Topic usage of kaolin-impregnated gauze as a hemostatic in tonsillectomy

Chávez-Delgado, Maria Estela; Kishi-Sutto, Celina Verónica; la-Riva, Xellic Nallely Albores de; Rosales-Cortés, Manuel; Gamboa-Sánchez, Paulino

doi:10.1016/j.jss.2014.05.040

Cited by 16 publications

(9 citation statements)

References 28 publications

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“…In 2008, kaolin began replacing zeolite products (QuikClot ® , QuikClot™, ACS™, ACS™+) in combat medical dressings and is marketed widely as QuikClot ® Combat Gauze (QCG, Z-Medica Corporation, CT). QCG has been used in successfully stopping the bleeding from serious wounds of liver, mesentery, and femoral vessels within a minute in large animal testing [10,15,16,17,18], achieving hemostasis with a complete efficiency of 84.8% in patients [19]. It is reported that kaolin promotes clotting by activating Factor XII, in which it initiates the intrinsic clotting cascade via activating Factor XI and ends with the formation of a fibrin clot.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Hemostatic Potential of Two Kaolins from Southern China

Gan

Hu²,

Meng

et al. 2019

Molecules

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The physicochemical properties and potential hemostatic application of Wenchang kaolin and Maoming kaolin were inspected and evaluated. Chemical composition analysis, Fourier transform infrared (FTIR) spectroscopy, surface area determination, X-ray diffraction, particle size, scanning electron microscopy (SEM) observations, and zeta potential analysis were performed to quantify the physical and chemical properties of the two kaolins. The results showed that both kaolins have typical FTIR bands of kaolinite with a weight fraction for kaolinite over 90 wt%. Larger conglobate aggregates of Maoming kaolin demonstrated wider particle size distributions with two peaks at 3.17 and 35.57 μm, while the book-like Wenchang kaolin had narrow particle size distribution, with a frequent size of 5.64 μm. Furthermore, thrombelastography, the whole blood clotting tests (WBCT), plasma recalcification time (PRT) measurement, and MTT assay were performed to measure the clotting activities and biocompatibility of the two kaolins. The results showed that both kaolins could promote blood coagulation with good cytocompatibility, while Wenchang kaolin had a better procoagulant activity than Maoming kaolin. These findings demonstrated Wenchang kaolin to be a more suitable local source material for application as a hemostatic agent.

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Section: Introductionmentioning

confidence: 99%

Characterization and Hemostatic Potential of Two Kaolins from Southern China

Gan

Hu²,

Meng

et al. 2019

Molecules

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“…Kaolinite has been used as an antimicrobial agent and blood clotting agent. When applied to the wound site as dressing, Kaolinite initiates the clotting process through transforming and activating the coagulation and prevents bleeding [26,27].…”

Section: Medical Applicationsmentioning

confidence: 99%

Kaolinite-Chitosan based Nano-Composites and Applications

Saibaba

2022

Advanced Applications of Micro and Nano Clay

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Chitosan is a naturally available biopolymer, having numerous applications due to its unique physico-chemical properties. Kaolinite is one of the abundantly available clay, combining these two materials imparts excellent properties suitable for various applications. Although various chitosan-based composites are developed greater attention is focused on kaolinite- chitosan composites in recent years. This chapter discusses developments in various kaolinite- chitosan nanocomposites and their applications particularly in medical, pharmaceutical, wastewater treatment and food and packaging industries. First, discussion on chitosan and kaolinite is given, then kaolinite- chitosan nanocomposite fabrication, advances, development and followed by various applications of chitosan-kaolinite nanocomposites. Finally concluding remarks are presented to summarize latest developments in this area. Challenges and future perspectives are also given in conclusions to guide the research directions.

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“…Quikclot Combat gauze facilitates rapid coagulation of the bleeding site and is a widely used hemostatic dressing among US Army and civilians for rapid hemostasis 13 . Several hemostatic dressings with kaolin and a combination of other chemicals are available in the market [14][15][16][17] . However, the presence of only the fine clay particles sometimes poses a risk of thrombosis which may arise due to the particle detachment from gauze during use.…”

Section: Introductionmentioning

confidence: 99%

In-vitro Analysis of Hemostatic Cotton Khadi Dressing with Kaolin/Chitosan-based Composition and Its Application as Prospective Wound Dressing

Raval¹,

Patel²,

Pancholi³

2022

Preprint

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The current investigation illustrates the formulation of Kaolin/Chitosan-based composition by using a simple mechanochemical method that can produce a stabilized hemostatic composition. Chitosan is stabilized in sodium hydroxide solution with which kaolin solution is mixed under controlled conditions. When the formulated hemostatic composition was impregnated on cotton khadi dressing it showed drastically improved hemostatic efficiency as compared to standard cotton gauze. The tightly woven cotton khadi fabric has a larger surface area as compared to standard cotton gauze and so it retains more hemostatic composition. The hemostatic properties of the composition are characterized using various in-vitro testing techniques like bleeding time analysis, clotting time analysis, absorption strength study, and several other parameters. Investigation of the freshly drawn blood samples from humans was used for experimenting in order to obtain highly accurate results. The results demonstrate that Kaolin/Chitosan composite impregnated cotton khadi dressing can noticeably enhance the hemostasis other than being biocompatible as demonstrated through an animal model and fresh blood study.

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Topic usage of kaolin-impregnated gauze as a hemostatic in tonsillectomy

Cited by 16 publications

References 28 publications

Characterization and Hemostatic Potential of Two Kaolins from Southern China

Characterization and Hemostatic Potential of Two Kaolins from Southern China

Kaolinite-Chitosan based Nano-Composites and Applications

In-vitro Analysis of Hemostatic Cotton Khadi Dressing with Kaolin/Chitosan-based Composition and Its Application as Prospective Wound Dressing

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