Tophi as the Initial Manifestation of Gout

Wernick, Richard; Winkler, Craig; Campbell, Stephen

doi:10.1001/archinte.1992.00400160155032

Cited by 75 publications

(6 citation statements)

References 20 publications

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“…The development of tophi in patients with gout is related to the duration of the disease and typically is associated with untreated hyperuricaemia, and manifest in only 3–21% of patients with gout (18,19). Although gout has an overall male predominance, late‐onset gout and the development of tophaceous gout are more frequent in females, which maybe related to the loss of the protective effects of oestrogen after menopause (20,21). Although uncommon, tophaceous gout may present without a preceding history of painful arthritis (20).…”

Section: Clinical Details Of the Three Patients With Ulceration Over mentioning

confidence: 99%

“…Although gout has an overall male predominance, late‐onset gout and the development of tophaceous gout are more frequent in females, which maybe related to the loss of the protective effects of oestrogen after menopause (20,21). Although uncommon, tophaceous gout may present without a preceding history of painful arthritis (20). The formation of tophi is associated with a chronic inflammatory cell infiltrate, consisting of macrophages that surround the often necrotic monosodium crystal‐laden core (22).…”

Section: Clinical Details Of the Three Patients With Ulceration Over mentioning

confidence: 99%

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Ulcerated tophaceous gout

Patel

Davies

Price

et al. 2010

International Wound Journal

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Section: Clinical Details Of the Three Patients With Ulceration Over mentioning

confidence: 99%

Section: Clinical Details Of the Three Patients With Ulceration Over mentioning

confidence: 99%

Ulcerated tophaceous gout

Patel

Davies

Price

et al. 2010

International Wound Journal

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“…It is characterised by the presence of tophus, an uratic tissular deposit whose development is correlated with the level and the duration of hyperuricaemia 4. Those tophi affect not only the hypoderma, the tendons and their sheaths but also the articular and para-articular structures and the bone.…”

Section: Discussionmentioning

confidence: 99%

Infection of a tophaceous nodule of the wirst and hand

Bouaziz¹,

Rekik

Guidara

et al. 2018

BMJ Case Reports

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Tophaceous gout occurs years after recurrent attacks of acute inflammatory arthritis. The urate deposits are incriminated in the inflammatory process; however, their infection is exceptional. We report the observation of an infected gouty tophus of the pinky and the wrist of a 40-year-old man, presented as an excruciating inflammatory pain with buff-yellow swelling of the fifth right finger and wrist in a febrile context. As a matter of fact, the evolution was favourable after surgical excision and antibiotic therapy. The infection of a tophus is an exceptional complication of the gout. In daily practice, this diagnosis is really a difficult challenge for the clinician. The systematic bacteriological examination of the tophi with cutaneous fistulation is necessary to introduce prematurely an adapted treatment.

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“…While an association with elevated serum uric acid levels is evident, our current knowledge of the pathogenesis is incomplete [1,2]. Pre-existing tissue damage induced by venous stasis and micro-trauma may play roles.…”

Section: Discussionmentioning

confidence: 99%

Disseminated gouty panniculitis: an unusual presentation of extensive cutaneous tophi

Pattanaprichakul

Bunyaratavej

McLain

et al. 2014

Dermatol Pract Concept

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Gouty panniculitis is a rare cutaneous illness characterized by the deposition of subcutaneous mono-sodium urate crystals with lobular panniculitis. Only a small number of cases with gouty panniculitis have been reported in the literature with unclear pathogenesis. In this article, we present a case of disseminated gouty panniculitis in the patient who had never been diagnosed of gout but revealed significant hyperuricemia at the time of diagnosis.

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Tophi as the Initial Manifestation of Gout

Cited by 75 publications

References 20 publications

Ulcerated tophaceous gout

Ulcerated tophaceous gout

Infection of a tophaceous nodule of the wirst and hand

Disseminated gouty panniculitis: an unusual presentation of extensive cutaneous tophi

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