Topical amphotericin B in ultradeformable liposomes: Formulation, skin penetration study, antifungal and antileishmanial activity in vitro

Perez, Ana Paula; Altube, María Julia; Schilrreff, Priscila; Apezteguia, Gustavo Alberto; Celes, Fabiana S.; Zacchino, Susana; Romero, Eder Lilia; Morilla, María José

doi:10.1016/j.colsurfb.2015.12.003

Cited by 127 publications

(69 citation statements)

References 30 publications

(31 reference statements)

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“…The readjustment of edge activators in UDLs was speculated to be the main reason why UDLs pass through the pores smaller than their own diameter without being disassembled. 42,43 Optimal PC to edge activator ratios were selected as 8:2 and 7:3 (w/w) on the basis of particle size, PDI, entrapment efficiency, and deformability index from our preliminary studies. In the preliminary studies, MTX-UDLs with PC to edge activator ratio of 9:1 and 6:4 were also prepared and evaluated.…”

Section: Results and Discussion Preparation Of Mtx-udlsmentioning

confidence: 99%

Improved skin permeation of methotrexate via nanosized ultradeformable liposomes

Zeb¹,

Qureshi²,

Kim³

et al. 2016

IJN

126

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The aim of this study is to investigate methotrexate-entrapped ultradeformable liposomes (MTX-UDLs) for potential transdermal application. MTX-UDLs were prepared by extrusion method with phosphatidylcholine as a bilayer matrix and sodium cholate or Tween 80 as an edge activator. The physicochemical properties of MTX-UDLs were determined in terms of particle size, polydispersity index, zeta potential, and entrapment efficiency. The deformability of MTX-UDLs was compared with that of methotrexate-entrapped conventional liposomes (MTX-CLs) using a steel pressure filter device. The skin permeation of MTX-UDLs was investigated using Franz diffusion cell, and the skin penetration depth of rhodamine 6G-entrapped UDLs was determined by confocal laser scanning microscopy. MTX-UDLs showed a narrow size distribution, with the particle size of ~100 nm. The deformability of MTX-UDLs was two to five times greater than that of MTX-CLs. The skin permeation of MTX-UDLs was significantly improved compared with MTX-CLs and free MTX solution. The optimized UDLs (phosphatidylcholine: Tween 80 =7:3, w/w) showed a higher fluorescence intensity than conventional liposomes at every increment of skin depth. Thus, the optimized UDLs could be promising nanocarriers for systemic delivery of MTX across skin.

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Section: Results and Discussion Preparation Of Mtx-udlsmentioning

confidence: 99%

Improved skin permeation of methotrexate via nanosized ultradeformable liposomes

Zeb¹,

Qureshi²,

Kim³

et al. 2016

IJN

126

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“…50 However, this finding was contradictory to recently published investigations, where Tween 80 (high HLB) was claimed to cause greater deformability and permeation (72.41%±3.2%) of the ELs loaded with AmB. 32 Similarly, itraconazole (IT) -due to high lipophilicity (log P.5.5), poor aqueous solubility (1 µg/mL), and relatively high molecular weight (~705 Da) -received attention from researchers for TD using ELs in the treatment of superficial or cutaneous fungal infections. 4,36 An IT-hydroxylpropyl-β-cyclodextrin complex loaded EL enhanced permeation across the skin and retained antifungal activity as compared to the plain DS.…”

mentioning

confidence: 87%

“…32 In addition to these distinct advantages, the carrier is of great interest to formulation scientists and research groups for the successful delivery of drugs owing to obvious advantages inherent in the carrier and ease of therapy termination.…”

Section: Td Of Various Drugs Topical Elastic Liposome: Advantages Andmentioning

confidence: 99%

“…46 Candida spp.-mediated infections caused in immunocompromised patients and those with burn wounds have increased to cause a 14%-70% rise in mortality. 32,47,48 Metronidazole, miconazole, itraconazole, and amphotericin B (AmB) are commonly used broad-spectrum drugs in local and systemic infections. 46 Poor water solubility and limited permeation across biological membranes have limited its clinical efficacy.…”

mentioning

confidence: 99%

“…51 Recently, poorly soluble and low-permeable AmB was investigated to treat cutaneous fungal infections and leishmaniasis. 32 Commercially available salt (parenteral) is responsible for serious nephrotoxicity and several side effects. 52 Moreover, the effect of EL components on several parameters was studied (eg, deformability, vesicle size, % EE, in vitro drug release, and ex vivo and in vivo performance).…”

mentioning

confidence: 99%

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Elastic liposomes as novel carriers: recent advances in drug delivery

Hussain¹,

Singh²,

Sharma

et al. 2017

IJN

138

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Elastic liposomes (EL) are some of the most versatile deformable vesicular carriers that comprise physiologically biocompatible lipids and surfactants for the delivery of numerous challenging molecules and have marked advantages over other colloidal systems. They have been investigated for a wide range of applications in pharmaceutical technology through topical, transdermal, nasal, and oral routes for efficient and effective drug delivery. Increased drug encapsulation efficiency, enhanced drug permeation and penetration into or across the skin, and ultradeformability have led to widespread interest in ELs to modulate drug release, permeation, and drug action more efficiently than conventional drug-release vehicles. This review provides insights into the versatile role that ELs play in the delivery of numerous drugs and biomolecules by improving drug release, permeation, and penetration across the skin as well as stability. Furthermore, it provides future directions that should ensure the widespread use of ELs across all medical fields.

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Leishmaniasis

Imani¹,

Dehghan²

2020

Nanobiotechnology in Diagnosis, Drug Delivery, and Treatment

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Topical amphotericin B in ultradeformable liposomes: Formulation, skin penetration study, antifungal and antileishmanial activity in vitro

Cited by 127 publications

References 30 publications

Improved skin permeation of methotrexate via nanosized ultradeformable liposomes

Improved skin permeation of methotrexate via nanosized ultradeformable liposomes

Elastic liposomes as novel carriers: recent advances in drug delivery

Leishmaniasis

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