Topical and bioavailability of benzoyl peroxide

Sahut, A.; Aiache, S.; Andermann, G.; Burlet, G.; Aiache, J M

doi:10.1111/j.1467-2494.1985.tb00397.x

Cited by 3 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When applied to the skin, BPO is converted to benzoic acid and is absorbed, distributed, metabolized and excreted in the urine as such . There is no apparent accumulation of benzoic acid after repeated dosing . The transepidermal delivery of BPO is dependent on concentration and no systemic toxicity is expected due to rapid renal clearance of benzoic acid …”

Section: Introductionmentioning

confidence: 99%

“…17 There is no apparent accumulation of benzoic acid after repeated dosing. 18 The transepidermal delivery of BPO is dependent on concentration and no systemic toxicity is expected due to rapid renal clearance of benzoic acid. 19 Although a well-established topical acne treatment, the use of BPO gel has not been approved in Japan due to the controversial perception that BPO is a tumor promoter for skin carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is benzoyl peroxide 3% topical gel effective and safe in the treatment of acne vulgaris in Japanese patients? A multicenter, randomized, double‐blind, vehicle‐controlled, parallel‐group study

Kawashima

Hashimoto

Saenz

et al. 2014

The Journal of Dermatology

View full text Add to dashboard Cite

Benzoyl peroxide (BPO) as an anti-acne medication is not yet approved in Japan. This study evaluated the efficacy and safety of a once-daily topical application of BPO 3% gel versus an inert vehicle gel in Japanese acne patients. Three hundred and sixty patients were randomized to receive BPO 3% or vehicle for 12 weeks. The primary efficacy end-point was absolute change in number of total lesions (TL) from baseline to week 12 to demonstrate the superiority of BPO 3% versus vehicle. Secondary efficacy end-points were absolute and percent change in TL, inflammatory lesions (IL), non-inflammatory lesions (non-IL) and Investigator's Static Global Assessment (ISGA). Change in TL counts from baseline to week 12 for BPO 3% was superior to vehicle (difference, À21.0; P < 0.001). Absolute and percent reductions in TL, IL and non-IL counts were greater for BPO 3% at all study visits. The proportion of patients with improvement in ISGA scores was significantly higher with BPO 3% than with vehicle from week 2. All adverse events were mild or moderate. Adverse drug-related reactions were higher for BPO 3% (30%) than with vehicle (5%). Local tolerability scores of grade 1 or more (slight to moderate) were more frequent with BPO 3% than vehicle with the most significant differences observed in dryness (56% vs 27% at week 1-4), peeling (19% vs 9% at week 1-2) and burning/stinging (58% vs 15% at week 1-12). These results indicate that BPO 3% is effective while maintaining a favorable safety and tolerability profile in Japanese acne patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is benzoyl peroxide 3% topical gel effective and safe in the treatment of acne vulgaris in Japanese patients? A multicenter, randomized, double‐blind, vehicle‐controlled, parallel‐group study

Kawashima

Hashimoto

Saenz

et al. 2014

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

Topical α-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin

Weber

Thiele

Han

et al. 2003

Free Radical Biology and Medicine

View full text Add to dashboard Cite

Distribution and dissociation of benzoyl peroxide in cutaneous tissue after application on skin in the hairless rat

Wépierre¹,

Corroller²,

Didry

1986

Intern J of Cosmetic Sci

View full text Add to dashboard Cite

Synopsis The distribution and dissociation of 14C-benzoyl-peroxide were studied in the skin of hairless rats after the application of a 10% gel during 3, 8 and 24 h. The distribution was appraised in the stripped horny layer and in the epidermis, and the dermis cut in slices parallel to the cutaneous surface. The conversion of benzoyl peroxide (b.p.) to benzoic acid (b.a.) was investigated from extracts of these different cutaneous layers by thin layer chromatography (TLC). The greatest amount of penetrating b.p. (9 to 14% of the applied dose) was found in the horny layer, which forms a reservoir and where biotransformations were reduced. Small quantities of b.p. diffused toward the epidermis down to the deeper dermis, where b.a. represented 74% of the radioactivity. Distribution gradients of the radioactivity and conversion rates to b.a. were stable between 3 and 24 h of application in all parts of the skin. This result showed that diffusion of b.p. from the vehicle was in balance with the dissociation processes and the blood resorption as b.a., throughout the experiment.

show abstract

Topical and bioavailability of benzoyl peroxide

Cited by 3 publications

References 4 publications

Is benzoyl peroxide 3% topical gel effective and safe in the treatment of acne vulgaris in Japanese patients? A multicenter, randomized, double‐blind, vehicle‐controlled, parallel‐group study

Is benzoyl peroxide 3% topical gel effective and safe in the treatment of acne vulgaris in Japanese patients? A multicenter, randomized, double‐blind, vehicle‐controlled, parallel‐group study

Topical α-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin

Distribution and dissociation of benzoyl peroxide in cutaneous tissue after application on skin in the hairless rat

Contact Info

Product

Resources

About