopharmacology

241

213

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“…As agrimoniin has a very potent astringent capacity [20] this may also be a reason for the prominent anti-inflammatory effect of PE4 in our experiments. Besides Pilipovic and colleagues demonstrated an anti-inflammatory effect of Potentilla malýana acetone and ethanol extracts in a mouse ear edema model [21]. Furthermore purified agrimoniin was described to be an exceptional good inhibitor of oxidative stress-induced histamine release [4].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Agrimoniin-Enriched Fractions of Potentilla erecta

et al. 2016

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Potentilla erecta (PE) is a small herbaceous plant with four yellow petals belonging to the Rosaceae family. The rhizome of PE has traditionally been used as an antidiarrheal, hemostatic and antihemorrhoidal remedy. PE contains up to 20% tannins and 5% ellagitannins, mainly agrimoniin. Agrimoniin is a hydrolyzable tannin that is a potent radical scavenger. In this study we tested the anti-inflammatory effect of four PE fractions with increasing amounts of agrimoniin obtained by Sephadex column separation. First, we analyzed in HaCaT keratinocytes the expression of cyclooxygenase-2 (COX-2) induced by ultraviolet-B (UVB) irradiation. As COX-2 catalyzes the metabolism of arachidonic acid to prostanoids such as PGE 2 , we also measured the PGE 2 concentration in cell culture supernatants. PE inhibited UVB-induced COX-2 expression in HaCaT cells and dose-dependently reduced PGE 2 . The PE fraction with the highest agrimoniin amount (PE4) was the most effective in this experiment, whereas fraction PE1 containing mainly sugars had no effect. PE4 also dose dependently inhibited the phosphorylation of the epidermal growth factor receptor (EGFR) which plays a crucial role in UVB-mediated COX-2 upregulation. A placebo-controlled UV-erythema study with increasing concentrations of PE4 demonstrated a dose dependent inhibition of UVB-induced inflammation in vivo. Similarly, PE4 significantly reduced UVB-induced PGE 2 production in suction blister fluid in vivo. In summary, PE fractions with a high agrimoniin content display anti-inflammatory effects in vitro and in vivo in models of UVB-induced inflammation.

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Biological activities and chemical components of Potentilla kleiniana Wight & Arn

Xuan

Hong

Lee

et al. 2019

Natural Product Research

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In this study, we investigated the antimicrobial, antioxidant, and cytoprotective activities of ethanol extract and the ethyl acetate (EtOAc) fraction of P. kleinianaWight & Arn.. The EtOAc fraction exhibited antimicrobial effects against most of the microorganisms that were tested, including Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa, and, Escherichia coli, but not Aspergillus niger. In addition to its excellent antioxidant activity, the EtOAc fraction attenuated the UVB-induced cell death via upregulation of caspase-3 expression in human keratinocytes. The HPLC/ESI-MS/MS analysis allowed identification of the components in the EtOAc fraction. Overall, our results suggest that P. kleiniana is a valuable source of bioactive compounds for the development of pharmaceuticals and cosmetics.

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Topical anti-inflammatory effect of acetone rhizome/root extract of Potentilla malýana Borbas

Cited by 3 publications

References 0 publications

Potentilla—A review of its phytochemical and pharmacological profile

Potentilla—A review of its phytochemical and pharmacological profile

Anti-Inflammatory Effects of Agrimoniin-Enriched Fractions of Potentilla erecta

Biological activities and chemical components of Potentilla kleiniana Wight & Arn

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