Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid

Baričević, Dea; Sosa, Silvio; Loggia, R. Della; Tubaro, Aurelia; Simonovska, Breda; Krasna, A.; Zupančič, A.

doi:10.1016/s0378-8741(00)00396-2

Cited by 352 publications

(218 citation statements)

References 12 publications

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“…This compound is also known to have antimicrobial (Alma et al, 2003;Lourens et al, 2004), antioxidant (Lourens et al, 2004, Singh et al, 2006, anticarcinogenic (Kubo et al, 1996) and skin-penetration-enhancing properties (Cornwell & Barry, 1994). Essential oils containing this compound as a major component showed marked anti-inflammatory activity against carrageenan-and prostaglandin E 1 -induced edema in rats as well as anti-arthritic activity (Martin et al, 1993;Baricevic et al, 2001;Agarwal & Rangari, 2003). Oral administration of β-caryophyllene to rats significantly inhibited gastric mucosal injuries induced by acidic ethanol (Tamble et al, 1996) and DSS-induced experimental colitis, being useful in the prevention and treatment of colitis (Cho et al, 2007).…”

Section: Myrciaria Tenella and Calycorectes Sellowianusmentioning

confidence: 99%

Anti-inflammatory activity of essential oil from leaves ofMyrciaria tenellaandCalycorectes sellowianus

Apel

Lima

Sobral

et al. 2010

Pharmaceutical Biology

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Section: Myrciaria Tenella and Calycorectes Sellowianusmentioning

confidence: 99%

Anti-inflammatory activity of essential oil from leaves ofMyrciaria tenellaandCalycorectes sellowianus

Apel

Lima

Sobral

et al. 2010

Pharmaceutical Biology

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“…UA is well known to possess various biological activities, including anti-inflammatory (5,6), anticancer (7,8), hypoglycemic (9), antioxidant (10)(11)(12) and immunomodulatory activities (13). Previously, UA was reported to be involved in colitis in a number of publications (4,14,15).…”

Section: Introductionmentioning

confidence: 99%

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice

Liu

Piao

Guo

et al. 2016

Molecular Medicine Reports

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Abstract. Ursolic acid (UA) has been reported to have a protective effect in colitis. However, the underlying mechanisms remain to be elucidated. In the present study, experimental ulcerative colitis was induced in male BALB/c mice by the administration of 5% dextran sulfate sodium (DSS) for 7 days, followed by treatment with UA for another 7 days. Hematoxylin & eosin staining was performed to evaluate colon tissue damage, and enzyme assays were used to measure malondialdehyde (MDA) content and superoxide dismutase (SOD) activity in colon homogenate. In addition, serum levels of interleukin (IL)-1β and tumor necrosis factor (TNF)-α were measured using an ELISA, and the level of nuclear factor (NF)-κB p65 in the colonic tissues was assessed by western blotting. The 7-day DSS administration induced marked colon damage, increased the serum levels of IL-1β and TNF-α, increased MDA content and decreased SOD activity in the colon homogenate. These changes were significantly improved by treatment with UA. UA also reduced the DSS-stimulated high nuclear level of NF-κB p65 in the colon tissues. These results demonstrate a protective role of UA in ulcerative colitis, and suggest that anti-inflammatory and antioxidant activities are involved in the underlying mechanisms.

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“…The genus Salvia (sage) encompasses about 900 species of plants belonging to the mint family Lamiaceae (Labiatae; Gali-Muhtasib et al 2000). Different types of extracts of Salvia officinalis has possessed antioxidant, anti-inflammatory, hypoglycemic and anti-mutagenic bioactivities (Wang et al 1998, Baricevic et al 2001, Alarcon-Aquilar et al 2002. Based on our previous results (Szabóová 2008b), in this study combined use of Ent 4231 and sage plant extract in rabbits was tested with the aim to detect their antimicrobial activity, immunological and biochemical blood parameters, the values of lactic acid and volatile fatty acids in the content of the caecum, reduction of Eimeria sp.…”

Section: Introductionmentioning

confidence: 99%

Effect of combined administration of enterocin 4231 and sage in rabbits

Szabóová¹,

Lauková²,

Chrastinová³

et al. 2011

Polish Journal of Veterinary Sciences

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Enterocin (Ent) 4231, produced by non-rabbit origin strain Enterococcus faecium CCM 4231 was used in combination with sage plant extract in rabbits with the aim to check their antimicrobial activity against microbiota, their effect on immunological, biochemical blood parameters, values of volatile fatty acids in caecum, Eimeria sp. oocysts occurrence and selected parameters of rabbits meat. The animals were divided into three experimental groups (EG1-Ent 4231; EG2-sage; EG3-Ent 4231 with sage) and control group (CG); 24 rabbits in each. Natural substances (NS) were administered for 21 days. The experiment lasted for 42 days. The reduction of microbiota in faeces was observed in EG3 at day 21 by a decrease in the numer of coagulase-positive staphylococci (P<0.01) in comparison with that determined in CG. The bacterial counts in the caecum were lower than those found in faeces. A decrease in the numer of Pseudomonas-like sp. in caeca of the experimental groups was observed at days 21 and 42 (difference in range 0.40-1.87 log cycles) comparing with that determined in CG. At day 21, a significant increase in phagocytic activity (PA, P<0.001) was found in blood of rabbits from EG2 comparing with that observed in CG. At day 42, a significant increase in PA (P<0.001) was determined in all experimental groups in comparison with CG. At day 21, in caecal content of EG3 significantly higher values of lactic acid were observed (P<0.05) in comparison with those found in CG. The reduction of Eimeria sp. oocysts was demonstrated after application of each of NS. Addition of NS did not influence biochemical parameters, meat quality of the animals and does not influence negatively the health status of rabbits.

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Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid

Cited by 352 publications

References 12 publications

Anti-inflammatory activity of essential oil from leaves ofMyrciaria tenellaandCalycorectes sellowianus

Anti-inflammatory activity of essential oil from leaves ofMyrciaria tenellaandCalycorectes sellowianus

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice

Effect of combined administration of enterocin 4231 and sage in rabbits

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